DAFTAR ISI

Halaman
JUDUL ............................................................................................................... i
LEMBAR PENGESAHAN ............................................................................... ii
LEMBAR PENGUJIAN .................................................................................... iii
KATA PENGANTAR ....................................................................................... iv
ABSTRAK ......................................................................................................... vi
ABSTRACT ......................................................................................................... vii
DAFTAR ISI ..................................................................................................... viii
DAFTAR TABEL .............................................................................................. xi
DAFTAR GAMBAR ......................................................................................... xii
DAFTAR SINGKATAN ................................................................................... xiii
DAFTAR LAMPIRAN ...................................................................................... xiv
BAB 1 PENDAHULUAN ................................................................................ 1
1.1 Latar Belakang .................................................................................. 1
1.2 Rumusan Masalah .............................................................................. 3
1.3 Tujuan Penelitian ................................................................................ 3
1.3.1 Tujuan Umum ............................................................................ 3
1.3.2 Tujuan Khusus ........................................................................... 3
1.4 Manfaat Penelitian .............................................................................. 4
1.4.1 Manfaat Klinis ......................................................................... 4
1.4.2 Manfaat Akademik .................................................................. 4
1.4.3 Manfaat Masyarakat ................................................................ 4
BAB 2 TINJAUAN PUSTAKA ....................................................................... 5

2.1 Labu Siam (Sechium Edule) .................................................................. 5

2.1.1 Taksonomi ..................................................................................... 6
2.1.2 Kandungan Kimiawi dan Manfaat Buah Labu Siam (Sechium edule)
.................................................................................................. 7
2.2 Metabolisme Lemak ............................................................................... 7
2.2.1 Metabolisme Liporotein ................................................................ 11
2.2.2 Klasifikasi Kadar Lipid Plasma .................................................... 16

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2.3 Dislipidemia ........................................................................................... 17

2.3.1 Faktor Resiko Dislipidemia ...................................................... 18
2.3.2 Tes Skrinning Dislipidemia ...................................................... 18
2.3.3 Klasifikasi Dislipidemia ........................................................... 19
2.4 Pengaruh Ekstrak Labu Siam (Sechium edule) Terhadap Perbaikan Profil
Lipid .................................................................................................. 20

BAB 3 KERANGKA KONSEP DAN HIPOTESIS ......................................... 24

3.1 Kerangka Konsep .................................................................................. 24

3.2 Hipotesis................................................................................................. 25

BAB 4 METODE PENELITIAN....................................................................... 26

4.1 Rancangan Penelitian .......................................................................... 26

4.2 Tempat dan Waktu Penelitian ............................................................. 26
4.3 Populasi dan Sampel ........................................................................... 26
4.3.1 Populasi .................................................................................... 26
4.3.2 Sampel ...................................................................................... 26
4.3.3 Estimasi Besar Sampel ............................................................. 26
4.4 Karakteristik Sampel Penelitian ........................................................... 28
4.4.1 Kriterian Inklusi ....................................................................... 28
4.4.2 Kriteria Eksklusi....................................................................... 28
4.5 Variabel Penelitian ............................................................................... 28
4.5.1 Variabel Bebas ......................................................................... 28
4.5.2 Variabel Terikat ....................................................................... 28
4.6 Definisi Operasional ............................................................................ 28
4.7 Alat dan Bahan ..................................................................................... 30
4.7.1 Alat ........................................................................................... 30
4.7.2 Bahan........................................................................................ 31
4.8 Prosedur Penelitian .............................................................................. 31
4.8.1 Adaptasi Hewan Percobaan...................................................... 31
4.8.2 Pembuatan Ekstrak Buah Labu Siam (Sechium edule) ............ 31
4.8.3 Penentuan Dosis Ekstrak Buah Labu Siam (Sechium edule) ... 32
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4.8.4 Perlakuan Pada Tikus ............................................................... 32

4.8.5 Proses Anastesi dan Pembedahan Hewan Coba ...................... 34
4.8.5.1 Proses Anastesi ............................................................... 34
4.8.5.2 Proses Pembedahan ........................................................ 34
4.8.6 Pemeriksaan Lipoprotein Plasma ............................................. 34
4.9 Alur Penelitian ..................................................................................... 40
4.10Analisa Data ......................................................................................... 41

BAB 5 Hasil Penelitian dan Analisa Data ......................................................... 42

5.1 Hasil Penelitian .....................................................................................42

5.2 Analisa Data ......................................................................................... 43
5.2.1 Uji Normalitas .......................................................................... 43
5.2.2 Analisis One-Way ANOVA ..................................................... 43
5.2.3 Uji HSD Tukey 5% ...................................................................44
5.2.3.1 Uji HSD Tukey 5% Kadar Kolesterol Total Tikus Putih
.........................................................................................45
5.2.3.2 Uji HSD Tukey 5% Kadar Trigliserida Tikus Putih ........45
5.2.3.3 Uji HSD Tukey 5% Kadar LDL Tikus Putih...................46
5.2.3.4 Uji HSD Tukey 5% Kadar HDL Tikus Putih ..................47
5.2.3.5 Uji HSD Tukey 5% Rasio LDL/HDL Tikus Putih ..........47
5.2.3.6 Uji HSD Tukey 5% Rasio KT/HDL Tikus Putih ............48
5.2.4 Uji Korelasi ...............................................................................49
5.2.5 Uji Regresi ................................................................................50

BAB 6 PEMBAHASAN .....................................................................................52

BAB 7 KESIMPULAN DAN SARAN ..............................................................59

7.1 Kesimpulan ...........................................................................................59

7.2 Saran .....................................................................................................59

DAFTAR PUSTAKA .........................................................................................60

LAMPIRAN ........................................................................................................63