ABSTRAK..............................................................................................

iii
ABSTRACT............................................................................................iv
KATA PENGANTAR.............................................................................v
DAFTAR ISI...........................................................................................vii
DAFTAR GAMBAR..............................................................................ix
DAFTAR TABEL...................................................................................x
DAFTAR LAMPIRAN...........................................................................xi
BAB I PENDAHULUAN.......................................................................1
1.1 Latar belakang...................................................................................1
1.2 Identifikasi Masalah..........................................................................4
1.3 Tujuan Penelitian...............................................................................4
1.4 Kegunaan Penelitian..........................................................................4
BAB II TINJAUAN PUSTAKA.............................................................6
2.1 Artritis Reumatoid (AR)....................................................................6
2.1.1 Faktor Risiko Artritis Reumatoid...................................................6
2.1.2 Patofisiologis Artritis Reumatoid...................................................8
2.1.3 Kriteria Diagnosis Artritis Reumatoid...........................................10
2.1.4 Terapi Artritis Reumatoid..............................................................11
2.1.5 Metotreksat.....................................................................................14
2.2 Polimorfisme Gen yang Memengaruhi Respon Terapi MTX...........15
2.2.1 MTHFR A1298C dan C677T.........................................................16
BAB III METODE PENELITIAN..........................................................18
3.1 Rancangan Strategi Pencarian Kajian Pustaka..................................18
3.2 Kriteria Kajian Pustaka.....................................................................18
3.3 Tahapan Kajian Pustaka....................................................................20
3.4 Peta Kajian Pustaka...........................................................................21
BAB IV HASIL DAN PEMBAHASAN................................................23
4.1 Hasil Kajian Pustaka.........................................................................23
4.2 Pembahasan.......................................................................................26
4.2.1 Polimorfisme MTHFR C677T.......................................................26
4.2.2 Polimorfisme MTHFR A1298C.....................................................29
4.3 Luaran................................................................................................32
BAB V SIMPULAN DAN SARAN.......................................................48
5.1 Simpulan............................................................................................48
5.2 Saran..................................................................................................48
DAFTAR PUSTAKA.............................................................................50
LAMPIRAN 1.........................................................................................56
LAMPIRAN 2.........................................................................................57