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UJI EFEKTIVITAS EKSTRAK DAUN JAMBU BIJI (Psidium Guajava. L)

TERHADAP PERTUMBUHAN Pityrosporum ovale SECARA IN VITRO

Skripsi
untuk memenuhi sebagian persyaratan
mencapai gelar Sarjana Kedokteran

Oleh :

Fadhila Nurrahma
30101306938

FAKULTAS KEDOKTERAN
UNIVERSITAS ISLAM SULTAN AGUNG
SEMARANG
2016
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SKRIPSI

UJI EFEKTIVITAS EKSTRAK DAUN JAMBU BIJI (Psidium Guajava. L)

TERHADAP PERTUMBUHAN Pityrosporum ovale SECARA IN VITRO

Yang dipersiapkan dan disusun oleh

Fadhila Nurrahma

30101306938

telah dipertahankan di depan Dewan Penguji

pada tanggal ........................
dan dinyatakan telah memenuhi syarat

Susunan Tim Penguji

Pembimbing I Anggota Tim Penguji

dr. Hj. Pasid Harlisa, Sp. KK dr. Ridha Wahyutomo, Sp. MK

Pembimbing II

dr. Ulfah Dian Indrayani, M.Sc dr. Qathrunnada Djam’an, M.Si.Med.

Semarang, ........................
Fakultas Kedokteran
Universitas Islam Sultan Agung
Dekan,

...................................................
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DAFTAR ISI

Usulan Skripsi .............................................................................................................................. ii

DAFTAR ISI ............................................................................................................................... iii

DAFTAR GAMBAR .................................................................................................................. v

DAFTAR TABEL

DAFTAR SINGKATAN ........................................................................................................... ix

BAB I PENDAHULUAN ................................................................................................. 1

1.1 Latar Belakang ................................................................................................ 1

1.2 Rumusan Masalah ........................................................................................... 3

1.3 Tujuan Penelitian............................................................................................. 3

1.3.1 Tujuan Umum ....................................................................................... 3

1.3.2 Tujuan Khusus....................................................................................... 3

1.4 Manfaat Penelitian........................................................................................... 4

1.4.1 Manfaat Teoritik .................................................................................... 4

1.4.2 Manfaat Praktis ..................................................................................... 4

BAB II TINJAUAN PUSTAKA....................................................................................... 5

2.1 Pityrosporum ovale. ........................................................................................ 5

2.1.1. Definisi................................... .............................................................. 5

2.1.2. Morfologi .............................................................................................. 5

2.1.3. Taksonomi. ........................................................................................... 7

2.1.4. Etiopatogenesis Ketombe ..................................................................... 7

2.2 Faktor yang mempengaruhi pertumbuhan P.ovale................................. ....... 9

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2.3 Daun Jambu Biji (Psidium guajava L). ........................................................ 10

2.2.1. Definisi ............................................................................................... 10

2.2.2. Taksonomi. ......................................................................................... 11

2.2.3. Morfologi ............................................................................................ 11

2.2.4. Kandungan ......................................................................................... .12

2.4 Mekanisme Daun Jambu Biji Sebagai Antijamur ........................................ 13

2.5 Ketokonazol ................................................................................................. 15

2.6 Metode Difusi ............................................................................................... 17

2.7Kerangka Teori............................................................................................... 18

2.8 Kerangka Konsep .......................................................................................... 19

2.9 Hipotesis........ ................................................................................................ 19

BAB III METODE PENELITIAN.................................................................................. 20

3.1 Jenis Penelitian .............................................................................................. 20

3.2 Variabel dan Definisi Operasional ................................................................ 20

3.2.1 Variabel................................................................................. .............. 20

3.2.2 Definisi Operasional.............................................................. .............. 20

3.3 Subjek Uji............................................................................................. ......... 21

3.4 Instrumen Penelitian............................................................................. ......... 22

3.5 Bahan Penelitian............................................................................................ 23

3.6 Cara Penelitian...................................................................................... ........ 24

3.7 Alur Penelitian............................................................................................... 29

3.8 Tempat dan Waktu................................................................................ ........ 30

3.9 Analisis Hasil........................................................................................ ........ 30

BAB IV HASIL PENELITIAN DAN PEMBAHASAN ....................................................

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4.1 Hasil Penelitian .................................................................................................

4.2 Pembahasan .......................................................................................................

BAB V KESIMPULAN DAN SARAN ..............................................................................

5.1 Kesimpulan........................................................................................................

5.2 Pembahasan .......................................................................................................

DAFTAR PUSTAKA............................................................................................. ......... 31

LAMPIRAN. .......................................................................................................................
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DAFTAR GAMBAR

Gambar 2.1.JamurPityrosporumovale .............................................................................. 6

Gambar 2.2.StrukturDinding&MembranSelJamur ........................................................... 7

Gambar 2.3.DaunJambuBiji (Psidiumguajava) .............................................................. 12

Gambar 2.4 Struktur Antifungi Ketokonazol .................................................................. 16

Gambar 2.5 Mekanisme Kerja Ketokonazole........................................................... ...... 17

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DAFTAR TABEL
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DAFTAR SINGKATAN

SDA : Sabouraud Dextrose Agar

SPSS : Statistical Product and Service Solutions