kadar absorbansi kadar recovery % recovery

20 0 -112.836538462 -564.18269
50 0.062 -106.875 -213.75
100 0.898 -26.4903846154 -26.490385
150 -0.005 -113.317307692 -75.544872
200 0 -112.836538462 #NAME?
rata-rata #NAME?
Kadar Absorbansi Absorbansi
20 1 4
50 2 f(x) = 0.010397467166979 x + 1.17346341463415
3
100 2 R² = 0.947753481660145
150 3 3

200 3 2

0
0 50 100 150 200 2

III. Penetapan kadar salisilat dalam sampe

kadar absorbansi kadar recovery % recovery No. waktu (menit)
20 0 -112.83653846154 -564.182692
50 0.062 -106.875 -213.75
100 0.898 -26.490384615385 -26.4903846
150 -0.005 -113.31730769231 -75.5448718
200 0 -112.83653846154 -56.4182692
rata-rata -187.277244
bansi

150 200 250

III. Penetapan kadar salisilat dalam sampel dan penetapan parameter farmakokinetika dengan metode sigma minus
Volume urine (ml) Absorbansi Kadar Salisilat (ppm) kadar salisilat dalam (mg) urine (Xu) ƩXu
minus
Xu˷-Xu
 III. Penetapan kadar salisilat dalam sampel dan penetapan parameter farmakokinetika dengan me
No. waktu (menit) Volume urine (ml) Absorbansi Kadar Salisilat (ppm)
1 0 14 0.079 -105.24
2 15 25 0.079 -105.24
6 120 60 3.728 245.63
7 150 90 3.308 205.24
8 180 120 3.224 197.16
9 240 160 3.299 204.38
10 300 190 3.368 211.01
11 420 250 3.290 203.51
12 540 230 3.257 200.34
13 660 220 3.341 208.41
14 780 260 3.287 203.22
15 1020 200 3.152 190.24
16 1260 150 3.217 196.49
17 1440 100 3.220 196.78
18 1500 125 2.230 101.59

waktu (menit) ln(ƩXu˷-Xu

0 6.21
15 6.21 Kurva Farmakokinetika
120 6.18 7.00
150 6.15
180 6.09 6.00 f(x) = − 0.001303612936166 x + 6.29024410496191
R² = 0.993932403247484
240 6.02 5.00
300 5.91
420 5.77 4.00
540 5.61
3.00
660 5.43
780 5.16 2.00
1020 4.92
1.00
1260 4.67
1440 4.47 0.00
0 200 400 600 800 1000 1200 1
1500 4.31
an parameter farmakokinetika dengan metode sigma minus
kadar salisilat dalam (mg) urine (Xu) ƩXu ƩXu˷-Xu ln(ƩXu˷-Xu
- - 500.00 6.21
- - 500.00 6.21
14.74 14.74 485.26 6.18
18.47 33.21 466.79 6.15
23.66 56.87 443.13 6.09
32.70 89.57 410.43 6.02
40.09 129.66 370.34 5.91
50.88 180.54 319.46 5.77
46.08 226.62 273.38 5.61
45.85 272.47 227.53 5.43
52.84 325.30 174.70 5.16
38.05 363.35 136.65 4.92
29.47 392.83 107.17 4.67
19.68 412.50 87.50 4.47
12.70 425.20 74.80 4.31
ƩXu˷ 500.00 -

urva Farmakokinetika

x + 6.29024410496191

600 800 1000 1200 1400 1600

 penentuan konstanta eliminasi
waktu ln(ƩXu˷-Xu
780 5.16 Kurva Konstanta Eliminasi
1,020 4.92 5.2
1,260 4.67 5.1 f(x) = − 0.001020833333333 x + 5.95791666666667
R² = 0.999861188228762
5

4.9

4.8

4.7

4.6

4.5

4.4
700 800 900 1,000 1,100 1,200

waktu Ʃ(Xu˷-Xu) extrapolasi residu ln residu waktu ln residu

120 485.26 436.11 49.15 3.89 120 3.89
150 466.79 449.39 17.40 2.86 150 2.86 4.50
180 443.13 463.08 19.95 2.99 180 2.99 4.00
3.50 f(x) =
R² = 0
3.00
2.50
2.00
1.50
1.00
0.50
0.00
110 120
Eliminasi

66666667

1,100 1,200 1,300

konstanta absorbsi
4.50
4.00
3.50 f(x) = − 0.015 x + 5.49666666666667
R² = 0.643606314228202
3.00
2.50
2.00
1.50
1.00
0.50
0.00
110 120 130 140 150 160 170 180 190