DAFTAR ISI

HALAMAN JUDUL...........................................................................................
i
HALAMAN PENGESAHAN.............................................................................
ii
DAFTAR ISI........................................................................................................
iii
DAFTAR TABEL................................................................................................
iv
DAFTAR GAMBAR...........................................................................................
v
DAFTAR LAMPIRAN........................................................................................
vi
BAB I PENDAHULUAN....................................................................................
1
1.1

Latar Belakang................................................................................
1

1.2

Rumusan Masalah...........................................................................
2

1.3

Tujuan Penelitian............................................................................
2
1.3.1

Tujuan Umum.....................................................................

2
1.3.2

Tujuan Khusus....................................................................

3
1.4

Hipotesis.........................................................................................
3

1.5

Manfaat Penelitian..........................................................................
3
iii

BAB II TINJAUAN PUSTAKA..........................................................................

5
2.1

Jantung............................................................................................

5
2.1.1

Anatomi jantung..................................................................

2.1.2

Histologi jantung.................................................................

2.1.3

Fisiologi jantung.................................................................

5
7
9
2.2

Sindroma Koroner akut...................................................................

12
2.2.1

Definisi................................................................................

2.2.2

Epidemiologi.......................................................................

2.2.3

Patofisiologi........................................................................

2.2.4

Etiologi................................................................................

2.2.5

Faktor Risiko.......................................................................

2.2.6

Diagnosis.............................................................................

2.2.7

Klasifikasi...........................................................................

2.2.8

Tatalaksana..........................................................................

12
12
13
15
17
17
18
19
2.3

Cardiac Biomarker..........................................................................

20

iv

2.3.1

Definisi................................................................................

2.3.2

Jenis Biomarker jantung.....................................................

2.3.3

Fisiologi enzim kardiovaskular...........................................

2.3.4

Referensi nilai.....................................................................

20
21
22
23
2.4

Kerangka Teori................................................................................

24
BAB III METODE PENELITIAN......................................................................
25
3.1

Jenis Penelitian................................................................................

3.2

Lokasi dan Waktu Penelitian...........................................................

3.3

Populasi dan Sampel Penelitian......................................................

25
25
25
3.3.1

Populasi Penelitian..............................................................

3.3.2

Sampel Penelitian................................................................

25
25
3.3.2.1

Besar Sampel.......................................................

3.3.2.2

Cara Pengambilan Sampel...................................

25
26
3.3.3

Kriteria Inklusi dan Eksklusi..............................................

26
3.3.3.1

Kriteria Inklusi.....................................................

26

3.3.3.2

Kriteria Eksklusi..................................................

26
3.4

Variabel Penelitian..........................................................................

26
3.4.1

Variabel bebas.....................................................................

3.4.2

variabel terikat....................................................................

26
26
3.5

Definisi Operasional.......................................................................

26
3.5.1

Pasien STEMI.....................................................................

3.5.2

Pasien NSTEMI..................................................................

3.5.3

Troponin T..........................................................................

3.5.4

CK-MB ..............................................................................

3.5.5

CK-NAC.............................................................................

26
27
27
27
28
3.6

Cara Pengumpulan Data.................................................................

3.7

Rencana Cara Pengolahan dan Analisis Data.................................

3.8

Kerangka Operasional.....................................................................

3.8

Rencana Kegiatan...........................................................................

3.9

Anggaran Dana...............................................................................

28
28
29
30
30

vi

BAB IV JUSTIFIKASI ETIK..............................................................................

31
4.1

Rangkuman Karakteristik Penelitian..............................................

4.2

31
Kelayakan Etik................................................................................
31

DAFTAR PUSTAKA...........................................................................................
32
BIODATA ............................................................................................................
33

vii

DAFTAR TABEL
Tabel 2.1

Hasil nilai Cardiac Biomarker pada MI..........................................

13

viii

DAFTAR GAMBAR
Tabel 2.1

Anatomi katup jantung....................................................................

5
Tabel 2.2

Topografi anatomi jantung di dalam rongga dada..........................

6
Tabel 2.3

Histologi jantung.............................................................................

8
Tabel 2.4

Fisiologi jantung.............................................................................

10
Tabel 2.5

Sirkulasi koroner pada jantung.......................................................

11
Tabel 2.6

Kelainan segmen ST-T pada SKA..................................................

18

ix