Waktu (t) Ct µg/mL LnCp

0.5 0.699 -0.35810454

1 0.622 -0.47481519
2 0.413 -0.88430769
2.5 0.292 -1.23100148
4 0.152 -1.88387476
6 0.06 -2.81341072
8 0.024 -3.72970145

Parameter
Farmakokinetik Hasil Persamaan Farmakokinetik Monokompartemen
Ke (jam) 0.459 Ln Cp = Ln Cp°-k.t
t 1/2 (jam) 1.5098039216 Ln Cp = 0.0514-0.459.t
Ln C0 0.0514
C0 1.0527439066
Dosis i.v (mg) 160
Vd (mL) 151.98378161
Cl (mL/jam) 69.76055576
AUCo~ (µg/mL.jam) 2.2935597095
 Grafik Obat Monokompartemen
0
0 1 2 3 4 5 6 7 8 9
-0.5 f(x) = - 0.4589881538x - 0.0513571599 Ln Ct = Ke.t + Ln
Co
konsentrasi Plasma (µg/mL)

R² = 0.9983634399
-1
-1.5
Oxpropanolol
-2 Linear (Oxpropanolol)
-2.5
-3
-3.5
-4
Waktu (jam)
 Kadar Obat dalam
Waktu (jam) LnCp Ln C' C' Cr
darah (µg/mL)
0.25 53.8 3.9852735 2.796675 16.39006 37.40994088
0.5 43.3 3.7681526 2.76525 15.88301 27.41698975
0.75 35 3.5553481 2.733825 15.39165 19.60835238
1 29.1 3.3707382
1.5 21.2 3.0540012
2 17 2.8332133
3 12.6 2.5336968
4 10.5 2.3513753
5 9 2.1972246
6 8 2.0794415
7 7 1.9459101

Persamaan Parameter Hasil

y = bx + a α 1.292
y = -1.292x + 3.949 Ln A 3.949
A 51.883457
y = bx + a β 0.1257
y = -0.1257x + 2.8281 Ln B 2.8281
B 16.913295

Parameter Farkin Rumus Persamaan Farmakokinetik Multikompartemen

K (/Jam) 0.3937760804 Ln Cp = Ln A-a.t + Ln B-b.t
K12 (/jam) 0.6114956181 Ln Cp = 3.949-1.292.t + 2.8281-0.1257.t
K 21 (/Jam) 0.4124283015
t 1/2 5.5131264916
Vp (mL) 0.7267784921
AUCo~ (mg/ml.jam) 174.7103388792
Cl (ml/jam) 0.2861879859
 LnCr
Grafik Obat Multi Kompartemen
3.621936
3.311163 4.5
Grafik Obat Multi
2.975956 4 Kompartemen
3.5 Linear (Grafik
1.2919617014x + 3.6885509409
f(x) = - 0.2870866177x 3.9489991742 Obat Multi
Konsentrasi (µg/mL)

3 0.9995233382
R² = 0.8978245159
Ln Kompartemen)
Ct = β + Ln B
2.5 Fase Eliminasi
2 f(x) = - 0.1256572141x +Linear (Fase
2.8281353742
1.5 R² = 0.9986927871 Ln Eliminasi)
Ct = α + Ln A

1 Fase Distribusi
Linear (Fase
0.5 Distribusi)
0
0 1 2 3 4 5 6 7 8
Waktu (jam)
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Ln B
inasi
ase
53742
Ln
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