DAFTAR ISI

HALAMAN JUDUL ………………………………………………................. .i

LEMBAR PENGESAHAN ………………………………………………........ ii

DAFTAR ISI ………………………………………………………………….. iv

DAFTAR GAMBAR ………………………………………................................vii

DAFTAR TABEL ……………………………………….................................. viii

I. PENDAHULUAN ………...…………………………….....…………… 1
1.1.Latar Belakang………………………………………………………...1
1.2.Perumusan Masalah …………...…........…….......………………....…3
1.3.Tujuan Penelitian………...……………………………………………4
1.3.1 Tujua umum………………………....………………………4
1.3.2 Tujuan Khusus………...…………………………………….5
1.4 Manfaat Penelitian ...…...…………………………………………......5
1.5. Originalitas………...…………………………………….…………....6

II.TINJAUAN PUSTAKA……………………………………………...................8
2.1. Penyembuhan Luka……………………………………………............……. 8
2.1.1. Fase Inflamasi...................……........…………………….................8
2.1.2. Fase proliferasi……………………………………………........................ 10
2.1.3. Fase Remondeling…………………………………………....................... 12
2.2.Peranan EPC dalam Penyembuhan Luka…………………………............... 13
2..2.Ozon...................……………………………………………........................ 16
2.2.1.MekanismeAksi ………………………………………….............. 17
2.2.2Respon Sel Kulit Terhadap Ozon…………………………………. 21
2.3. Full Thickness Skin Graft..........................………………………………… 22

III. KERANGKA KONSEPTUAL DAN HIPOTESIS ………………….......... 25

3.1. Kerangka Teori ……………………………………………........................ 25
3.2.Kerangka Konsep ………………………………………………………… 26
3.3. Hipotesis Penelitian ……………………………………………………… 26

IV.METODE PENELITIAN ………………………………………………… 27

4.1.Ruang Lingkup Penelitian…………………………………………............ 27
4.2. Rancangan Penelitian………………………………………………......... 28
4.3.Variabel Penelitian ………………………………………………….......... 30
4.3.1.Variabel Bebas ……………………………………………..................... 30
4.3.2.Variabel Tergantung ……………………………………….................... 30
4.4.Definisi Operasional ………………………………………………........... 31
4.5.Cara Pengumpulan Data…………………………………………....... ...... 31
4.5.1.PembuatanOzonated Oil ………………………….……....................... 35
4.5.2.Perlakuan pada Proses Penyembuhan luka………………... ..................... 37
4.5.3.Pemeriksaan Histopatologis ………………………………...................... 40
4.5.4. Parameter dan Data.................................... ………………............ 38
4.6.Alur Penelitian ................................………………………………………… 40
4.7.ProsedurPenelitian.............. ………………………………………………… 41
4.8.Pengolahan dan Analisis Data ……………………………………………… 46
4.9.Persyaratan Etik Penelitian …………………………………………. .......... 47
4.10 Jadwal Penelitian ………................………………………………............ 47

DAFTARPUSTAKA ............................................................................................51
 DAFTAR TABEL

Tabel 1. Orisinalitas Penelitian ....................................................................................... 5

Tabel 2. Populasi Endothelial Progenitor Cell ................................................................ 13

Tabel 3. Efek biokimia ozon dalam darah ....................................................................... 18

Tabel 4. Daerah Donor yang diperhatikan untuk Full thickness Skin Graft ................... 24

Tabel 4. Definisi Operasional.......................................................................................... 31

 DAFTAR GAMBAR

Gambar 1. Infiltrasi sel-sel inflamasi selama cedera ...................................................... 8

Gambar 2. Mekanisme homing dan diferensiasi EPC .................................................... 14

Gambar 3. Metabolisme ozon dalam eritrosit ................................................................ 19

Gambar 4. Mekanisme metabolik pada reaksi ozon Criegee dan aldehide .................... 29

Gambar 5. Kerangka Teori ............................................................................................. 25

Gambar 6. Kerangka Konsep ....................................................................................... 26

Gambar 7. Skema alat reaktor double DBD ................................................................... 34

Gambar 8. Skema alat pembuatan ozonated oil ............................................................. 36

Gambar 9.Alur Penelitian ............................................................................................... 40

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