B1Fentanil tetap berefek depresi ventilasi sama dengan morfin. Fentanil tidak menyebabkan
histamine release (aman utk asma)
B2 Fentanil tidak menyebabkan vasodilatasi, fentanyl menyebabkan bradikardiaêBP dan
êCO
B3 Fentanil tetap berefek éICP (despite of unchanged PaCO2). Seizure like activity also in
fentanyl administration.
B6Skeletal muscle Rigidity
Onset: IM 7-15 min; IV 3-7 min
Durasi: IM 1-2 jam; IV 30-60 min
Injeksi 50 mcg/mL
Dosis premedikasi: 50-100 mcg IM atau slow IV (30-60 menit sebelum bedah)
B1Fentanil tetap berefek depresi ventilasi sama dengan morfin. Fentanil tidak
menyebabkan histamine release (aman utk asma)
B2 Fentanil tidak menyebabkan vasodilatasi, fentanyl menyebabkan bradikardiaêBP dan
êCO
B3 Fentanil tetap berefek éICP (despite of unchanged PaCO2). Seizure like activity also in
fentanyl administration.
B6Skeletal muscle Rigidity
Onset: IM 7-15 min; IV 3-7 min
Durasi: IM 1-2 jam; IV 30-60 min
Injeksi 50 mcg/mL
Dosis premedikasi: 50-100 mcg IM atau slow IV (30-60 menit sebelum bedah)
Action
Competitively blocks the effects of opioids,including CNS and respiratory depression,
without producing any agonist (opioid-like) effects. Therapeutic Effects: Reversal of
signs of opioid excess.
Pharmacokinetics
Absorption: Well absorbed after IM or subcut administration.
Distribution: Rapidly distributed to tissues. Crosses the placenta.
Metabolism and Excretion: Metabolized by the liver. Half-life: 60–90 min (up to 3
neonates).
Interactions
Drug-Drug: Can precipitate withdrawal in patients physically dependent on opioid analgesics. Larger
doses may be required to reverse the effects of buprenorphine, butorphanol, nalbuphine, or
pentazocine. Antagonizes postoperative opioid analgesics.