TUGAS STRUKTUR PERKEMBANGAN HEWAN

HUSRI MELI 1210421012

UNIVERSITAS ANDALAS 2013

PROSES PEMBENTUKAN MELANOSIT

Melanosi !e"#$a%an sel %&#s#s 'an( e")a$a $a)a e$i)e"!is* )i+#!$ai )i ,a-a& a a# )i an a"a sel.sel s "a #! ,asalis )an $a)a /oli%el "a!,# 0 Asal e!,"iolo(i )a"i !elanosi ,e"asal )a"i sel %"is a ne#"al0 Melanosi !e!ili%i ,en #% ,a)an sel ,#la e!$a ,e"!#lan'a 1a,an(.1a,an( $an+an( 'an( i"e(#le" )ala! e$i)e"!is0 2a,an(.1a,an( ini ,e"a)a )i an a"a sel.sel s "a #! ,asalis )an s "a #! s$inos#!0

Ga!,a" )ia as a)ala& Dia("a! Melanosi 0 3#l#"an !elanosi !el#as &in((a %e an a"a %e"a onosi 0 G"an#l !elanin )isin esis )i )ala! !elanosi * %e!#)ian ,e"!i("asi %e )ala! %e"a inosi 0

Den(an !i%"os%o$ ele% "on e"li&a sel 'an( ,e"-a"na $#1a * ,e"isi%an ,an'a% !i o%on)"ia %e1il* %o!$le%s (ol(i san(a ,e"%e!,an(*sis e"na $en)e% $a)a "e i1#l#! en)o$las!a 'an( %asa"0 Mes%i$#n !elanosi i)a% )ile%a %an )en(an %e"a inosi 'an( ,e")e%a an )en(ann'a ole& )es!oso!* !elanosi ini

)ile a%%an %e la!ina ,asalis )en(an &e!i)es!oso!0

Ga!,a" )ia as a)ala& (a!,a"an

!i%"os%o$ ele1 "on %#li !an#sia0 Te")i"i )a"i

!elanosi )an %e"a inosi 0 Te"li&a ("an#l !elanin 'an( san(a ,an'a% $a)a %e"a inosi )i se,ela& %anan )i,an)in(%an 'an( e")a$a )i !elanosi sen)i"i0 Ga!,a"an !a e"ial $# i& )i ,a(ian ,a-a& a)ala& %ola(en )e"!is0

Pembentukan Pigmen Melanin Melanin )i,en #% ole& !elanosi )en(an en4i! i"osinase !e!ain%an $e"anan $en in( )ala! $"oses $e!,en #%ann'a0 Se,a(ai a%i,a )a"i %e"+a enzim tironase* tiroksin )i#,a& !en+a)i 3,4 dihidroksiferil alanin (DOPA) )an %e!#)ian !en+a)i dopaquinone* 'an( %e!#)ian )i%on5e"si* se ela& !elal#i ,e,e"a$a a&a$ "ans/o"!asi !en+a)i melanin0 En4i! i"osinase )i,en #% )ala! "i,oso!* )i "ans/e" )ala! l#!e" "e i%#l#! en)o$las!a %asa"* !elanosi )ia%#!#lasi )ala! 5esi%el 'an( )i,en #% ole& %o!$le%s (ol(i0 Adapun 4 tahapan yang dapat dibedakan pada pembentukan granul melanin yang matang adalah !ahap pertama Se,#a& 5esi%el )i%elilin(i ole& !e!,"an )an !en#n+#%%an a-al $"oses )a"i a% i5i as en4i! i"osinase )an $e!,en #%an s#,s ansi ("an#l &al#s6 $a)a ,a(ian $e"i/e"n'a0 Un aian.#n aian $a)a ele% "on !e!ili%i s#a # s#s#nan !ole%#l i"osinase 'an( "a$i $a)a se,#a& !a "i% $"o ein0

!ahap ke dua Vesi%el 7!elanoso!8 ,e",en #% o5al )an !e!$e"li&a %an $a)a ,a(ian )ala! /ila!en./ila!en )en(an +a"a% se%i a" 10 n! a a# (a"is lin an( )en(an +a"a% sa!a0 Melanin )isi!$an )ala! !a "i%s $"o ein0 !ahap ke tiga Penin(%a an $e!,en #%an !elanin !e!,#a s "#% #" &al#s a(a% s#li e"li&a 0 !ahap ke empat G"an#l !elanin !a an( )a$a e"li&a )en(an !i%"os%o$ 1a&a'a )an !elanin se1a"a se!$#"na !en(isi 5esi%el0 U "as "#% #" i)a% a)a 'an( e"li&a 0 G"an#l 'an( !a an( ,e",en #% eli$s* )en(an $an+an( 1 9! )an )ia!e e" 0*: 9!00

Ga!a"

)ia as

a)ala&

Dia("a!

Melanosi *

il#s "asi

(a!,a"an

# a!a

!elano(enesis0 Ti"osinase )i sin esis )ala! "e i%#l#! en)o$las!a 'an( %asa" )an )ia%#!#lasi%an )ala! 5esi%el %o!$le%s Gol(i0 Vesi%el 'an( ,e,as se%a"an( )ina!a%an !elanoso!0 Sin esis !elanin )i!#lai $a)a !elanoso! a&a$ II* )i !ana !elanin )ia%#!#lasi%an )an !e!,en #% !elanoso! a&a$ III0 Te"a%&i"s "#% #" ini &ilan( )en(an a% i5i as i"osinase )an !e!,en #% ("an#l !elanin0 G"an#l !elanin ,e"!i("asi %e a"a& +#l#"an !elanosi )an !as#% %e )ala! %e"a inosi 0

