Urinary System
Peran Fungsi
Mengatur keseimbangan dan komposisi
cairan tubuh.
Mengatur keseimbangan asam basa.
Mengatur tekanan darah.
Mengatur metabolisme tulang.
Mengatur produksi sel darah merah.
Gangguan Fungsi Ginjal
Klinis
Tanda, gejala, pemeriksaan fisik.
Laboratoris
Ureum, kreatinin, asam urat
Tes Klirens Kreatinin (TKK)
Kreatinin urin(mg/dl) x Vol. Urin(ml/24jam)
Kreatinin serum(mg/dl) x 1440
Rumus Cockroft-Gault
(140-umur) x BB(kg)
LFG =
72 x kreatinin serum(mg/dl)
LFG
Tahap Deskripsi (mL/min/1,73 m3) Tindakan
>=90 Screening
(dgn resiko PGK) Mengurangi resiko PGK
Ggn fungsi ginjal Diagnosis dan pengobatan
1 Kronik dgn LFG >= 90 Mengobati penyakit penyerta,
tinggi/Normal/ memperlambat perburukan,
turun mengurangi risiko jantung
2 Penurunan LFG 60 89 Memperkirakan perburukan
ringan
3 Penurunan LFG 30 - 59 Evaluasi dan mengobati komplikasi
sedang
4 Penurunan LFG 15 - 29 Persiapan untuk TPG
Berat
5 Gagal ginjal < 15 Terapi Pengganti Ginjal (TPG) bila
(atau dialisis) ada uremi
Terapi Pengganti Ginjal Terintegrasi
Terapi
Pengganti
Ginjal
CAPD HD
Transplantasi
Kendala Transplantasi Ginjal
Jumlah donor tidak memadai
Penolakan(Rejection)
Tehnik operasi
Cost
Hemodialisis (HD)
Peritoneal Dialysis
Difusi Osmosis
KLIRENS ULTRAFILTRASI
Principles of peritoneal dialysis. In the three pore model of
peritoneal transport (a), the smallest pores probably represent
aquaporins. Diffusion from capillaries into the peritoneal cavity
(b) depends on the intrinsic permeability of capillaries and also
on the number of perfused capillaries (the effective surface area)
Principles of peritoneal dialysis. In the three pore model of
peritoneal transport (a), the smallest pores probably represent
aquaporins. Diffusion from capillaries into the peritoneal cavity
(b) depends on the intrinsic permeability of capillaries and also
on the number of perfused capillaries (the effective surface area)
A recently implanted peritoneal dialysis catheter in situ
Continuous Ambulatory
Peritoneal Dialysis (CAPD)
Peritoneal Dialisis