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Ondansentron

Dewasa: PO Mual dan muntah yang


berhubungan w / kanker kemoterapi 24
mg sebagai dosis tunggal, 30 menit
sebelum dimulainya satu hari kemoterapi.
Mencegah
tertunda
emesis
setelah
kemoterapi 8 tawaran mg sampai 5 hari
setelah
akhir
kursus
kemoterapi.
Profilaksis mual akibat kemoterapi dan
muntah kemoterapi kanker emetogenik
Moderat: Awal: 8 mg 30 menit sebelum
kemoterapi; dosis ulangan 8 jam setelah
dosis awal, kemudian 8 mg 12 Hrly selama
1-2 hari setelah selesai kemoterapi.
Sangat emetogenik kemoterapi kanker: 24
mg sebagai dosis 30 menit kemoterapi
sebelumnya tunggal. Profilaksis pasca-op
mual dan muntah 16 mg 1 jam sebelum
anaesth; atau 8 mg 1 jam sebelum
anaesth diikuti oleh 2 lebih dosis 8 mg
pada tiap 8 jam. Mual dan muntah yang
berhubungan w / kanker kemoterapi atau
radioterapi
Kurang
emetogenik
kemoterapi dan / atau radioterapi: 8 mg 2
jam sebelum pengobatan diikuti dengan 8
mg 8-12 jam kemudian. Profilaksis mual
dan muntah yang berhubungan w dosis
biasa / terapi radiasi: 8 mg tid. Menjalani
Total iradiasi tubuh: 8 mg 1-2 jam sebelum
masing-masing fraksi terapi setiap hari.
Menjalani dosis tinggi terapi radiasi fraksi
tunggal untuk perut: 8 mg 1-2 jam
sebelum radiasi, ulangi dosis tiap 8 jam
selama 1-2 hari setelah selesai terapi.
Menjalani
radiasi
harian
difraksinasi
dengan perut: 8 mg 1-2 jam sebelum
radiasi, kemudian tiap 8 jam; ulangi terapi
setiap hari. IV / IM Mual dan muntah yang
berhubungan w / kanker kemoterapi
kemoterapi Sangat emetogenik: 8 mg
sebagai IM dosis tunggal atau injeksi IV
lambat segera sebelum pengobatan; atau
8 mg IM atau inj IV lambat diberikan
segera
sebelum
pengobatan
diikuti
dengan baik infus IV kontinu 1 mg / hr
sampai 24 jam atau dengan 2 lebih lanjut
dosis 8 mg 2-4 jam terpisah; atau 32 mg
sebagai dosis tunggal melalui infus IV

selama 15 menit segera sebelum


pengobatan; atau 150 mcg / kg IV infus
selama 15 menit (mulai 30 menit sebelum
kemoterapi) dan diulang 4 dan 8 jam
setelah dosis 1. khasiat anti-muntah dapat
ditingkatkan
dengan
memberikan
deksametason natrium fosfat 20 mg IV
sebelum kemoterapi. Profilaksis mual
akibat kemoterapi dan muntah Awal: 0,15
mg / kg (sampai dengan max 16 mg /
dosis) diberikan sebagai infus 15-min IV
30 menit sebelum kemoterapi; ulangi dua
kali di 4 Hrly setelah dosis awal.
Pengobatan dan profilaksis pasca-op mual
dan muntah 4 mg sebagai dosis tunggal
melalui IM atau 4-8 mg lambat inj IV di
induksi anaesth. Dubur Mual dan muntah
terkait kemoterapi w / kanker Sebagai
supp: 16 mg 1-2 jam sebelum perawatan.
Mencegah
tertunda
emesis
setelah
kemoterapi Sebagai supp: 16 mg sekali
sehari sampai 5 hari setelah akhir kursus
kemoterapi
Dosage Detail
Intravenous
Prophylaxis
of
chemotherapy-induced
nausea and vomiting
Adult: Initially, 0.15 mg/kg (up to max 16
mg/dose) given as 15-min infusion 30 min
prior to chemotherapy; repeat twice at 4
hrly after initial dose.
Child: 6 mth Same as adult dose.
Elderly: No dosage adjustment needed.

