DAFTAR ISI

Halaman

DAFTAR ISI ....................................................................................... i

DAFTAR GAMBAR .......................................................................... iv
DAFTAR TABEL ............................................................................... v
DAFTAR LAMPIRAN ....................................................................... vi
BAB I PENDAHULUAN ................................................................... 1
BAB II TINJAUAN PUSTAKA ........................................................ 4
2.1 Ikan Gabus (Chana Striata) .................................................... 4
2.1.1 Klasifikasi Ikan Gabus .................................................. 4
2.1.2 Mofologi Ikan Gabus ..................................................... 4
2.1.2 Kandungan Minyak Ikan Gabus .................................... 5
2.1.3 Cara Ekstraksi Minyak Ikan Gabus ............................... 5
2.1.4 Manfaat Minyak Ikan Gabus ......................................... 6
2.2 Mekanisme Asam Omega-3 dan Asam Omega-6 Dalam
Menyembuhkan Luka ............................................................ 7
2.3 Kulit ....................................................................................... 8
2.2.1 Definisi Kulit ................................................................ 8
2.2.2 Lapisan Kulit ................................................................ 9
2.4 Luka ........................................................................................ 12
2.4.1 Definisi Luka ................................................................. 12
2.4.2 Klasifikasi Luka ............................................................. 12
2.4.3 Penyembuhan Luka ........................................................ 13
2.5 Penetrasi Obat Melalui Kulit ................................................... 16
2.6 Emulgel ................................................................................... 17
2.6.1 Definisi Emulgel ............................................................ 17
2.6.2 Keuntungan dan Kerugian Emugel ................................. 17
2.6.3 Bahan Penyusun Emulgel ............................................... 18
2.6.4 Metoda Pembuatan Emulgel .......................................... 19
2.7 Monografi Zat Tambahan ...................................................... 20

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 2.7.1 Hydroxypropyl Methyl Cellulose (HPMC) .................. 20
2.7.2 Parafin Liquid ............................................................... 20
2.7.3 Tween 80 ...................................................................... 21
2.7.4 Span 80 ......................................................................... 21
2.7.5 Propilenglikol ................................................................ 21
2.7.6 Methyl Paraben ............................................................. 22
2.7.7 Propil Paraben ............................................................... 22
2.8 Evaluasi Emulgel .................................................................. 22
2.9 Povidone Iodine .................................................................... 24
2.9.1 Manfaat Povidone Iodine ............................................. 24
2.9.2 Mekanisme Aksi .......................................................... 25
BAB III PELAKSANAAN PENELITAN ........................................ 26
3.1 Waktu dan Tempat Penelitian ............................................... 26
3.2 Metodologi Penelitian ............................................................ 26
3.2.1 Alat yang digunakan ..................................................... 26
3.2.2 Bahan yang digunakan ................................................. 26
3.2.3 Hewan Uji .................................................................... 27
3.3 Rancangan Penelitian ............................................................ 27
3.4 Prosedur Kerja ....................................................................... 28
3.4.1 Pemeriksaan Zat Aktif .................................................. 28
3.4.2 Pemeriksaan Zat Tambahan ......................................... 29
3.4.3 Formulasi Sediaan Emulgel Minyak Ikan Gabus ......... 29
3.4.4 Prosedur Pembuatan Emulgel ...................................... 29
3.4.5 Evaluasi Sifat Fisika Emulgel Ikan Gabus ................... 30
3.4.5.1 Pemeriksaan organoleptis .................................. 30
3.4.5.2 Pemeriksaan pH ................................................. 30
3.4.5.3 Pemeriksaan homogenitas ................................. 30
3.4.5.4 Uji daya sebar .................................................... 30
3.4.5.5 Uji iritasi ........................................................... 31
3.4.5.6 Uji Stabilitas ...................................................... 31
3.4.6 Pengelompokan Hewan Uji ........................................... 32

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 3.4.7 Uji Aktivitas Penyembuh Luka ..................................... 33
3.4.8 Analisis Data ................................................................. 33
DAFTAR PUSTAKA ......................................................................... 34
LAMPIRAN ........................................................................................ 37

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