!elanosi

e"le a% )i ,a(ian ,a-a&* 'an( si o$las!an'a !en+#l#" %e

a as0 Melanin )i,en #% ole& !elanosi )ala! ,e,e"a$a a&a$0 Ke i%a )i,en #%* ("an#l !elanin !i("asi )i )ala! $e"l#asan si o$las!a !elanosi lal# )i "ans/e" %e %e"a inosi * e"# a!a $a)a la$isan s "a #! (e"!ina i5#! )an s "a #! ,an'a% !en(an)#n( !elanin* ,a&%an le,i& s$inos#!0 Ke"a inosi !e"#$a%an sel.sel 'an( !e!,en #% +a"in(an e$i)e"!is0 A%i,a n'a sel.sel %e"a inosi ,an'a% )a"i$a)a 'an( e")a$a $a)a !elanosi 'an( !e"#$a%an $en(&asil !elanin i # sen)i"i0 A" in'a* !elanosi )i si # &an'a ,e" #(as !e!,e"i -a"na $a)a %e"a inosi 0 Melanin 'an( )i e"i!a ole& %e"a inosi * la!a.%ela!aan a%an )i1e"na ole& lisoso! )i )ala! %e"a inosi %a"ena !#n(%in )ian((a$ se,a(ai ,en)a asin(0 Ini !en'e,a,%an sel.sel %e"a inosi $a)a la$isan e$i)e"!is ,a(ian a as i)a% !en(an)#n( !elanin0 3a)i* se ela& !elanosi ,e"s#sa& $a'a& !en+#l#"%an si o$las!an'a )an !e!,e"i%an !elanin %e$a)a %e"a inosi * e"n'a a $a)a a%&i"n'a !elaninn'a )i!a%an ole& lisoso! $a)a %e"a inosi 0 Na!#n e"n'a a !elanosi i)a% sa%i &a i* ,a&%an )ia e a$ !en+alan%an #(asn'a !e!,e"i%an !elanin %e$a)a %e"a inosi 0 Se ela& !elanin )i "ans/e" %e %e"a inosi * !elanin i)a% )ile a%%an se1a"a se!,a"an(an* ("an#l !elanin ,e"a%#!#lasi )i )ala! si o$las!a )i )ae"a& a as in i $a)a %e"a inosi 0 A%#!#lasi !elanin )i )ae"a& a as in i ,#%an i)a% a)a /#n(sin'a* e a$i ,e" #+#an !elin)#n(i n#%le#s )a"i e/e% !e"#sa% "a)iasi #l "a5iole 0 N#%le#s 'an( !en(an)#n( DNA )i )ala!n'a ,isa !en(ala!i !# asi a$a,ila e"%ena "a)iasi #l "a5iole 0 Dan ini ,isa !en'e,a,%an e"+a)in'a %an%e" %#li 0 Selain $en+elasan )i a as* !an/aa )a"i !elanosi 'an( )ile a%%an )i ,a-a& a)ala& #n #% !en'ela!a %an !elanosi i # sen)i"i0 Sean)ain'a !elanosi ,e"a)a )i a as )an ,e" in)a% se,a(ai $a&la-an* %e"a inosi )i ,a-a&n'a !e!an( a%an e"lin)#n(i* e a$i !elanosi sen)i"i ,isa !en(ala!i %e"#sa%an a$a,ila "a)iasi 'an( )i$an1a"%an !a a&a"i e"lal# ,esa"0 3i%a !elanosi !en(ala!i %e"#sa%an* sel ini a%an la!a e"(an i%an )en(an 'an( ,a"#0 A%i,a n'a !elanin s#)a& i)a% ,isa )i&asil%an la(i %a"ena $en(&asil !elanin !en(ala!i %e"#sa%an0 A%an e a$i* +i%a !elanosi )ile a%%an )i ,a-a&* "a)iasi

#l "a5iole a%an )i a&an ole& !elanin 'an( ,e"a)a )i a asn'a0 3i%a "a)iasin'a e"lal# ,esa"* "a)iasi ini a%an !e"#sa% %e"a inosi se,el#! sa!$ai $a)a !elanosi 0 A" in'a %e"a inosi a%an )i%o",an%an le,i& )#l# se&in((a !elanosi ,isa e"sela!a %an0 Ka"ena %e"a inosi !e"#$a%an sel 'an( a% i/ !e!,ela& )an e"#s !e!$e",a"#i )i"i* -ala#$#n sel ini !en(ala!i %e"#sa%an* sel ini a%an )i(an i%an )en(an 'an( ,a"#0 Melanosi !en((#na%an 1a"a ini -ala#$#n &a"#s ,e"s#sa&.s#sa& !en+#l#"%an si o$las!an'a )an !en'e"a&%an !elanin %e$a)a %e"a inosi 0

"A#!AR PUS!A$A Al'a A!ila ;i "ie* 200:* Histologi Dari Melanosit* ;a%#l as Ke)o% e"an Ba(ian His olo(i Uni5e"si as S#!a e"a U a"a

3#n<#ie"a L02* 2a"nei"o 3* Kelle' R0O0 asi! Histolog"# $%th edition* Was&in( on* Lan(e* 2003= 31>.23 Ross M0H0 Histolog", A &e't And Atlas* Ne- ?o"%* Ha"$e" @ Ro- 1ABC=:1>.23 Bloo! @ ;a-1e 0 uku A(ar Histologi0 E)isi %e.12* 3a%a" a* Pene",i B#%# Ke)o% e"an EG2* 11AA: = C3>.:>

2o"!a1% D0H0 )ntrodu!tion to Histolog"0 P&ila)el$&ia* 30B0 Li$$in1o 2o!$an'* 1AB:=2AA.303 Re no Is-a"i T* 200D* uku Pegangan )lmu Pengetahuan *osmetik * 3a%a" a* G"a!e)ia P#s a%a U a!a