Oral
Prophylaxis of nausea and vomiting
associated with radiation therapy
Adult: Usual dose: 8 mg tid. Undergoing
total body irradiation: 8 mg 1-2 hr prior to
each fraction of therapy daily. Undergoing
single high-dose fraction radiation therapy

to the abdomen: 8 mg 1-2 hr prior to


radiation, repeat dose 8 hrly for 1-2 days
after completion of therapy. Undergoing
daily fractioned radiation to the abdomen:
8 mg 1-2 hr prior to radiation, then 8 hrly;
repeat therapy daily.
Elderly: No dosage adjustment needed.

Oral
Prevent
delayed
chemotherapy

emesis

following

Adult: 8 mg bid, for up to 5 days after the


end of a course of chemotherapy.
Elderly: No dosage adjustment needed.

Oral
Prophylaxis
of
chemotherapy-induced
nausea and vomiting
Adult:
Moderate
emetogenic
cancer
chemotherapy: Initially, 8 mg 30 min prior
to chemotherapy; repeat dose 8 hr after
initial dose, then 8 mg 12 hrly for 1-2 days
after completion of chemotherapy. Highly
emetogenic cancer chemotherapy: 24 mg
as a single dose 30 min prior to
chemotherapy.
Child:
Moderate
emetogenic
cancer
chemotherapy: 4-11 yr Initially, 4 mg 30
min prior to chemotherapy; repeat dose at
4 and 8 hr after the initial dose, then 4 mg
8 hrly for 1-2 days after completion of
chemotherapy.
Elderly: No dosage adjustment needed.

Oral
Nausea and vomiting associated with
cancer chemotherapy or radiotherapy
Adult: Less emetogenic chemotherapy
and/or radiotherapy: 8 mg 2 hr prior to
treatment followed by 8 mg 8-12 hr later.
Elderly: No dosage adjustment needed.

Oral
Prophylaxis of postoperative nausea and
vomiting
Adult: 16 mg taken 1 hr prior to anaesth;
or 8 mg taken 1 hr prior to anaesth
followed by 2 more doses of 8 mg 8 hrly.
Elderly: No dosage adjustment needed.

Oral
Nausea and vomiting
cancer chemotherapy

associated

with

Parenteral

Adult: 24 mg as a single dose, 30 min prior


to the start of single-day chemotherapy.

Nausea and vomiting


cancer chemotherapy

Child: 4-11 yr 4 mg 30 min prior to


chemotherapy; repeat dose at 4 and 8 hr
after initial dose, then 4 mg tid for 1-2
days after completion of chemotherapy.

Adult: Highly emetogenic chemotherapy: 8


mg as a single dose, given IM or slow IV inj
immediately prior to treatment; or 8 mg IM
or slow IV inj given immediately prior to
treatment followed by either continuous IV
infusion of 1 mg/hr for up to 24 hr or by a
further 2 doses of 8 mg 2-4 hr apart; or 32
mg as a single dose via IV infusion over

Elderly: No dosage adjustment needed.

associated

with

15 min immediately prior to treatment;


or 150 mcg/kg IV infusion over 15 min
(beginning 30 min prior to chemotherapy)
and repeated 4 and 8 hr after the 1st
dose.
Anti-emetic
efficacy
can
be
enhanced by giving dexamethasone
sodium phosphate 20 mg IV prior to
chemotherapy.
Child: 6 mth 150 mcg/kg via IV infusion
30 min prior to the start of chemotherapy,
repeat dose at 4 and 8 hr after the initial
dose.

Rectal
Nausea and vomiting
cancer chemotherapy

associated

with

Adult: As supp: 16 mg given 1-2 hr prior to


treatment.
Elderly: No dosage adjustment needed.

Rectal

Elderly: No dosage adjustment needed.

Prevent
delayed
chemotherapy

Parenteral

Adult: As supp: 16 mg once daily, for up to


5 days after the end of a course of
chemotherapy.

Treatment
and
prophylaxis
postoperative nausea and vomiting

of

following

Elderly: No dosage adjustment needed.

Adult: 4 mg as a single dose via IM or 4-8


mg slow IV inj at induction of anaesth.
Child: 1 mth 100 mcg/kg by slow IV inj.
Max: 4 mg.
Elderly: No dosage adjustment needed.

emesis

Omeprazole

Lasix

Aminefron