Bab 22.
lah Kelompok isokinolin dengan struktur
Kimiawi dan khasiat amat berlainan (al.
ron-narkotik), yakni papwoerin. noskapin (=
rarkotin) dan narsin. Morfin. berkhasiat
analgetis sangat kat, lagi pula memilihi
refleks batuk, yang semuanya berdasarkan
supresi sususan saraf pusat (SSP). Morfin
juga menimbulkan efek stimulasi SSP, mis.
miosis (pencivtan pupil mata), csitasi dat
somondsi. aya stimulasinya pada CTZ meng-
akibatkan mual dan muntak-muntah. Efek
perifernya yang penting adalah obstipasi,
retensi kemih dan pelepasan histamin yang,
mengakibatkan vasodilatasi pembuluh kulit
ddan gatal-gatal (urticaria).
Perggumannya khusus pada nyeri hebat
akut dan kronis. seperti pasca-bedah dan se-
telah infark jantung, juga pada fase terminal
dari kanker. Banyak digunakan scbagaitablet
retard untuk kerjanya
‘Resorpsinya di usus baik, telapi BA-nya he-
nya kl. 25% akibat FPE besar. Mulai kerjanya,
setelah 1-2 jam dan bertahan sampai 7 jam.
Resorpsi dari suppositoria umumnya sedikit
lebih bik secara 8 /i.m. baik sekali. PP-nya
35%; dalam hati 70% dari morfin dimeta-
bolisasi melalui senyawa konyugasi dengan
asam glukuronat menjadi morfin-3-gluku-
ronida yang tidak aktif dan hanya sebagian
ecil (3%) dari jumlah ini terbentuk morfin-
@glukuronida dengan daya kerja analgetis
Jebih kuat dari morfin sendiri. Ekskresinya
melalui kemih, empedu dengan situs entero-
hepatis dan tin
‘Antidote, Pada intoksikasi digunakan an-
(agonis morfin sebagai antidotum, yaknk
nalokson, lihat nr 6.
Dosis: dewasa oral 3-6
Anda mungkin juga menyukai
- Shoe Dog: A Memoir by the Creator of NikeDari EverandShoe Dog: A Memoir by the Creator of NikePenilaian: 4.5 dari 5 bintang4.5/5 (537)
- The Yellow House: A Memoir (2019 National Book Award Winner)Dari EverandThe Yellow House: A Memoir (2019 National Book Award Winner)Penilaian: 4 dari 5 bintang4/5 (98)
- Summary Vulvitis Gilang 1807101030011Dokumen10 halamanSummary Vulvitis Gilang 1807101030011GilangBelum ada peringkat
- Rhinitis AlergiDokumen15 halamanRhinitis AlergiGilangBelum ada peringkat
- DifteriDokumen50 halamanDifteriGilangBelum ada peringkat
- Sempro GilangDokumen38 halamanSempro GilangGilangBelum ada peringkat
- To Handle This:: While DPS Are Dealing With Steam Regulators (4 Rooms) Tank SwapDokumen3 halamanTo Handle This:: While DPS Are Dealing With Steam Regulators (4 Rooms) Tank SwapGilangBelum ada peringkat
- The Subtle Art of Not Giving a F*ck: A Counterintuitive Approach to Living a Good LifeDari EverandThe Subtle Art of Not Giving a F*ck: A Counterintuitive Approach to Living a Good LifePenilaian: 4 dari 5 bintang4/5 (5794)
- The Little Book of Hygge: Danish Secrets to Happy LivingDari EverandThe Little Book of Hygge: Danish Secrets to Happy LivingPenilaian: 3.5 dari 5 bintang3.5/5 (400)
- Grit: The Power of Passion and PerseveranceDari EverandGrit: The Power of Passion and PerseverancePenilaian: 4 dari 5 bintang4/5 (588)
- Elon Musk: Tesla, SpaceX, and the Quest for a Fantastic FutureDari EverandElon Musk: Tesla, SpaceX, and the Quest for a Fantastic FuturePenilaian: 4.5 dari 5 bintang4.5/5 (474)
- A Heartbreaking Work Of Staggering Genius: A Memoir Based on a True StoryDari EverandA Heartbreaking Work Of Staggering Genius: A Memoir Based on a True StoryPenilaian: 3.5 dari 5 bintang3.5/5 (231)
- Hidden Figures: The American Dream and the Untold Story of the Black Women Mathematicians Who Helped Win the Space RaceDari EverandHidden Figures: The American Dream and the Untold Story of the Black Women Mathematicians Who Helped Win the Space RacePenilaian: 4 dari 5 bintang4/5 (895)
- Team of Rivals: The Political Genius of Abraham LincolnDari EverandTeam of Rivals: The Political Genius of Abraham LincolnPenilaian: 4.5 dari 5 bintang4.5/5 (234)
- Never Split the Difference: Negotiating As If Your Life Depended On ItDari EverandNever Split the Difference: Negotiating As If Your Life Depended On ItPenilaian: 4.5 dari 5 bintang4.5/5 (838)
- The Emperor of All Maladies: A Biography of CancerDari EverandThe Emperor of All Maladies: A Biography of CancerPenilaian: 4.5 dari 5 bintang4.5/5 (271)
- Devil in the Grove: Thurgood Marshall, the Groveland Boys, and the Dawn of a New AmericaDari EverandDevil in the Grove: Thurgood Marshall, the Groveland Boys, and the Dawn of a New AmericaPenilaian: 4.5 dari 5 bintang4.5/5 (266)
- On Fire: The (Burning) Case for a Green New DealDari EverandOn Fire: The (Burning) Case for a Green New DealPenilaian: 4 dari 5 bintang4/5 (74)
- The Unwinding: An Inner History of the New AmericaDari EverandThe Unwinding: An Inner History of the New AmericaPenilaian: 4 dari 5 bintang4/5 (45)
- Rise of ISIS: A Threat We Can't IgnoreDari EverandRise of ISIS: A Threat We Can't IgnorePenilaian: 3.5 dari 5 bintang3.5/5 (137)
- The Hard Thing About Hard Things: Building a Business When There Are No Easy AnswersDari EverandThe Hard Thing About Hard Things: Building a Business When There Are No Easy AnswersPenilaian: 4.5 dari 5 bintang4.5/5 (345)
- The World Is Flat 3.0: A Brief History of the Twenty-first CenturyDari EverandThe World Is Flat 3.0: A Brief History of the Twenty-first CenturyPenilaian: 3.5 dari 5 bintang3.5/5 (2259)
- The Gifts of Imperfection: Let Go of Who You Think You're Supposed to Be and Embrace Who You AreDari EverandThe Gifts of Imperfection: Let Go of Who You Think You're Supposed to Be and Embrace Who You ArePenilaian: 4 dari 5 bintang4/5 (1090)
- The Sympathizer: A Novel (Pulitzer Prize for Fiction)Dari EverandThe Sympathizer: A Novel (Pulitzer Prize for Fiction)Penilaian: 4.5 dari 5 bintang4.5/5 (121)
- Her Body and Other Parties: StoriesDari EverandHer Body and Other Parties: StoriesPenilaian: 4 dari 5 bintang4/5 (821)
