Suraya Anak Jihes BPF2017-2901

Brenda Liaw Hui Ling BPF2017-2880

Addler Ronald Anak Rambee BPF2017-2875

Ambilan : Julai 2017

Penyelaras Kumpulan : Pn. Dalila bt Dol
Tarikh Menghantar Tugasan : 28.03.2018

MECHANISM
CATEGORY MOA GENERIC TRADE

Alu-Cap

Maalox
Aluminium
Hydroxide

Mucogel

i. Meneutralkan HCl Magnesium

Antasid (Anti Asid) Carbonate
ii. Inhibit pepsin(nyahaktif pada PH5)
 i. Meneutralkan HCl
Antasid (Anti Asid)
ii. Inhibit pepsin(nyahaktif pada PH5)

Aromatic
Magnesium
Carbonate Oral
Suspension

Gelusil

Magnesium
Trisillicate (Tablet)

MMT

Cimetidine Tagamet

Zantac

H2 Receptor i. Halang Histamine H2 Receptor pada sel parietal untuk

Antagonist halang asid gastrik terhasil
Ranitidine
 Zantac

H2 Receptor i. Halang Histamine H2 Receptor pada sel parietal untuk

Antagonist halang asid gastrik terhasil
Ranitidine

Histac

Famotidine Pepcid

Lansoprazole
Prevacid
(30mg tablet)

* mengurangkan pengeluaran asid gastrik dengan

menghalang tindakan enzim gastrik H+ Potassium
Proton Pump
ATPase (H+/K+ - ATPase)
Inhibitor
* PPI bergabung dengan proton pump yang terletak pada
(PPIs)
sel membran di parietal dan merencat sekresi ion H+
 * mengurangkan pengeluaran asid gastrik dengan
menghalang tindakan enzim gastrik H+ Potassium
Proton Pump
ATPase (H+/K+ - ATPase)
Inhibitor
* PPI bergabung dengan proton pump yang terletak pada Omeprazole Losec
(PPIs)
sel membran di parietal dan merencat sekresi ion H+
dalam gastrik lumen

Esomeprazole Nexium

Rabeprazole Pariet

Pantoprazole Controloc

Propantheline
*Probanthine
Bromide

* Halang reseptor koligenik pada sel parietal, maka tiada

Anti muskarinic/
ransangan pada sel parietal
Anti koligernik/
* Halang acetycolin menduduki sel parietal
Antispamodic
* Kurangkan pengeluaran asid
 * Halang reseptor koligenik pada sel parietal, maka tiada
Anti muskarinic/
ransangan pada sel parietal
Anti koligernik/
* Halang acetycolin menduduki sel parietal Hyoscine
Antispamodic Buscopan
* Kurangkan pengeluaran asid Butylchloride

Dicyclomin HCl Bentylol, Lomine

Clarithromycin

* Bunuh dan hapuskan gram negative H.pylori

*Betamox
Amoxicillin *Beamoxy
Agen anti *Amoxy
mikrobial
 Agen anti
mikrobial

flagyl

Metronidazole

Amoxicillin 1000mg
+
TRIPPLE THERAPY REGIMEN Clarithromycin 500mg
+
( any 1 of PPIs Drug)

Sucralfate
* Menghalang selaput mucosa dan menghalang
kemasukan asid ke tapak ulcer serta menghalang
peluluhan (degradation) mucus oleh pepsin.
Agen pelindung
* Berasal dari aluminium (Bahan yang menyebabkan
mucosa
constipation)
* Menghalangpenipisan/mengekalkan tahap mucus atau
kepekatan mucus
Pink Bismuth

Bismuth
Subsallycylate
Pepto-Bismol
 Analog * Menghalang secresi HCl dan meransang pengeluaran
Misoprostol cytotec
Prostaglandins mucus dan bikarbonate
 DRUG INFO
KEKUATAN DOS INDICATION SIDE EFEFCT

1-2 tablet dikunyah QID

10-20 ml, 20-60 minit slepas

makan dan sebelum tidur * Dyspepsia
* Sembelit
* Hyperphosphatemia

10-20ml TDS, 20-60 minit slepas

makan dan sebelum tidur

*Dispepsia
 10ml TDS dalam air *Dispepsia

* Diarrhea

1-2 tablet dikunyah apabila perlu *Dispepsia

10ml TDS bersama air *Pedih Ulu Hati

* 800mg ON bagi rawatan 4-8

* Diarrhea ringan
H20
*Dispepsia( bukan ulcer) * Sakit Otot
* 200 mg * Pengekalan: 400mg ON
* Pening Kepala
* 400 mg * 800mg D.D.D
* 800 mg

* Ruam kulit
* Ginekomastia

* 150mg BD daily *Ulcerdenel

* 300mg OD *Ulcerbenign Gastric
* 150 mg
* 300 mg * 150mg BD daily
*Ulcer disebabkan NSAID
* 300mg OD * Takikardia
* Alapesia
* Visual Disturbance
* Vasculitis
* Pening
* 150 mg
* 300 mg
* Takikardia
* Alapesia
*Reflux * Visual Disturbance
150mg BD daily
*Esophagitis * Vasculitis
* Pening
* Sakit kepala
* 150mg BD * Ruam
* 300mg OD * Keletihan
* 150 mg
*suntikan IV perlahan = 50mg Chronic Episodic
* 300 mg
dicairkanhingga 20ml (diberi Dyspepsia
sekurang-kurangnya 2minit) 6-8
jam sehari

* Sakit kepala
* Pening
* 20 mg 40mg OD sebelum tdur * Diarrhea
* 40 mg 20mg BD * Sembelit
* Anxiety
* Confusion

