HALAMAN PENGESAHAN

FORMULASI DAN UJI AKTIVITAS PASTA

GIGI ARANG AKTIF CANGKANG SAWIT
(Elaeis guineensis) SEBAGAI
ANTIPLAK SECARA INVITRO

Oleh:
NURUL RIZQAN SEPTIMA
F1F115021

Disetujui :

Pembimbing Utama Pembimbing Pendamping

Dr. Drs. Syamsurizal,. M.Si. Uce Lestari, S.Farm.,M.Farm.Apt

NIP. 196809181993031003 NIK. 201501072017

Diketahui:

Ketua Program Studi Farmasi

Fakultas Sains dan Teknologi
Universitas Jambi

Elisma, S.Farm, M.Farm., Apt.

NIP. 198510212014042001

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 DAFTAR ISI

Halaman

HALAMAN PENGESAHAN ............................................................................ i

DAFTAR ISI ................................................................................................. ii

DAFTAR TABEL .......................................................................................... iii

DAFTAR GAMBAR ....................................................................................... iv

DAFTAR LAMPIRAN .................................................................................... v

I. PENDAHULUAN ............................................................................... 1
1.1 Latar Belakang ........................................................................... 1
1.2 Identifikasi dan Rumusan Masalah ............................................. 2
1.3 Tujuan Penelitian ...................................................................... 2
14 Manfaat Penelitian ...................................................................... 2
II. TINJAUAN PUSTAKA ........................................................................ 3
2.1 Kelapa Sawit (Elaeis guineensis Jacq). ......................................... 3
2.2 Arang Aktif ................................................................................. 4
2.3 Gigi ............................................................................................ 5
2.4 Dampak merokok terhadap gigi .................................................. 6
2.5 Plak ........................................................................................... 6
2.6 Pasta gigi ................................................................................... 7
2.7 Jenis sediaan pasta gigi .............................................................. 9
2.8 Efektivitas Antiplak .................................................................... 9
2.9 Evaluasi Pasta gigi ..................................................................... 10
III. METODOLOGI PENELITIAN.............................................................. 12
3.1 Tempat dan Waktu ..................................................................... 12
3.2 Alat dan Bahan .......................................................................... 12
3.3 Rancangan Percobaan ................................................................ 12
3.4 Metode Penelitian ....................................................................... 13
IV. HASIL DAN PEMBAHASAN ............................................................... 17
4.1 Uji Kualitatif Terhadap Metilen Biru………………………..…………. 17
4.2 Uji Kuantitatif terhadap iodine .................................................... 17
4.3 Formulasi sediaan pasta gigi arang aktif ..................................... 18
4.4 Evaluasi Sifat Fisik Sediaan Pasta Gigi ....................................... 19
4.5 Uji Iritasi Sediaan Pasta Gigi ...................................................... 30
4.6 Uji Efektivitas Sediaan Pasta Gigi ............................................... 31

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 V. PENUTUP......................................................................................... 32
5.1 Kesimpulan ................................................................................ 32
5.1 Saran ......................................................................................... 32
DAFTAR PUSTAKA ...................................................................................... 33
LAMPIRAN .................................................................................................. 36

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 DAFTAR TABEL

Tabel Halaman
1. Formula Pasta Gigi ....................................................................... 16
2. Uji Organoleptis Pasta Gigi ............................................................ 19
3. Hasil Homogenitas Pasta Gigi ........................................................ 20
4. Hasil pH Pasta Gigi ....................................................................... 20
5. Hasil daya sebar pasta Gigi ........................................................... 22
6. Hasil Tinggi Busa Pasta Gigi ......................................................... 22
7. Hasil Viskositas Pasta Gigi ............................................................ 23
8. Organoleptis Cycling test Pasta Gigi .............................................. 25
9. pH Cycling test Pasta Gigi ............................................................ 26
10.daya sebar Cycling test Pasta Gigi ................................................ 27
12. Tinggi busa Cycling test Pasta Gigi .............................................. 28
13. Rekapitulasi Evaluasi Pasta Gigi ................................................. 28
14. Hasil Uji Iritasi Pasta Gigi ........................................................... 30
15. Hasil Uji Antiplak Pasta Gigi ....................................................... 31

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 DAFTAR GAMBAR

Gambar Halaman
1. Cangkang Kelapa Sawit ................................................................ 4
2. Struktur gigi ................................................................................. 6
3. Bagan Alir Penelitian .................................................................... 36

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 DAFTAR LAMPIRAN

Lampiran Halaman
1. Bagan Alir Penelitian ................................................................. 36
2. Bagan alir uji efektivitas antiplak ............................................... 37
3. Data Uji pH pasta gigi ................................................................ 38
4. Data Uji Daya Sebar sediaan pasta gigi ...................................... 39
5. Hasil Determinasi Slug .............................................................. 40
6. Penentuan daya serap arang aktif dengan iodine ........................ 41
7. Uji Iritasi Menggunakan Slug ..................................................... 42
8. Data Statistik Uji pH pasta gigi .................................................. 43
9. Data Statistik daya sebar pasta gigi ........................................... 44
10. Data Statistik tinggi busa pasta gigi ......................................... 45
11. Data Statistik viskositas pasta gigi ........................................... 46
12. Data Statistik Uji stabilitas pH pasta gigi ................................. 47
13. Data Statistik Uji stabilitas daya sebar pasta gigi ..................... 48
14. Data Statistik Uji stabilitas tinggi busa pasta gigi ..................... 49
15. Data Statistik Uji iritasi pasta gigi ............................................ 50
16. Data Statistik Uji efektivitas stabilitas pH pasta gigi ................. 51
17. Data Statistik Uji stabilitas pH pasta gigi ................................. 52
18. Hasil Viskositas Formula 1 replikasi 1 ..................................... 53
19. Hasil Viskositas Formula 1 replikasi 2 ..................................... 54
20. Hasil Viskositas Formula 1 replikasi 3 ..................................... 55
21. Hasil Viskositas Formula 2 replikasi 1 ..................................... 56
22. Hasil Viskositas Formula 2 replikasi 2 ..................................... 57
23. Hasil Viskositas Formula 2 replikasi 3 ..................................... 58
24. Hasil Viskositas Formula 3 replikasi 1 ..................................... 59
25. Hasil Viskositas Formula 3 replikasi 2 ..................................... 60
26. Hasil Viskositas Formula 3 replikasi 3 ..................................... 61
27. Hasil Viskositas Formula 4 replikasi 1 ..................................... 62
28. Hasil Viskositas Formula 4 replikasi 2 ..................................... 63
29. Hasil Viskositas Formula 4 replikasi 3 ..................................... 64

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