05 Jaundice
05 Jaundice
Bile
Transportase dari bilirubin
Klasifikasi
Klasifikasi jaundice menurut :
1. Unconjugated hyperbilirubinemia
2. Conjugated hyperbilirubinemia
1. Unconjugated hyperbilirubinemia
Overproduction from breakdown of haemoglobin and
other heme proteins
Haemolysis (intra-and extravascular)
Ineffective erythropoiesis
Enhanced turnover of hepatic heme enzymes
Impairment of hepatic uptake
Decreased delivery to the liver
Drugs
Gilbert syndrome,type I
Impairment of hepatic conjugation
Neonatal
Maternal milk
Lucey-Driscoll syndrome
Crigler – Najjar syndrome, type I
Crigler – Najjar syndrome, type II (arias syndrome)
Gilbert syndrome, type II
Drugs
Conjugated hyperbilirubinemia
Defect of hepatic exretion
Extrahepatic bile duct obstruction
Extrahepatic bile duct atresia
Hepatic jaundice
Intrahepatic reversible cholestatis
familial recurrent cholestatis ( Summerskill -
Walshe syndrome)
Recurrent cholestatis of pregnancy
Intrahepatic progressive cholestatis
Infancy progressive cholestatis (Byler syndrome)
Arteriohepatic dysplasia (Alagille syndrome)
Primary biliary cirrhosis
Primary sclerosing cholangitis (PSC)
Inherited defective excretio of conjugated organic
anions and coproporphyrin
Dubin – johnson syndrome
Rotor syndrome
Beberapa penyebab jaundice yg sering dgn investigasinya
Penyebab Investigasi
Acute hepatitis - HBsAg, anti – HBc IgM, HBeAg, anti-Hbe
- Anti-HAV IGM, Anti delta antibody
- Anti HCV
- Anti HEV ?
- IgM-EBV, IGM-CMV, Leptospiral antibody
Pancreatic / Biliary - Ultrasonography
Disease - Endoscopic retrograde cholangiography- c
Pancreatography
- Percutaneuos transhepatic cholangiography
- CT scan
Malignancy - Ultrasonography
- CT scanning
- Liver biopsy
- Alpha foetoprotein
Cirrhosis - Hepatitis B/C serology
- Ultrasonography
- Liver biopsy
- Immunoglobulins
- Auto antibodies
- Iron studies
- serum, urine and liver copper;serum
ceruloplasmin
- alpha 1 antitrypsin
Haemolysis - Reticulocyte count
- Haptoglobin
- Direct and indirect Coombs’ Test
- G-6-P-D level
Cardiorespiratory - Chest X Ray
Failure - ECG
Gilbert’s Syndrome - Increase in unconjugated bilirubin following
2-3 days on a 400 calorie diet
Unconjungated Hyperbilirubinemia Akibat
Defektive Hepatic Uptake
Jaundice
Unconjugated hyperbilirubinemia