SISTEM ENDOKRIN TERDIRI DARI 1.

HYPOPHYSIS = PITVITARY GLAND PARS DISTALIS PARS INTERMEDIA PARS TUBERNALIS NEURO HYPOPHYSIS 2. THYROID GLAND 3. PARATHEROID GLANDS 4. SUPRARENAL GLANDS CORTEX MEDULA 5. PINEAL GLANDS = EPIPYSE THE HIPOPYSIS A. ADRENO HYPOPHYSIS ( GLANDULAR PORTION ) BER ARNA PINK DI BAGI OLEH RESIDUAL PARS DISTALIS ANTERIOR DAN CLE!T ") PARS TUBERNALIS LAN#UTAN PARS DISTALIS MENGELILINGI NEURAL STALK $) PARS INTERMEDIA DI POSTERIOR DARI CLE!T B. NEURO HYPOPHYSIS BER ARNA PUTIH ") PARS NERVOSA ( IN!UNDIBULAR PROSES ) POSTERIOR DARI PARS INTERMEDIA $) IN!UDIBULAR STEM DI ATAS PARS NERVOSA %) MEDIAN EMINENCE O! THE TUBBER CINEREUM ( $ & % = IN!UNDIBULAR STALK = NEURAL STALK ) (IM!UNDUBULAR STALK & PARS TUBERNALIS = HYPOPHESEAL STALK ) ADENO HYPOPHYSIS ' 1. PARS DISTALIS 2. PARS TUBERNALIS 3. PARS INTERMEDIA NEUROHYPOPHYSIS ' 1. PARS NERVOSA 2. IN!UNDIBULAR STEM 3. MEDIAN EMINENCE

PARS DISTALIS (5) PARENCHYM NYA DIBENTUK OLEH ANASTOMA*ING CORDSDAN CLUSTERNYA O! EPITHELIAL CELLS+ DIANTARANYA DI DAPATKAN ' SINUSOIDAL CAPILLARIES A. CHROMOPHOBES = CHIE! OR C CELLS 5,) SEBAGAI RESERVE CELLS ( DPTMENGAHSILKAN CHROMOPHIL) SMALL ROUNDED OR POLYGONAL CELLS LITTLE CYTOPLASM +LACK+O! SPECI!IC GRANULES BATAS - BATAS SEL NYA TIDAK #ELAS MEMBENTUK KELOM.OK DI TENGAH B. CHROMOPHILS 1. ACIDOPHILS ( ALPHA CELL ) 35) LEBIH BESAR DARI PADA CHROMOPHOBES BATAS - BATAS SEL NYA TAMPAK #ELAS SPECI!IC GRANULESNYA DAPAT DI CAT DENGAN EOSIN SEMATOTROPES DALAM KELOMPOK MENGHASILKAN ' GRO TH - HORMON ( STH = SOMATOTROPIN ) MAMMOTROPES ' MENGHASILKAN ' LACTOGENIC HORMONE (PROLACTIN + LUTEOTROPIC H - LTH ) 2. BASOPHILS ( BETA CELLS ) 15) LEBIH BESAR DARI PADA ACIDOPHILS DPT DI CAT METHYLENE BLUE PAS POSITIVE THYROTROPES ( BETA BASOPHILS ) SECRETE THYROTROPIC ( TYROID STIMULATING ) GONADOTROPES ( DELTA BASOPHILS ) SECRETE ' !OLLICLE STIMULATING H = !SH LUTEINI*INA H ( L H ) INTERSTITIAL CELLS STIMULATING H ( ICSH ) CORTICOTROPIS ' ACTH AND LPH

PARS INTERMEDIA 2) LAPISAN TIPIS SEL NYA MENGANDUNG VESICLE BERISI COLLOID SEL NYA MENYERUPAI CHROMOPHOBES DAN CORTICOTROPES PRODUCES ' INTERMEDDIN MELANOCYTE STIMULATING H ( MSH ) ( PADA AMBPHIBIANS DAN IKAN ) PRODUKSI MELANIN PARS TUBERNALIS MEMBENTUK COLLAR O! CELLS MENGELILINGI IN!UNDIBULAR STALK CELLS NYA MENYERUPAI ' ACIDHOPHILS +BASOPHILSDAN CHROMOPHOBES CELLS NEURO HYPOPHYSIS MELIPUTI MEDIAN EMINENCE O! TUBBER CINEREUM+ IN!UNDIBULAR STALK DAN PARS NERVOSA SEL - SEL PITUICYTES HERIN/S BODIES = SECRETION O! UNMYELINATED NERVE HYPOTHALAMO HYPOPHYSEAL TRACT MELA ATI IN!UNDIBULAR STEM+ BERAKHIR DI PARS NERVOSA ( CELL BODIES ) TERLETAK DI DALAM SUPRA OPTIC DAN PARAVENTICULAR NUCLEI DARI HYPOTHALAMUS) II . KEL THYROID TERDIRI DARI 2 LATENAL LOBEES + DI HUBUNGKAN OLEH ISTHMUS SELAPIS SEL MEMBATASI !OLLICLE+ YANG BERISI COLLOID DUA #ENIS !OLLICULAR CELLS ") PRINCIPAL OR !OLLICULAR CELLS TRIODOTHYRONIN = T3 TETRALODOTHYRONIN+ TYROXINE = T4 $) PARA !OLLICULAR CELLS = C CLEAR OR LIGHT CELLS THYRO CALCITONIN PRINCIPLE CELLS BIASANYA CUBOIDAL HYPOACTIVE 0 CELLS ARE LO COLLOID STAINED ACIDOPHILS HYPERACTIVE 0 CELLS ARE HIGH COLLOID STAINED BASOPHILS DELICATE BASAL LAMINA !RESH COLLOID IS HOMOGENOUS+CLEAR+VISCOUS CONTAIN THYROGLOBULIN AND EN*YMES CYTOPLASM IN BASOPHILS

