kini menjadi pencipta barang keperluan sehari hari. Suatu hari, Larry berkunjung ke Museum tempat kerjanya dulu, dan menemukan bahwa teman temannya sudah masuk ke dalam kardus, siap dipindahkan ke museum di Washington D.C. Lalu, suatu malam, teman museumnya menelpon, bahwa mereka membutuhkan Larry, di rumah baru mereka tersebut. Ternyata karena pendapatan museum yang menurun, maka sebagian besar dari koleksi di museum tersebut akan dipindahkan ke museum di kota lain. Dan itu berarti nasib dari teman teman Larry menjadi tidak jelas. Larry bersama anaknya pun bertekad akan melakukan sesuatu untuk membantu mereka. Di museum baru yang lebih besar, Larry pun bertemu dengan lebih banyak lagi tokoh tokoh yang hidup, seperti Amelia Earhart (Amy Adams) si penerbang wanita pertama dari Amerika, juga Napoleon Bonaparte, Al Capone sampai raja raja Mesir yang berantem karena memperebutkan warisan leluhur mereka.
Larry Daly (Ben Stiller) who had left his old job as a museum guard, now a creator of consumer goods - day. One day, Larry visited his workplace Museum first, and found that ... friends - his friends had gone into the box, ready to be moved to a museum in Washington DC Then, one night, a friend of the museum called, that they need Larry, in their new home is. Apparently because the museum revenues decline, then most of the collections in the museum will be moved to the museum in another city. And that means the fate of friends - friends Larry became unclear. Larry with his son was determined to do something to help them. In the new and larger museum, Larry was met with even more characters - characters whose lives, like Amelia Earhart (Amy Adams) the first female pilot of the U.S., as well as Napoleon Bonaparte, Al Capone ... until the king - the king of Egypt are fighting for fighting their heritage
All passengers aboard Air Force One hostage, including the President's wife, Grace Marshall (Wendy Crewson) and their daughter, Alice (Liesel Matthews). But Mr Marshall managed to catch the terrorists escaped and hid in the vast planes. Although the escape was upset with the president, Egor immediately contacted the White House in Washington to demand the release of their leader, General Radek from prison. If not met, the terrorists would execute one passenger every half hour until their demands are met. While President Marshall suspected terrorists have escaped from the plane by using the lifeboats, secretly trying to take control of the plane. The terrorists who finally knows the business Marshall, tried to catch him alive. But they had underestimated the ability of the president, a former soldier the country's highest award-winning "Medal of Honor" on the battlefield of Vietnam. With still fit physique and martial arts skills, Marshall tried to finish off the terrorists one by one on the side trying to free his wife, his daughter and the other passengers. While tensions in the increasingly tense presidential plane, no less tense situation also faced by Vice President Kathryn Bennett (Glenn Close) who immediately held an emergency meeting to resolve the piracy. As per policy of the U.S. government, they should not even have to meet the demands of terrorists endanger their leader. While still confused Kathryn decision, he urged the Secretary of Defense Walter Dean (Dean Stockwell) to take over as the president may be considered permanently absent
technically. Vice-President is still in doubt despite requests Walter Dean also supported by the U.S. Attorney General (Philip Baker Hall).