Kurva eliminasi

Y = - 0.075x + 1.233
Eliminasi orde 1
Slope = Ke/ 2.303
0.075 =ke/ 2.303
Ke = 0.075X 2.303
Ke = 0.173/jam
Interceps = log B
1.233 = log B
B = antilog 1.233
B = 17.100 g/ml

Kurva absorpsi
Y= - 0.331 + 1.234
Obat biasa orde 1
Slope = ka/2.303
0.331 = ka/2.303
Ka = 0.331 X 2.303
Ka = 0.762 / jam
Interceps = log A
1.234 = antilog a
A = 17.140 g/ml

Tmax = Ln (ka/k) / ka-k

Tmax = Ln ( 0.762/0.173) / 0.762-0.173
Tmax = 2.517 jam

CpMax = BeKtMax AekatMax

CpMax = 17.100e-0.173 X 2.517 17.140 e- 0.762 X 2.517
CpMax = 17.100e-0.435 17.140 e-1.918
CpMAx = 17.100 X 0.647 17.140 X 0.147
CpMax = 11.064 2.520
Cp Max = 8.544 g/ml

T = 0.693 / ke
T = 0.693/0.173 = 4.006 / jam

AUC0-inf = B/K A/ka

AUC0-inf = 17.100/0.173 17.140/0.762
AUC0-inf = 98.844 22.493
AUC0-inf = 76.531 g jam/ml

VD = FD0 / (k AUC0-inf )
VD = 0.8 X 500 / 0.173 X 76.531
VD = 400 / 13.240 = 30.211 ml

ClT = K X VD
ClT = 0.173 X 30.211 = 5.227ml/jam