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PECTIN BASED COLON

TA R G E T E D D R U G D E L I V E R Y
SYSTEM

B Y : W I J D A N P R AT I W I
DA N I E L T I M OT I U S
GABRIELLA
LATAR BELAKANG
Drug delivery system adalah sistem yang mengatur proses
release dari obat pada jangka waktu yang ditentukan
yang terbentuk dalam material matriks padat dengan
partikel obat yang tersebar secara menyeluruh
didalamnya.

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LATAR BELAKANG
Pektin adalah polisakarida kompleks yang tersusun
atas residue asam (1-4)-D-galakturonat yang
teresterifikasi.

Dasar Pemilihan
Dapat bertahan lama pada G.I. tract
Dapat terdegradasi secara hamper sempurna oleh
bakteri-bakteri pada kolon
Non toxic
Biodegradable dan Biocompatible
Banyak sumbernya

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PERTIMBANGAN DASAR
Lokasi kolon yang jauh
Stabilitas dari obat
Mikroflora pada kolon
Pengembangan sistem

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PENGAMBILAN PEKTIN

Sub-critical Water Extraction

Acid Extraction

Enzyme Assisted Extraction (EAE) 4


PEMBUATAN HYDROGEL
pH diatur dengan
Pectin + CaCl + obat pH larutan dijaga 7,5 HCL sebesar 4,3 dan
diaduk hingga dengan penambahan larutan dididihkan
homogen NaOH dalam etanol 95%
selama 10 menit

Endapan yang
Endapan disimpan pada terbentuk dicuci
Larutan didinginkan
suhu -20 sebelum dengan etanol dan
pada suhu ruang
dianalisis aceton lalu dikeringkan
pada fume hood

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ANALISIS
In Vitro Release Study

Environmental Scanning Electron Microscope

Statistical Analysis

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APLIKASI
Bahan/Teknik Property Aplikasi Timescale
Nanoparticles dengan Partikel dengan ukuran yang Cancer treatment
rentang ukuran 50-100 lebih besar tidak bisa
nm. menembus pori tumor,
sementara yang nanoparticles
dapat dengan mudah menuju
tumor.

Nanosizing dengan Kelarutan yang rendah. More effective treatment


rentang ukuran 100-200 with existing drugs.
nm.
Polymers. These molecules can be Nanobiological drug carrying
engineered to a high degree devices.
of accuracy.
Ligands on a nanoparticle These molecules can be The ligand target receptors
suface. engineered to a high degree can recognise damaged
of accuracy. tissue, attach to it and release
a therapeutic drug.

Nanocapsules Evading bodys immune A Buckyball-based AIDS Early clinical.

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system whilst directing a treatment is just about to
therapeutic agent to the enter clinical trials.
desired site.
APLIKASI
Increased particle Degree of localised drug Slow drug release.
adhesion. retention increased.

Nanoporous materials. Evading bodys immune When coupled to sensors, Pre-clinical: an insulin
system whilst directing a drug delivering implants delivery system is being
therapeutic agent to the could be developed. tested in mice.
desired site.

Pharmacy-on-a-chip Monitor conditions and act E.g. diabetes treatment. More distant than lab-on-a-
as an artificial means of chip technologies.
regulating and maintaining
the bodys own hormonal
balance.

Sorting biomolecules. Nanopores and membranes Gene analysis and Current-?


are capable of sorting, for sequencing.
example, left-and right-
handed versions of
molecules.

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DAFTAR PUSTAKA
Adetunji, Lanrewaju Ridwan., Adekunle, ademola., Orsat, Valerie., Raghavan, Vijaya., 2016, Advances In The Pectin
Production Process Using Novel Extraction Techniques: A Review, Food Hydrocolloids.
Amritpal, S., Ankush, S., Pooja, Anju, 2014, Novel Approaches for Colon Targeted Drug Delivery System, Int. J. Res. Dev. Pharm.
L. Sci., 3, 877-886.
Azonano, 2004, Drug Delivery Systems-Markets and Applications for Nanotechnology Derived Drug Delivery
Systems.
Kavianinia, I., 2014. Polysaccharide hydrogels for colon-targeted drug delivery. Chemistry in New Zealand. 119-121.
May, Colin D., 1989, Industrial Pectins: Sources, Production and Aplication, H.P. Bulmer Pectin, Plough Lane, UK.
Meneguin, A. B., Cury, B.S.F., Evangelista, R. C., 2014, Film from resistant starch-pectin dispersions intended for colonic drug
delivery. Carb. Poly. 99. 140-149.
Rajpurohit, H., Sharma, P., Sharma, S., Bhandari, A.. 2010. Polymers for Colon Targeted Drug Delivery. Indian J. Pharm. Sci..
689-696.
Stephen, A. M., Phillips, G. O., Williams, P. A., 2006, Food Polysaccharides and Their Application. 2. 353-360.
Webster, J.G., 2016, Encyclopedia od Medical Devices and Instrumentation, Second Edition,, John Wiley and Sons, Inc.