ppm absorbansi

0.8
2 0.279 0.7
f(x) = 0.0451571429x + 0.1810666667
4 0.372 0.6 R² = 0.9922898969
0.5
6 0.428
0.4
8 0.531 0.3 Linear
10 0.648 0.2
0.1
12 0.725
0
lar. Induk 200 ppm 4.683 0 2 4 6 8 10 12 14

Waktu Absorbansi c (ppm) Bobot terdisolusi (mg) Faktor koreksi

4 0.087 10.40 10.40 0.00
5 0.726 19.30 19.30 0.10
7 1.752 27.30 27.30 0.14
10 40.60 40.60 0.20
15 70.30 70.30 0.35
30 0.209 89.30 89.30 0.45
45 0.233 91.80 91.80 0.46

mg terdisolusi= (ppm x media disolusi

(ml))/(1000 ml)

faktor koreksi= (ppm x sampling

(ml))/(1000 ml)
 lamda mx = 260 nm
I tablet paracetamol = 500mg/500ml =
71429x + 0.1810666667
8969 tablet yg dipake = 1 tablet =

Linear () ppm = mikrog/ml

vol media 1L
8 10 12 14 j sediaan 100 mg
vol cuplikan 5 ml
Bobot terdisolusi yang terkoreksi ( mg ) % terdisolusi
10.40 10.40
19.30 19.30
27.40 27.40
40.83 40.83
70.74 70.74
90.09 90.09
93.03 93.03

% disolusi= (mg koreksi)/

(mg zat sampel)

koreksi= (ppm x sampling

(1000 ml)

mg terdisolusi setelah dikoreksi= mg terdisolusi + faktor koreksi sebelum2nya

data reference %terdisol
time point 1 2 3 rata-rata
3 18.7 19.25 18.57 18.84
5 39.7 40.25 39.57 39.84
7 57.9 58.45 57.77 58.04
10 75.89 76.44 75.76 76.03
15 86.39 86.94 86.26 86.53
30 89.39 89.94 89.26 89.53
45 91.89 92.44 91.76 92.03

data test
time point 1 2 3 rata-rata Rt-Tt
3 16.7 17.25 16.57 16.84 2
5 37.7 38.25 37.57 37.84 2
7 55.9 56.45 55.77 56.04 2
10 73.89 74.44 73.76 74.03 2
15 84.39 84.94 84.26 84.53 2
30 87.39 87.94 87.26 87.53 2
45 89.89 90.44 89.76 90.03 2
Ʃ(Rt-Tt)^2
n (jumlah sampel)=3 1/n
(1/n)*Ʃ(Rt-Tt)^2
1+(1/n)Ʃ(Rt-Tt)^2
[1+(1/n)Ʃ(Rt-Tt)^2]^-0.5
100*[1+(1/n)Ʃ(Rt-Tt)^2]^-0.5
log{[1+(1/n)Ʃ(Rt-Tt)^2]^-0.5x100}
f2 (f kesamaan) 50*log{[1+(1/n)Ʃ(Rt-Tt)^2]^-0.5x100}
 diabsolutkan biar ga negatif
(Rt-Tt)^2 ǀRt-Ttǀ n*ǀRt-Ttǀ n*rata2 Rt
4 2 6 56.52
4 2 6 119.52
4 2 6 174.12
4 2 6 228.09
4 2 6 259.59
4 2 6 268.59
4 2 6 276.09
28 Ʃ(nǀRt-Ttǀ) 42 Ʃn*rata2 Rt 1382.52
0.3333333333 Ʃ(nǀRt-Ttǀ)/ƩnRt 0.0303793074
9.3333333333 f1 (f perbedaan) 100*{[Ʃ(nǀRt-Ttǀ)]/[ƩnRt]} 3.0379307352
10.3333333333
0.3110855084 Kesimpulan: produk tes similar dengan patennya
31.1085508419
1.4928797804
74.6439890221 ket: jika F2 50-100 dan jika F1 0-15 → similar atau ekivalen (sama sec
imilar atau ekivalen (sama secara BA)