HIPERTENSI Nurul Hikmah

21161091
PERTANYAAN
Seorang pasien wanita berusia 27 sedang dalam masa kehamilan trimester kedua.
Hasil pemeriksaan menunjukkan HDL 60 mg/dL, LDL 100 mg/dL, serum kreatinin 1,3
mg/dL dan tekanan darah 140/90 mmHg. Obat yang dikontraindikasikan pada
pasien tersebut adalah?

A. Methyldopa
B. Metoprolol
C. Labetalol
D. Kandesartan
E. Nifedipin
JAWABAN : D. KANDESARTAN

Pharmacotherapy Principles and Practice, 2016

D. KANDESARTAN
Kandesartan : Golongan ARB -> KONTRAINDIKASI untuk wanita hamil

Drugs During Pregnancy and Lactation, 2015

medscape.com

PIO KANDESARTAN
Indikasi: hypertension, heart failure
Golongan obat: Angiotensin Receptor
Blockers
Dosis:
Adult : PO
HTN Initial: 8 mg once daily. Max: 32
mg/day as single or in 2 divided doses.
Heart failure Initial: 4 mg once daily. May
be doubled at intervals of not <2 wk. Max:
32 mg once daily.
Tata cara dan aturan pakai: 1x sehari 1
tablet
Efek samping: Dizziness, headache, vertigo,
back pain, upper resp tract infections,
pharyngitis, rhinitis, hypotension,
hyperkalaemia, increased serum creatinine.
Kontra indikasi: History of angioedema.
Severe hepatic impairment or cholestasis.
Concomitant use w/ aliskiren in patients w/
DM. Pregnancy
Interaksi Obat: NSAIDs may reduce
antihypertensive effect and result in
deterioration of renal function including
possible acute renal failure. May increase
serum lithium concentration. K-sparing
diuretics, K supplements or salt substitutes
containing K may increase risk of
hyperkalaemia.
Potentially Fatal: Coadministration w/
aliskiren in diabetic patients may increase
risk of renal impairment, hypotension and
hyperkalaemia.
www.mims.com
TERIMAKASIH