DAFTAR ISI

HALAMAN JUDUL................................................................................................ i
LEMBAR PENGESAHAN.................................................................................... ii
DAFTAR ISI........................................................................................................... iii
BAB I PENDAHULUAN....................................................................................... 1
1.1. Latar Belakang.................................................................................. 1
1.2. Rumusan Permasalahan..................................................................... 2
1.3. Tujuan Penelitian............................................................................... 2
1.4. Manfaat Penelitian............................................................................. 2
BAB II TINJAUAN PUSTAKA....... ..................................................................... 3
2.1

Tinjauan Tentang Parasetamol............................................ 3

2.2

Tinjauan Tentang Ko-Kristal (Rekayasa Materi).................... 5

2.3

Tinjauan Tentang Sediaan Larutan Drop.......................

2.4

Tinjauan Tentang Eksipien. ................................................... 7

2.5

Persyaratan Mutu ............................................................................. 9

BAB III METODE PENELITIAN................................................................

12

3.1. Alat dan Bahan Skala Lab..........................................................

12

3.2. Alat dan Bahan Skala Industri

13

3.3. Perhitungan Dosis .

13

3.4. Perhitungan Jumlah Pelarut.

15

3.5. Acceptable Daily Intake (ADI) .

16

3.6. Rancangan Formula Larutan Drop 15 ml ..

18

3.7. Scalling Up.

19

3.8. Spesifikasi Sediaan

19

BAB IV KERANGKA KERJA..........................................................

21

4.1. Kerangka Konseptual..................................................................

21

4.2. Kerangka Operasional...................................................................... 24

4.3. Rancangan Evaluasi Sediaan .

27

BAB V PEMBAHASAN .

32

BAB V KESIMPULAN.......................................................................................... 36
iii

5.1. Kesimpulan........................................................................................ 36
5.2. Saran.................................................................................................. 36
LAMPIRAN. 37
DAFTAR PUSTAKA............................................................................................... 40

iv