DAFTAR ISI

Halaman
DAFTAR ISI .................................................................................................. i
DAFTAR TABEL .......................................................................................... iv
DAFTAR GAMBAR ...................................................................................... v
DAFTAR LAMPIRAN ................................................................................. vi
BAB I PENDAHULUAN ............................................................................... 1
BAB II TINJAUAN PUSTAKA.................................................................... 5
2.1 Tinjauan umum kayu ............................................................................... 5
2.1.1 Kayu Jelutung ........................................................................... 5
2.1.2 Morfologi ............................................................................ 5
2.1.3 Kandungan dan Manfaat Kayu Jelutung ............................ 6
2.2 Selulosa ...................................................................................................... 6
2.2.1 Sumber Selulosa ................................................................. 6
2.2.2 Jenis - Jenis Selulosa .......................................................... 7
2.3 Mikrokristalin Selulosa ..................................................................... 8
2.3.1 Pembuatan Mikrokristalin Selulosa .................................... 9
2.3.2 Sinonim, Nama Kimia dan Struktur Kimia ........................ 10
2.3.3 Aplikasi Dalam Formulasi Farmasi .................................... 11
2.3.4 Karakteristik Mikrokristalin Selulosa ................................. 11
2.3.5 Stabilitas, Kondisi Penyimpanan dan Keamanan ............... 14
2.4 Uji Sifat Fisika-Kimia Mikrokristalin Selulosa ................................ 14
2.4.1 Uji Organoleptik ................................................................ 14
2.4.2 Susut Pengeringan .............................................................. 14
2.4.3 Uji Kelembaban .................................................................. 14
2.4.4 Pengukuran pH ................................................................... 15
2.4.5 Uji Viskositas ..................................................................... 15
2.4.6 Uji Bobot Jenis dan Kompaktibilitas .................................. 16
2.4.7 Uji Sifat Alir ....................................................................... 17
2.5 Ibuprofen ................................................................................................... 19

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 2.5.1 Sifat Fisikokimia ................................................................ 19
2.5.2 Farmakokinetik ......................................................................... 20
2.5.3 Farmakodinamik ................................................................. 20
2.5.4 Indikasi dan Dosis Terapi ................................................... 20
2.6 Tablet ................................................................................................ 21
2.6.1 Definis tablet....................................................................... 21
2.6.2 Komponen ................................................................................. 22
2.6.3 Metode Pembuatan Tablet ................................................. 23
2.6.4 Macam-macam Kerusakan Pada Pembuatan Tablet .......... 26
2.6.5 Persyaratan Tablet .............................................................. 27
2.6.6 Evaluasi Tablet ................................................................... 29
2.7 Spektrofotometer Ultraviolet Visible (UV-VIS) .............................. 34

BAB III . METODOLOGI PENELITIAN .................................................. 38

3.1 Waktu dan Tempat Penelitian............................................................... 38
3.2 Metoda Penelitian ............................................................................ 38
3.2.1 Alat dan Bahan ................................................................... 38
3.2.2 Rancangan Penelitian ......................................................... 38
3.3. Prosedur Kerja ................................................................................. 39
3.3.1 Pemeriksaan Bahan Baku .................................................... 39
3.3.2 Rancangan Formulasi .......................................................... 40
3.3.3 Pembuatan Granul (Granulasi) ............................................ 40
3.3.4 Evaluasi Granul ................................................................... 41
3.3.5 Pencetakan tablet ................................................................. 45
3.3.6 Evaluasi Tablet .................................................................... 45
3.3.7 Analisis Data........................................................................ 50

BAB IV .HASIL DAN PEMBAHASAN ...................................................... 51

4.1 Hasil ..................................................................................................... 51
4.2 Pembahasan .......................................................................................... 54
BAB V .KESIMPULAN DAN SARAN ........................................................ 64
5.1 Kesimpulan .......................................................................................... 64

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 5.2 Saran ..................................................................................................... 64
DAFTAR PUSTAKA .................................................................................... 65

