ABSTRAK

Helmi, Festi. Mada.2018, “Efek Ekstrak Umbi Rumput Teki (Cyperus Rotundus L.) terhadap
Kadar HDL Tikus Putih (Rattus novergicus) Jantan strain wistar Model
Hiperlipidemi”. Tugas Akhir Fakultas Kedokteran, Universitas Muhammadiyah
Malang. Pembimbing(I) Sulistyo Mulyo Agustini* (II) Thontowi Djauhari**.

Latar Belakang: HDL (High Density Lippoprotein) digunakan sebagai parameter

hiperlipidemi, ditandai dengan kadar HDL yang rendah. Umbi rumput teki (Cyperus
Rotundus L.) memiliki zat aktif yaitu sitosterol yang berfungsi sebagai antioksidan dengan
mekanisme kerja meningkatkan HDL.
Tujuan: Mengetahui pengaruh pemberian ekstrak umbi rumput teki (Cyperus Rotundus L.)
terhadap kadar HDL tikus putih (Rattus novergicus strain wistar) model hiperlipidemi.
Metode: True Eksperimental, Post Test Only Control Group Design. Sampel dibagi 5
kelompok. Kelompok 1 (Kontrol negatif), kelompok 2 (Kontrol positif) diberi induksi diet
hiperlipidemi, dan kelompok 3 kelompok diberi ekstrak umbi rumput teki (Cyperus Rotundus
L.) dosis 125 mg/kgBB/hari, 250 mg/kgBB/hari, 500 mg/kgBB/hari selama 28 hari.
Hasil penelitian dan diskusi: Uji One Way ANOVA didapatkan nilai p signifikan (<0,05)
dengan r sebesar 0,000 yang berarti terdapat pengaruh bermakna antara pemberian ekstrak
dengan peningkatan kadar HDL tikus putih jantan model hiperlipidemi. Uji regresi
menunjukkan besarnya pengaruh antar kelompok perlakuan sebesar 51%. Berdasarkan hasil
uji yang dilakukan menunjukkan semakin tinggi dosis ekstrak yang diberikan, semakin tinggi
kadar HDL tikus.
Kesimpulan: Terdapat Pengaruh Pemberian Ekstrak umbi Rumput Teki (Cyperus Rotundus
L.) terhadap kadar HDL tikus putih jantan model Hiperlipidemi dengan dosis efektif 125
mg/kgBB dan dosis optimal 500 mg/kgBB.

Kata Kunci :Umbi rumput teki, Sitosterol, dan HDL

* Staf Pengajar Patologi Klinik Fakultas Kedokteran Universitas Muhammadiyah Malang.

** Staf Pengajar Anatomi Fakultas Kedokteran Universitas Muhammadiyah Malang.

 ABSTRACT

Helmi, Festi Mada. 2018, “The effectiveness of Extract Cyperus Rotundus Rhizomes
(Cyperus Rotundus L.) towards the HDL level in Male Rat Strain Wistar (Rattus
novergicus) in Hyperlipidemic Model ". Thesis of Medical Faculty, University of
Muhammadiyah Malang.
Advisors: (I) Sulistyo Mulyo Agustini*, (II) Thontowi Djauhari**.

Backgrounds: HDL (High Density Lippoprotein) is used as a hyperlipidemic parameter, by

low HDL.Cyperus rotundus rhizomes (Cyperus Rotundus L.) has an active substance
sitosterol as an antioxidant by increasing the HDL.
Objective: Finding out the effectiveness of Extract Cyperus rotundus rhizomes (Cyperus
Rotundus L.) towards the HDL level in male rat strain wistar (Rattus novergicus) in
Hyperlipidemic Model.
Methods: True Experimental, Post Test Only Control Group Design. Sample divided by 5
groups. Group 1 (negative control), group 2 (positive control) were inducted by
hyperlipidemic diet and 3 groups were given extract of Cyperus rotundus rhizomes (Cyperus
Rotundus L.) with dose: 125 mg/kgBB/day, 250 mg/kgBB/day, 500mg/kgBB/day for 28
days.
Result: One Way of ANOVA test resulted in significant p value (<0,05) with r equal to
0,000 which meant there was a significant influence between giving the extract of Cyperus
rotundus rhizomes with the increase of HDL level in white male rat in hiperlipidemic model.
Regression test showed that the influence between treatment groups was 51%. Based on the
results of the test it showed that the higher dose of the extract, the higher levels of HDL’s rat.
Conclusion: There was an Effect of the Extract of Cyperus Rotundus Rhizomes (Cyperus
Rotundus L.) towards the HDL level in male rat strain wistar (Rattus novergicus) in
Hyperlipidemic Model with the effective dose 125 mg/kgBB and the optimal dose 500
mg/kgBB.
Keyword:The extract of Cyperus rotundus rhizomes, Sitosterol, and HDL.

*Lecturer of Clinical Pathology, Medical Faculty, University of Muhammadiyah Malang.

** Lecturerof Anatomy Department, Medical Faculty, University of Muhammadiyah Malang.