DAFTAR ISI

Halaman
KATA PENGANTAR...................................................................................

DAFTAR ISI.................................................................................................

ii

DAFTAR TABEL.........................................................................................

xv

BAB I PENDAHULUAN...........................................................................

1.1

Latar Belakang........................................................................

1.2

Tujuan ....................

1.3

Manfaat...................................................................................

BAB II TINJAUAN PUSTAKA.................................................................

2.1

Analgetik.................................................................................

2.1.1 Opioid............................................................................

2.1.2 Fentanyl.........................................................................

Kulit........................................................................................

2.2.1 Anatomi Kulit..............................................................

2.2.2 Absorpsi perkutan........................................................

2.2.3 Aspek Teori Perlintasan...............................................

11

2.2.4 Difusi Franz.................................................................

12

Sediaan Transdermal...............................................................

13

2.3.1 Syarat Sediaan Transdermal........................................

13

2.3.2 Keuntungan Sediaan Transdermal...............................

14

2.3.3 Kerugian Sediaan Transdermal....................................

14

Transdermal Patch..................................................................

14

2.4.1 Tipe Transdermal Patch...............................................

15

2.4.2 Komponen utama Sediaan Patch.................................

16

2.5

Penghantaran obat melalu Transdermal..

19

2.6

Studi In Vitro Sediaan Transdermal....

20

2.7

Sel Difusi............................................

20

2.8

Membran Permeasi.............................

21

2.9

Kinetik Pelepasan Obat.......................

21

2.2

2.3

2.4

BAB III TINJAUAN UMUM SENYAWA AKTIF...................................

3.1

24

Deskripsi Umum Fentanyl......................................................

24

3.2.1 Sifat Fisiko Kimia.........................................................

24

BAB IV TINJAUAN FARMAKOLOGI...................................................

25

4.1 Golongan Obat berdasarkan Farmakoterapi...........................

25

4.2 Indikasi Dan Alasan................................................................

25

4.3 Mekanisme Kerja Obat...........................................................

25

4.4 Farmakokinetik Fentanyl Patch..............................................

26

4.5 Farmakodinamik Fentanyl Patch............................................

26

4.6 Dosis dan Cara Pemberian......................................................

26

BAB V PENUTUP......................................................................................

33

5.1

Kesimpulan.............................................................................

33

5.2

Saran.......................................................................................

33

DAFTAR PUSTAKA....................................................................................

34

LAMPIRAN ..............................................................................................

37