Diagnosis Anemia

Sherrie Perkins, MD, PhD in American Society for Clinical Pathol

Sherrie Perkins, MD, PhD in American Society for Clinical Pathol

Pemeriksaan Lab
KADAR HEMOGLOBIN
Normal : pria : 13 18 gr/dl
wanita : 12 16 gr/dl
JUMLAH SEL ERITROSIT
Normal : pria : 4,4 5,9 juta/cmm
wanita : 3,8 5,2 juta/cmm
HEMATOKRIT
- proporsi volume sel darah yang mengendap setelah
disentrifus dg kecepatan ttn dalam tabung Wintrobe
Normal : pria / wanita : 40 48% / 37-43%

Kapita Selekta Hematologi, 2013

MEAN CORPUSCULAR VOLUME (MCV)

volume rata-rata eritrosit
MCV =
Hct
x 10
Jumlah eritrosit (juta)

(fl)

Nilai normal : 80 94 fl

MEAN CORPUSCULAR HEMOGLOBIN (MCH)

kandungan Hb rata-rata eritrosit
MCH =
Hb
x 10
(pg)
Jumlah eritrosit (juta)
Nilai normal : 26 32 pg

Kapita Selekta Hematologi, 2013

MEAN CORPUSCULAR HEMOGLOBIN CONCENTRATION (MCHC)

kandungan hemoglobin rata-rata eritrosit
MCHC =
Hb
x 100 (gr/l)
Hct
Nilai normal : 30 36 g/l
RED CELL DISTRIBUTION WIDTH COEFFICIENT VARIATION
(RDW-CV)
pengukuran heterogenitas volume eritrosit yg didapat dari
histogram secara automatik
RDW-CV >>> : volume eritrosit bervariasi (anisositosis)
Nilai normal
: 11,5 14,5 %

Kapita Selekta Hematologi, 2013

RETICULOCYTE PRODUCTION INDEX (RPI)

* indeks produksi retikulosit
* RPI = retikulosit terkoreksi (%)
faktor koreksi
Retikulosit terkoreksi (%) = retikulosit (%) x Hct (pasien)
45

* RPI = 2, respons sum-sum tulang normal

* RPI < 2, respons sum-sum tulang inadekuat
* RPI > 2, respons sum-sum tulang meningkat &
sesuai dg derajat anemianya

Kapita Selekta Hematologi, 2013

KLASIFIKASI (Wintrobe)

b. Langkah awal mengklasifikasikan anemia secara morfologi

ANEMIA
MCV (fl)

MCV > 100

MCV < 80
MAKROSITIK
MIKROSITIK

MCV 80 100
NORMOSITIK

Kapita Selekta Hematologi, 2013

Sherrie Perkins, MD, PhD in American Society for Clinical Pathology

Sherrie Perkins, MD, PhD in American Society for Clinical Pathol

Sherrie Perkins,
MD, PhD in
American Society
for Clinical
Pathology

Sherrie Perkins, MD, PhD in American Society for Clinical Pathol