TUGAS KELOMPOK 1,

PERJALANAN HEPATITIS B
MENJADI SIROSIS
 DIFEREN DIAGNOSIS HEPATITIS VIRUS

PENYAKIT DIAGNOSIS
TES SEROLOGI
HVA IgM anti HVA
HVB HBsAg, anti HBc
HVC Anti HVC
HVD Anti HVD
HVE Anti HVE
HVG Anti HVG
HVTT Anti HVTT
Autoimun Hepatitis ANA
AMA
Drug Induced Hepatitis Anamnesis
 HEPATITIS
Anti HVA (+) Anti HEV (+) Anti HBc (+) Anti HCV (+)
HBsAg (+)

HEP. B Akut
IgM Anti HVA (+)

Anti HVD (+)

HEPATITIS HEPATITIS C
HEPATITIS A HEPATITIS E B&D
 HEPATITIS KRONIS

• Penyebab VHB dan VHC

• Ikterus +/-
• SGOT, SGPT UP-Down tapi tidak mencapai nilai
normal
• Hepatomegali /splenomegali
• Bilirubin  albumin , CHE  protrombin time .
 HEPATITIS VIRUS B
STRUKTUR HEPATITIS B
HEPATITIS B KRONIS
Chronic Hepatitis B

Anti HBC

Anti HBC-IGM
 SEROLOGI HEPATITIS B
HBsAg Anti Anti HB anti Anti Interprestasi
HBs HBc Ag HBc
+ - IgM + - Hep. B Akut
+ - IgG + - Hep. B Kronis
+ - IgG - + Hep. B Kronis &
+ + + +/- +/- Infeksius
- - IgM +/- +/- Hep. B akan
- - IgG - +/- serokonversi
- + IgG - +/- Periode Jendela
- + - - - Karier Hep. B
Hep. B Akut & Infeksius
Sembuh / Post Vaksinasi
 PERJALANAN HEP. B KRONIK
SGOT ↑ 2 %/th SIROSIS
SGPT ↑ (+)

HVB
KANKER
KRONIK

SGOT N SIROSIS
SGPT N (-)
PENGOBATAN HEPATITIS B KRONIS

• LAMIVUDIN

• INTERFERON
SYARAT PEMBERIAN INTERFERON

• SGPT meningkat dan menetap

• HBsAg (+) 6 bulan
• HBeAg (+)
• HBV – DNA (+)
• HIV (-)