No.

Kelompok 1 Kelompok 2 Kelompok 3 Kelompok 4

1. C0  konsentrasi saat t=0 Ln C0 (a) = 2,2871 Ln C0 (a) = 2,2362 C0
lnCo = 2,2805 C0 = 9,786 ppm C0 = 9,3577 ppm
Co = 0,824394717 9,786 ug/ml = 9,3577 ug/ml Ln C0 =
2,2465
C0 =
9,4545 ppm =
9,4545 ug/ml

2. K = 0,0041 menit-1 Ke= 0,003 Ke= 0,0043 Ke =0,003

3. T1/2 = 0,693/k t(1/2) = 0,693 / t(1/2) = 0,693 / t(1/2)

= 0,693/0,0041 Ke Ke
= 169,024 menit t(1/2) = 0,693 / t(1/2) = 0,693 / t(1/2) =
= jam 0,003 = 231 menit 0,0043 = 161,2 0,693 / Ke
= 3,85 jam menit = 2,68 jam t(1/2) =
0,693 /
0,003 =
231 menit
= 3,85
jam

4. Vd = dosis obat / Co D0 = Vd x C0 D0 = Vd x C0 D0
200mL = Do / D0 = 200 ml x D0 = 200 ml x
0,824394717 9,786 ug/ml = 9,3577 ug/ml = D0 = Vd x
Do = 200mL x 1.957,292 ug = 1871,54 ug = C0
0,824394717 µg/mL 1,957 mg 1,871 mg D0 = 200
Do = 164,87 µg ml x 9, 4545
Do = 0,16487 mg ug/ml
=
1890,9 ug =
1,8909 mg

5. Cl = Vd . k Cl = Ke x Vd Cl = Ke x Vd Klirens
= 0,2 L . Cl = 0,003 x 200 = Cl = 0,0043 x 200
0,0041 0,6 ml = 0,86 ml Cl = Ke x
= 0,00082 Vd
Cl = 0,003
x 200 ml =
0,6 ml

6. Nilai AUC AUC = D0/Cl AUC = D0/Cl AUC

Do AUC = 1,957 mg / AUC = 1,871 mg /
AUC = AUC =
Vd . k 0,6 ml = 3,261 0,86 ml = 2,175
AUC = mg/ml mg/ml D0/Cl
0 , 16487 mg AUC =
0,2 L . 0,0041menit−1 /menit 1,8909 mg / 0,6
AUC = 201,06 ml = 3,1515
 mg.menit/L mg/ml

Cpnya belum dimasukin

Cp0 kel 1 ??????

Cp0 kel 2

6. Waktu obat habis dalam plasma (Cp=0)

y = -0,003x + 2,2871

2,2871− y
x (t)=
0,003
2,2871−0
t=
0,003
2,2871
t=
0,003
t= 762,366 menit = 12,706 jam

Cp0 kel 3

6. Waktu obat habis dalam plasma (Cp=0)

y = -0,0043x + 2,2362

2,2362− y
x (t)=
0,0043
2,2362−0
t=
0,0043
2,2362
t=
0,0043
t= 520,05 menit = 8,6675 jam

Cp0 kel 4

Waktu obat habis dalam plasma (Cp=0)

y = -0,003x + 2,2465

2,2465− y
x (t)=
0,003
 2,2465−0
x (t)=
0,003
2,2465
=
0,003
= 748,83 menit = 12,480 jam
 Kurva Kalibrasi Parasetamol
0.9
0.8 f(x) = 0.08 x + 0.01
0.7 R² = 1 Kurva Kalibrasi
0.6 Parasetamol
0.5 Linear (Kurva
Kalibrasi
0.4 Parasetamol)
0.3
0.2
0.1
0
1 2 3 4 5 6 7 8 9 10 11

Hasil spektro 1a

t (menit) Absorbansi Konsentrasi In konsentrasi

(ppm)
10 0,795 9,356 2,236017849
20 0,767 9,021 2,199555193
30 0,734 8,633 2,155592069
40 0,711 8,366 2,124175873
50 0,672 7,906 2,067621965
60 0,649 7,630 2,032087845

No. Sampel Waktu Absorbansi

1 10 0.810
2 20 0.791
 3 30 0.735
4 40 0.732
5 50 0,726
6 60 0.747
2a

3a

No. Sampel Waktu Absorbansi

1 10 0.755
2 20 0.739
3 30 0.689
4 40 0.676
5 50 0,654
6 60 0.606

No. Sampel Waktu Absorbansi

1 10 0.755
2 20 0.739
3 30 0.689
4 40 0.676
5 50 0,654
6 60 0.606

No. Sampel Waktu Absorbansi

1 10 0.755
2 20 0.739
3 30 0.689
4 40 0.676
5 50 0,654
6 60 0.606
4a

waktu(menit) absorbansi
10 0,776
20 0,76
30 0,758
40 0,711
50 0,787
60 0,801