DAFTAR ISI

Halaman
DAFTAR ISI..........................................................................................................i
DAFTAR TABEL ................................................................................................ii
DAFTAR GAMBAR ..........................................................................................iii
I. PENDAHULUAN.............................................................................................1
II. TINJAUAN PUSTAKA...................................................................................3
2.1. Thalasemia..............................................................................................3
2.1.1. Sejarah dan defenisi......................................................................3
2.1.2. Epidemiologi.................................................................................4
2.1.3. Klasifikasi Thalasemia..................................................................6
2.1.3.1. Sindrom Thalasemia-......................................................9
2.1.3.2. Hemoglobin Barts..........................................................10
2.1.3.3. Penyakit Hemoglobin H.................................................10
2.1.3.4. Sindrom Thalasemia- (Mayor) ....................................10
2.1.3.5. Sifat Thalasemia- (Minor) ...........................................11
2.1.3.6. Thalasemia Intermedia....................................................11
2.1.3.7. Thalasemia-.................................................................12
2.1.3.8. Hemoglobin Lepore........................................................12
2.2. Hemoglobin...........................................................................................12
2.2.1. Sintesis Hemoglobin...................................................................12
2.2.2. Aspek Molekular Globin.............................................................13
2.2.3. Peralihan dari Hemoglobin Janin ke Hemoglobin Dewasa.........15
2.3. Thalasemia Mayor..............................................................................15
2.3.1. Patofisiologi Thalasemia Mayor..............................................16
2.3.2. Gambaran Klinis.........................................................................19
2.3.3. Diagnosis Laboratorium..............................................................21
2.3.4. Penilaian Status besi....................................................................21
2.3.5. Pengobatan..................................................................................22
2.3.6. Pencegahan..................................................................................24
III. KESIMPULAN.............................................................................................26
DAFTAR PUSTAKA..........................................................................................27