B1
C D
B3
B2
K
B6
B12 E
VITAMIN
Merupakan senyawa organik
Merupakan komponen dari bahan pakan
Terdapat dalam jumlah kecil
Esensial untuk pertumbuhan normal suatu
jaringan, kesehatan, pertumbuhan dan
pemeliharaan
Jika kekurangan menyebabkan gejala-gejala
spesifik
Beberapa pada ternak tertentu disintesa oleh
tubuh (sebagian besar tidak disintesa dalam
tubuh)
lanjutan
riboflavin
Pantotenat Sensitif hidrolisis
Niasin Hampirstabil
B12 Kestabilan tinggi, beberapa hilang bila
kedaluwarsa
Biotin Hampir stabil
Asamfolat Kestabilan sedang, sensitif oxidasi dan
reduksi
CH3 CH3
H3C CH3
OH
CH3
Retinol
b - Carotene and Retinol
CH 3
CH 3 CH 3 CH 3
H3 C
CH 3
CH 3 CH 3 CH 3
CH 3
Oxidation
CH 3 CH 3 O
H3 C CH 3
C H
CH 3 Retainal
- 2H
CH 3 CH 3
H3 C CH 3
CH 2 OH
CH 3 Retinol (Vitamin A)
Fungsi Vitamin A
1.Rangsangan cahaya dari mata ke otak
2.Berperan dalam sel epitel
3.Mengontrol aktivitas tulang
The vision cycle
Opsin balok : rodopsin
Opsin kerucut : iodopsin
Defisiensi Vitamin A
1.Buta malam
2.Seroptalamia (pengeringan & iritasi
kornea, keruh dan mudah terinfeksi)
3.Terganggu sel
Vitamin D
D2=Ergokalsiferol
D3=Kholekalsiferol
1. Kemunduran Reproduksi
2. Gangguan permeabilitas
3. Kerusakan otot
Vitamin K
K1 = Filoquinon
K2 = Menaquinon
K3 = Menadion
Fungsi Vitamin K
Koagulasi darah dengan mengaktifkan
prothrombin (sintesis prothrombin didalam
hati)
Thrombin Activation
vWF WOUND
collagen
endothelium
platelet
PL surface
Va
Ca Ca
Xa
Pro-Thrombin
Thrombin
S Gla Gla
Pro-
Gla Gla
SS
NH2
S COOH
proteolytic cut NH2
COOH C
i
r
c
ul
at
i
o
n
Vitamin B2
All these substances contain ribitol and a flavin or
isoalloxazine ring
Active forms are flavin mononucleotide (FMN)
and flavin adenine dinucleotide (FAD)
FMN is not a true nucleotide
FAD is not a dinucleotide
But the names are traditional and they persist!
Flavin Mechanisms
"Chemistry on a tether"
Biotin functions as a mobile carboxyl group
carrier
Bound covalently to a lysine
The biotin-lysine conjugate is called biocytin
The biotin ring system is thus tethered to the
protein by a long, flexible chain
Biotin Carboxylations
Most use bicarbonate and ATP
Whenever you see a carboxylation that requires
ATP and CO2 or HCO3-, think biotin!
Activation by ATP involves formation of carbonyl
phosphate (aka carboxyl phosphate)
Carboxyl group is transferred to biotin to form N-
carboxy-biotin
The "tether" allows the carboxyl group to be
shuttled from the carboxylase subunit to the
transcarboxylase subunit of ACC-carboxylase
Folic Acid
A Keratinisasi
Xeropthalmia
D Ricket
Osteomalacia
E Muscular distropy
Exudativediathesis
Encephalomalcia
K Terhambatnyaproses pembekuan
darah
GEJALA DEFISIENSI VITAMIN
VITAMIN GEJALA DEFISIENSI
pakan) Level
A 80.000 IU/kg 10
D3 10.000 IU/kg >60 d 3-4