Pengaruh Pemberian Heat-Killed Probiotic Complex

Terhadap Perbaikan Malabsorpsi Laktosa pada Anak dengan Diare Akut

Abstrak

Latar belakang : Malabsorpsi laktosa dapat terjadi pada diare akut karena
kerusakan mukosa usus dan penurunan enzim laktase. Pemberian Heat-Killed
Probiotic Complex diharapkan dapat memperbaiki malabsorpsi laktosa pada diare
akut karena stabil pada suhu tertentu dan mengandung enzim laktase. Tujuan :
Meneliti pemberian Heat-Killed Probiotic Complex terhadap perbaikan malabsorpsi
laktosa pada anak dengan diare akut, dengan melihat peningkatan pH tinja dan
penurunan substansi reduksi tinja. Metode : Penelitian uji klinis pre-post test design
di Bagian Ilmu Kesehatan Anak RSU Dr. Soetomo Surabaya pada Maret-Agustus
2008, meliputi 28 anak usia 6-24 bulan dengan diare akut dehidrasi ringan-sedang,
gizi baik atau kurang, mendapat ASI/PASI, pH tinja kurang dari 5,5 dan Clinitest
positif,  tidak menerima probiotik, antibiotik, vitamin A dan zinc. Dilakukan matching
variabel umur, jenis kelamin, status gizi, dan derajat dehidrasi. Data pH tinja dan
Clinitest diperiksa sebelum dan sesudah hari ke-4 penelitian. Hasil analisa diuraikan
secara deskriptif dan uji statistik. Hasil : 14 anak setelah dilakukan matching varibel
dibagi menjadi dua kelompok: 7 diberikan Heat-Killed Probiotic Complex dan 7
plasebo. Tidak terdapat perbedaan bermakna pada peningkatan pH tinja dan
penurunan substansi reduksi tinja pada kedua kelompok (p>0.05). Simpulan : Heat-
Killed Probiotic Complex tidak dapat digunakan untuk meningkatkan pH tinja dan
menurunkan substansi reduksi tinja pada anak diare akut dengan malabsorpsi
laktosa.

Created by :
Maria Christina Shanty Larasati, dr.

Contributor :
Prof. Dr. H. Subijanto Marto Sudarmo, dr., SpA(K)
Dr. IGM. Reza Gunadi Ranuh, dr., SpA(K)
Alpha Fardah Athiyyah, dr., SpA
Budiono, dr., MKes

Departemen / SMF Ilmu Kesehatan Anak

Fakultas Kedokteran Universitas Airlangga
Rumah Sakit Dr Soetomo Surabaya
2009

Heat Killed Probiotic Complex Treatment of Lactose Intolerance in Children

With Acute Diarrhea

Abstract

Background : Lactose intolerance can occur in acute diarrhea caused by intestinal

mucous damage and lactase deficiency. Heat-Killed Probiotic Complex which more
stable in certain temperature and had lactase can treat lactose intolerance in
children with acute diarrhea.
Objective : To examine Heat-Killed Probiotic Complex about improving of lactose
intolerance in children with acute diarrhea, with parameter of increasing of stool pH
and decreasing of fecal reducing substances. Methods : This study was a clinical
trial with pre-post test design was conducted in March-August 2008 in Pediatric
Department Soetomo Hospital. All charts of 28 children with acute diarrhea aged 6-
24 months old, mild until moderate dehydration, had a good nutrition status or mild
malnutrition, take breast or formula feeding, stool pH less than 5.5 and positif
Clinitest, never use probiotic, antibiotic, vitamin A, nor zinc. Variable matching about
age, sex, nutrition status, and dehydration status was done. Stool pH and Clinitest
was check before and day 4th after intervention. Outcome will be described and
analized. Result : Fourteen children after variable matching divided into two groups:
7 children received Heat-Killed Probiotic Complex and 7 children had placebo. There
were no significant difference in increasing of stool pH and decreasing of fecal
reducing substances between these two groups (p>0.05). Conclusion : Heat-Killed
Probiotic Complex can not use to increase pH stool and decrease fecal reducing
substances