PARA !OLLICULAR CELLS INTRA AND EXTRA EPITHELIAL TERLETAK DI DEKAT !OLLICLE+ DI DALAM BASAL LAMINA TIDAK MENON#OL KE DALAM LUMEN LEBIH BESAR NUCLEI TERLETAK ECCENTRICALLY MENGHASILKAN ' THYROCALCITONIN ( CALCITONIN ) III . KEL PARATHEROID T O PAIRS +TERLETAK SANGAT DEKAT DENGAN KEL THYROID EPITHELIAL CELLS 2 TYPES 1. CHIE! O! PRINCIPAL CELLS 2. OXYPHIL CELLS PRINCIPAL CELLS LEBIH BANYAK LARGE VESICULAR NUCLEL + CENTRALY PLACED CLEAR+PALE STAINING CYTOPLASM+CONTAIN LIPO!USCIN GRANULES OXYPHILS CELLS MINOR PORTION OCCUR SINGLY OR IN SMALL GROUP SMALL DARKLY STAINING NUCLEL +O!TEN APPEAR PYKNOTIC CYTOPLASM IS STRONGLY ACIDOPHILS PRODUSES PARATYROID H ( PARA PHORMENE ) IV. KEL SUPRARENAL = KEL. A DRENAL 1. CORTEX ' YELLO 2. MEDULLA ' REDDISH BRO N CORTEX ' 1. OUTER *ONE ' *ONA GLOMERULICA = 15) 2. MIDDLE *ONE ' *ONA !ASCICULATA =(1) 3. INNER *ONE ' *ONA RETICULARIS = () *ONA GLOMEROLISA IMMEDIARELY BENEATH THE CAPSULE CONSIST O! PYRAMIDAL OR COLUMNAR CELLS ARRANGED IN OVOID GROUP DEEPLY STAINING SPHERICAL NUCLEL CYTOPLASM IS ACIDOPHILS *ONA !ASCICULATA THICKEST LAYER O! THE CORTEX LARGE +IRREGULAR CUBOIDAL OR POLI HEDRAL CELLS +ARRANGED IN LONG +RADIAL CORDS USUALLY ONE OR T O CELLS IDE CRO DED ITH LIPID DROPLETS +THE CELLS APPEAR VACUOLATED AND HAVE A SPONGY APPEAR +CALLED 2 SPONGIOCYTES . *ONA RETICULARIS

 ANASTOMASING CORDS CELLS ARE SMALLER THAN THOSE O! *ONA !ASCICULATA MEDULLA ' CELLS ARE LARGE AND OVOID OR POLYHEDRAL OCCURS IN GROUPS OR SHORT ANASTOMASING CORDS CHROMA!!IN REACTION 0 CELLS ARE CALLED CHROMA!!IN ( PHEOCHROME ) CELLS CATECHOLAMINE EPINEPHRINE AND NOR EPI NEPHRINE CAONTAINS A !E SCATTERED AUTOMATIC GANGLION CELLS THE PARA GANGLIA = CHROMA!!IN SYSTEM LIE RETRO PERITO NEALLY PARA CORTIC BODIES O! *ULKER KAND THE PINEAL GLANDS = EPIPHYSEAL CEREBRI THE LOBULE ARE COMPOSED O! ' EPITHELIAL CELLS = PINEAL OCYTES GLIAL OR INTERSTITAL CELLS PINEALOCYTES ' PROSSES KARGE LOBULATED NUCLEUS PROMINENT NUCLEOL GLIAL CELLS SUPPORTING ELEMENTS !E ER IN NUMBER NECLEUS ARE ELONGATED AND STAIN MORE DEEPLY THE APPEARANCE O! A STROCYTES BRAIN SAND = CORPORA ARENACEA = ACERVULLI ARE CONCRETIONS THAT APPEAR MAINLY IN THE CAPSULE AND SEPTA LAMOLLATED BODIES COMPOSED PRIMAIRLY O! CALCIUM CARBONATE AND PHOSPHATE ITH HIN ORGANIC MATRIX TO SECRETE MELATOHIN IN !LUENCE UPON GONADAL DEVELOPMENT