1) 30mg od for 8 weeks

2) 30mg once 1-2 times for 4-8
weeks
3) 60-120mg once daily adjusted
* 15 mg according to the patient's
* 30 mg response
4) 30 mg bd in combination with
any of 2 antibiotics
(clarithromycin 500 mg bd,
amoxicillin 1g bd or
metronidazole 400mg bd) for 1-2
weeks
* Pancreatitis
* Anorexia
* Restlessness (Keletihan)
* Peptic ulcer disease
* Reflux oesophagitis
* Zollinger - Ellison syndrome
* For eridation of Helicobater
Pylori in combination with
antibiotic
 * Vertigo
* Penyakit reflux oesophangitis * Demam
* Dewasa: 20-120mg sekali
* Infeksi arabat jangkitan H. * Insomnia
* 10 mg sehari: Dos boleh diubah
Pylori * Dizziness
* 20 mg mengikut respon pesakit
* Zollinges - Ellison Syndrome * Abdominal Pain
* 40 mg * Kanak-kanak : 0.4-0.8
* Penyakit ulser peptik pada * Nausea
mg/kg/sehari
terapi konvensional * Diarrhea
* Muntah

* 20 mg
* 40 mg

* 20 mg
* 60 mg

*40 mg

* Kekejangan usus
* Sembelit
* Kekeringan mulut
*15mg * Urinary retention
* Adult or child over 12 years: * Sembelit
15mg TDS * Pedih ulu hati
* 30mg at night * Xerostamia
*Max: 120g
* Legakan secara
simpatomimetik bagi gangguan
GIT yang dikenalpasti melalui
simptom kekejangan otot
(spasm)
 * Legakan secara
simpatomimetik bagi gangguan * Anaphyxlaxis
* Adult: 10-20mg,TDS-QID GIT yang dikenalpasti melalui * Dry mouth
*10mg * Child 6-12 years old: 10 mg simptom kekejangan otot * Drowsiness
TDS (spasm) * Facial flushing photosensitiviti
* Constipation

* Dry mouth
*5mg * Constipation
* Adult: 80mg/day in 4 equally
*10mg * Urinary retention
divided doses (D.D.D)
*20mg * Headache
* Blurred Vision

*diarrhea
*abdominal pain
* 250mg *Nausea & vomitting
* 500 mg *dyspepsia
*abnormal taste
*headache

* 250 mg
*500 mg
*1000mg *hypersensitivity
*gastritis
stomatits
 * headache
*200 mg *vaginitis
*400 mg *nausea
*800 mg *metalic taste
*genital pruritus
*flu like symptom

(1+1+1)
Klacid HP7
BD untuk 1-2 minggu

*constipation
*nausea
* 2000mg BD daily * Duodenal ulcer dan non *upset stomach
*1000mg
* 1000mg QID daily malignan *dizziness
*backpain
*pruritus

*262mg chewable tablet * Sembelit

* heartburn *Pening
* GERD * Mulut kering
* stomach discomfort *rashes
*indigestion vertigo
 *diarrhoea
* 200 mcg/tab (BD-QID with
* abdominal pain
NSAIDS)
* flatulence
200mcg * 800 mcg od (in 2-4 d d) with
* nausea
main meals and at bedtime(4-8
* and vomitting
weeks)
* abdominal vagina bleeding
 CONTRA INDICATION DRUG INTERACTION

* Hypophospatemia
* Neonate & bayi
* Hypophospatemia
* Neonate & bayi

* Walfarin
* Phenytoin
* Propanolol
* Nifedipine
* Diazepam
* Lidocaine
* Theophylline
* Metronidazole

* Anticoagulant
* Triazolam
* Hipersensitiviti * Midazolam
* Ketaconazole
 * Anticoagulant
* Triazolam
* Hipersensitiviti * Midazolam
* Ketaconazole
* Sucralifate

* Cirrhosis of liver
* Antacid
* Impained rencil/ hepatitic function
* Diazepam
* Lactation

* Ampicillin
* Clarithromycin
* Digoxin
* Fluvoxamine
* Iron salt
* Ketaconazole
* Sucralfate

* Lactation
* Lactation

* Ampicillin
* Clarithromycin
* Calcium
* Diazepam
* Escitalopram
* Cyanocabalamin (Vit B12)

* Digoxin
* Hypersensitivity
* Ketaconazole
* Lactation
* Iron salt

* Digoxin
* Sensitiviti rabeprazole
* Ketaconazole
* Lactation
* Walfarin

* Ampicillin
* Hypersensitivity * Iron salt
* Lactation * Ketaconazole
*Walfarin

* Hypertension
* Urinary tract blockage
* Takikardia
* Liver disease
* Down sydrome
* Glaucoma
* Hypertension
* Urinary tract blockage
* Takikardia
* Liver disease
* Down sydrome
* Glaucoma

* Lactation

*anticoagulant
*hypersensitivity to macrolide *benzodiazepam
antibiobic *buspirone
*hepatic imparment *carbamezepine
*renal failure *colcicine
* acute porhyria *cyclosporine
* lactation *digoxin
*ergot alkaloids
*fluconazole
*theopylline
*verapamil

*allopurinol
* probenecid
*hypersensitivity to penicillin *MTX
*ACE Inhibitor
*Potassium sparing diuretic
*Potassium supplement
 *hypersensitivity *alcohol
*blood dyscrasias *anticoagulant
*1st semester pregnancy *disulfiram
*lactation *cimetidine
*phenytoin
*lithium

*antacid
*warfarin
*cimetidine
*ciprofloxacin
* renal impairment *digoxin
*diclofenac
*ketoconazole
*phenytoin
*theopyline
*tetracycline

* Chronical Renal Failures

* Pregnancy
* Pregnancy or Planning Pregnancy
* lactation