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 DAFTAR TABEL

Tabel Halaman
1. Kandungan selulosa dalam berbagai bahan tumbuhan ........................ 7
2. Karakteristik MCC dari serbuk kayu jelutung ..................................... 13
3. Formula Tablet Ibuprofen .................................................................... 40
4. Hubungan Antara Faktor Hausner dan Sifat Alir ................................... 43
5. Batas Penyimpangan Keseragaman Bobot........................................... 46
6. Data Hasil Pemeriksaan Zat Aktif dan Badan Tambahan ........................... 71
7. Data Hasil Uji Sifat Granul Ibuprofen.................................................... . 73
8. Data Hasil Pengukuran Distribusi Ukuran Partikel Formula I............. 74
9. Data Hasil Pengukuran Distribusi Ukuran Partikel Formula II ........... 75
10. Data Hasil Pengukuran Distribusi Ukuran Partikel Formula III .......... 76
11. Data Hasil Uji Bobot Jenis Benar ........................................................ 77
12. Data Hasil Evaluasi Bobot Jenis Nyata dan Bobot Jenis Mampat ....... 78
13. Data Hasil Evaluasi Kompresibilitas dan Faktor Hausner ................... 78
14. Data Hasil Uji Kadar Air...................................................................... 79
15. Data Hasil Evaluasi Sudut Diam .......................................................... 80
16. Data Hasil Evaluasi Kadar Air ............................................................. 80
17. Data Hasil Evaluasi Sifat Fisik Tablet Ibuprofen ................................ 81
18. Data Hasil Evaluasi Keseragaman Ukuran Tablet Ibuprofen ................ 83
19. Data Hasil Evaluasi Keseragaman Bobot Tablet Ibuprofen ................ 83
20. Data Hasil Evaluasi Kerapuhan (Friabilitas) Tablet Ibuprofen............ 85
21. Data Hasil Evaluasi Friksibilitas .......................................................... 85
22. Data Uji Waktu Hancur ........................................................................ 86
23. Data Hasil Evaluasi Kekerasan Tablet Ibuprofen ................................ 87
24.
25. HasilPembuatanKurvaKalibrasi Isoniazid Dalam Medium
AquadestPadaPanjangGelombangMaksimum 261,5 nm ..................... 85
26. DataPenetapan Kadar Tablet Isoniazid .................................................... 86
27. HasilPembuatanKurvaKalibrasi Isoniazid Dalam Medium HCL

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 0,01N PadaPanjangGelombang 266,5 nm ........................................... 87
28. Data HasilDisolusi Tablet Isoniazid ......................................................... 89

DAFTAR GAMBAR

Gambar Halaman
1. Kayu jelutung ....................................................................................... 5
2. Struktur Selulosa ................................................................................. 10
3. Rumus Bangun Ibuprofen ................................................................... 19
4. Skema Kerja Formulasi Tablet Granulasi Basah Ibuprofen ................ 69
5. Tablet Ibuprofen .................................................................................. 82
6. Tablet Ibuprofen .................................................................................. 82
7.
8. GrafikUkuranPartikeldenganAyakanVibrasi Formula I ...................... 71
9. GrafikUkuranPartikeldenganAyakanVibrasi Formula II ..................... 72
10. GrafikUkuranPartikeldenganAyakanVibrasi Formula III.................... 73
11. MesinCetak Tablet ............................................................................... 78
12. SpektrumPanjangGelombangMaksimum Isoniazid Dalam Medium
Aquadest ............................................................................................... 84
13. KurvaKalibrasi Isoniazid Dalam Medium Aquadest ........................... 85
14. PanjangGelombangMaksimum Isoniazid Dalam Medium
HCl 0,01N ............................................................................................ 87
15. KurvaKalibrasi IsoniazidDalam Medium
HCl 0,01N ............................................................................................ 88
16. GrafikKurva % DisolusiTablet Isoniazid Formula I, II, dan III ......... 90
17. Tablet Isoniazid .................................................................................... 95

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 DAFTAR LAMPIRAN

Lampiran Halaman
1. Skema Kerja Formulasi Tablet Granulasi Basah Ibuprofen .......................... 69
2. Skema Kerja Pembuatan MCC ...................................................................... 70
3. Data Pemeriksaan Zat Aktif dan Bahan Tambahan ...................................... 71
4. Data Hasil Uji Sifat Fisik Granul Ibuprofen ............................................ 73
5. Data Evaluasi Tablet Ibuprofen ................................................................. 81
6. Data Evaluasi Tablet ................................................................................... 79
7. PenentuanPanjangGelombangMaksimum Isoniazid Dalam Medium
Aquadest ....................................................................................................... 84
8. KurvaKalibrasiIsoniazid Dalam Medium Aquadest ............................... 85
9. Data Penetapan Kadar Tablet Isoniazid ................................................... 86
10. SpektrumPanjangGelombangMaksimum Isoniazid Dalam Medium
HCl 0,01N .................................................................................................... 87
11. KurvaKalibrasi Isoniazid Dalam Medium HCL 0,01N ......................... 88
12. Data HasilEvaluasiTablet Isoniazid .......................................................... 89
13. Tablet Isoniazid ........................................................................................... 95
14.

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