ABSTRAK

Kho Chah, G0014252, 2017. Pengaruh Pemberian Ekstrak Kayu Manis

(Cinnamomum burmannii) terhadap Penurunan Kadar Gula Darah Tikus Putih yang
Diinduksi Aloksan. Skripsi. Fakultas Kedokteran Universitas Sebelas Maret
Surakarta.

Latar belakang: Kayu manis (Cinnamomum burmannii) merupakan obat herbal yang
banyak beredar di masyarakat karena dianggap mampu menurunkan kadar gula darah.
Kayu manis mengandung sinamal aldehid, eugerol, flavonoid, alkaloid, phenolic, asam
sinamat, katekin, epikatekin dan polifenol yang berperan dalam penurunan gula darah.
Pada penelitian ini bertujuan untuk membuktikan bahwa pemberian berbagai dosis
ekstrak kayu manis berpengaruh terhadap penurunan kadar gula darah tikus putih
(Strain Sprague dawley) yang diinduksi aloksan.

Metode Penelitian: Penelitian ini menggunakan metode eksperimental laboratorium

dengan rancangan penelitian pre test and post test control group design. Sampel terdiri
dari 30 ekor tikus putih (Strain Sprague dawley), berusia ±3 bulan dengan berat bedan
± 200 gram. Sampel dibagi menjadi 5 kelompok, yaitu: Kelompok kontrol negatif (1);
Kelompok kontrol positif (2); Kelompok ekstrak kayu manis dosis I (3); Kelompok
ekstrak kayu manis dosis II (4); Kelompok kayu manis dosis III (5) . Kelima kelompok
tersebut setelah diadaptasi selama 7 hari, kemudian diinsuksi aloksan 150 mg/KgBB
agar menjadi DM, lalu diukur kadar gula darah sebagai pre test. Setelah itu kelompok
1 diberi aquadest dan pakan. Kelompok 2 diberi metformin dan pakan selama
penelitian berlangsung. Kelompok 3, 4, dan 5 diberi pakan standar dan ekstrak kayu
manis dengan berbagai dosis (200 mg/KgBB, 400 mg/KgBB dan 600 mg/KgBB)
selama 14 hari, kemudian diukur kadar gula darahnya lagi sebagai post test. Data
kemudian diuji dengan menggunakan One Way Anova dan Uji Paired Sample T Test.

Hasil Penelitian: Terdapat penurunan kadar gula darah pada kelompok 2, 3, 4 dan 5.
Kelompok 1 mengalami peningkatan kadar gula darah. hasil analisis statistik
menunjukkan perbedaan yang bermakna dimana p = 0.000 dengan taraf signifikansi
sebesar 0,05.

Simpulan Penelitian: Pemberian berbagai dosis ekstrak kayu manis (Cinnamomum

burmannii) berpengaruh terhadap penurunan kadar gula darah tikus putih (Strain
Sprague dawley) yang diinduksi aloksan.
 ABSTRACT

Kho Chah, G0014252, 2017. The Effect of Cinamon Extract (Cinnamomum

burmannii) in Decreasing of Blood Glucose Level of Aloxan Induced White Rats
(Strain Sprague dawley). Mini Thesis. Sebelas Maret University Surakarta Faculty of
Medicine.

Background: Cinnamon (Cinnamomum burmannii) was herbal medine that widely

uesed by today society. It was believed able to deccrease blood glucose levels.
Cinnamon were containing sinamal aldehid, eugerol, flavonoid, alkaloid, phenolic,
asam sinamat, katekin, epikatekin dan polifenol, that having a roles on decreasing
blood glucose levels. The purpose of this research were to prove that multiple dose of
cinnamon extract able to descrease blood glucose levels on aloxan induced white rats.

Methods: This was a laboratory experimental research with pre test and post test
control group design. Samples were consisted of 30 white rats (Strain Sprague dawley)
aged ± 3 months old, weight ± 200 grams. Samples were divided into 5 different
groups, Group 1 was negative control, Group 2 was positive control, Group 3 was given
I dose of cinnamon extract, Group 4 was given II dose of cinnamon extract, Group 5
was given III dose of cinnamon extract. All groups then induced by 150 mg/Kg weight
aloxan to make them diabetic. The blood glucose levels were measured after wards as
pre test. Group 1 were treated with aquadest standard pellet. Group 2 were treated with
merformin and standard pellet. Gorup 3,4 and 5 were treated with multiple doses of
cinnamon extract (200, 400 dan 600 mg/Kg weight) on 14 days long and the blood
glucose levels were then measured as post test. The data were analyzed with One Way
Anova and Paired t Test.

Results: The blood glucose level were decreased in group 2, 3, 4, and 5 while in the
other hand increased in group 1. The statistic analysis was showing a signifikant
differences where p = 0.000 with significancy level 0.05.

Conclusion: The administration of multiple doses cinnamon extract (Cinnamomum

burmannii) was able to decrease blood glucose levels on aloxan induced white rats.