DAFTAR ISI

DAFTAR ISI........................................................................................................................i

DAFTAR GAMBAR..........................................................................................................iii

DAFTAR TABEL...............................................................................................................iv

BAB I PENDAHULUAN

1.1 Latar Belakang..................................................................................................1

1.2 Rumusan Masalah............................................................................................3

1.3 Hipotesis Penelitian..........................................................................................3

1.4 Tujuan Penelitian..............................................................................................4

1.4.1 Tujuan umum..........................................................................................4

1.4.2 Tujuan khusus.........................................................................................4

1.5 Manfaat Penelitian............................................................................................4

1.5.1 Manfaat bagi ilmu pengetahuan..............................................................4

1.5.2 Manfaat bagi pelayanan kesehatan........................................................4

BAB II TINJAUAN PUSTAKA

2.1. Kista Ovarium.................................................................................................6

2.1.1 Definisi..................................................................................................6

2.1.2 Insiden dan Prevalensi.........................................................................6

2.1.3 Faktor Resiko........................................................................................7

2.1.4 Etiologi..................................................................................................8

2.1.5 Klasifikasi............................................................................................11

2.1.6 Penatalaksanaan................................................................................14

2.1.7 Stadium Kanker Ovarium...................................................................16

2.2 Matriks Metalloproteinase................................................................................17

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 2.2.1 Struktur MMP-9.......................................................................................20

2.2.2 Ekspresi MMP-9.....................................................................................21

2.2.3 Peranan MMP-9 dalam Tumor...............................................................24

2.2 Kerangka Teori..................................................................................................32

2.3 Kerangka konsep..............................................................................................32

BAB III Metodologi Penelitian.......................................................................................33

3.1 Rancangan Penelitian.......................................................................................33

3.2 Tempat dan waktu penelitian............................................................................33

3.3 Populasi dan subjek penelitian.........................................................................33

3.4 Kriteria Inklusi dan Eksklusi penelitian.............................................................34

3.5 Identifikasi Variabel...........................................................................................35

3.6 Cara Kerja Dan Teknik Pengambilan Data.......................................................37

3.7 Rancangan Analisis...........................................................................................37

3.8 Alur Penelitian...................................................................................................38

3.9 Etika penelitian................................................................................................38

BAB IV Hasil dan Pembahasan..................................................................................39

DAFTAR PUSTAKA........................................................................................................41

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 DAFTAR GAMBAR

Gambar 1. Pembagian Tumor Ovarium menurut sel asalnya.........................................12

Gambar 2. Alur penatalaksanaan tumor ovarium ganas.................................................15

Gambar 3. Proses angiogenesis.....................................................................................28

Gambar 4. Peranan MMP-9 dalam angiogenesis...........................................................28

Gambar 5. Fungsi fungsi MMP di dalam progresi kanker...............................................28

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 DAFTAR TABEL

Tabel 1. Definisi Operasional...........................................................................................35

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