Teknologi Farmasi

Sediaan Padat

Perhitungan dan Pencetakan Tablet

Dosen Pengampu MK :
Nessa Agistia, M. Farm., Apt

KELOMPOK 5
S1- VI.B
Section Break

1. Dellaviana Ariska (160100

2. Nurdina Putri (1601033)
3. Yulinda Anggraini
4. Sandika Syaputra
5. Suci Rizki Aulia R.
Outline

01 Pendahuluan

Perhitungan Tablet Granulasi

02 Basah & Cara Pembuatan

Perhitungan Tablet Granulasi

03 Kering & Cara Pembuatan

Perhitungan Tablet Cetak

04 Langsung & Cara Pembuatan
 1. Metode Granulasi Basah
a. Fase dalam
 Zat aktif, Pengisi, Pengikat, Desintegran,
Lubrikan, dan Antiadheren
Pendahuluan b. Fase Luar
 Lubrikan dan Glidan

2. Metode Granulasi Kering

a. Fase dalam
 Zat aktif, Pengisi, Pengikat, Desintegran,

b. Fase Luar
 Lubrikan, Glidan dan Desintegran

Komposisi Bahan 3. Metode Granulasi Kering

 Zat aktif
 Desintegran
 Lubrikan
 Pengisi
Formulasi Tablet Granulasi Basah
Bobot dalam Bobot dalam 100
Nama Bahan Kegunaan
Satu Tablet Tablet
Paracetamol 500 mg 50 gram Zat aktif
Laktosa 92 mg 9,2 gram Pengisi
Amprotab 75 mg 7,5 gram Disintegran,
pengikat
Amilum MA 230 mg 23 gram Pengikat
Mg-stearat 7,525 mg 0,745 g Lubrikan
Talk 15,04 mg 1,489 g Antiadheren
dan Glidan
Amprotab 37,59 mg 3,722 g Disintegran,
pengikat
Formulasi I
Tablet Cetak Langsung

Nama Bahan Bobot dalam Bobot dalam Kegunaan

1 Tablet 500 tablet

Vitamin c 300 mg 150 gram Zat Aktif

Amylum 25 mg 12,5 gram Desintegrant

Mg. Stearat 10 mg 5 gram Lubrikan

Talk 25 mg 12,5 gram Pelicin

Avicel PH 102 140 mg 70 gram Pengisi

Perhitungan Tablet Kempa Langsung

Formula Tablet Vitamin C yang akan dibuat :

 Bobot 1 tablet : 500 mg
 Jumlah tablet : 500 tablet
R/ Vitamin C = 300 mg
Amylum5% x 300 mg= 25 mg
Mg. Stearat 2% x 300 mg = 10 mg
Talk 5% x 300 mg = 25 mg
Avicel PH 102 = 500 mg- (300 mg+25 mg+10 mg+25 mg) = 140 mg

Penimbangan Bahan-Bahan :
 Vitamin C = 300 mg x 500 tab = 250.000 mg = 250 gram
 Amylum = 25 mg x 500 tab = 12.500 mg = 12,5 gram
 Mg. Stearat = 10 mg x 500 tab = 5.000 mg = 5 gram
 Talk = 25 mg x 500 tab = 12.500 mg = 12,5 gram
 Avicel PH 102 = 140 mg x 500 tab = 70.000 mg = 70 gram
 Cara Pembuatan

Siapkan alat dan bahan Campurkan vitamin C, Lakukan uji sifat alir
yang diperlukan Amylum dan Avicel ad dan uji kompresibilitas
homogen, (Campuran campuran A.
A).

 Cetak tablet dengan menggunakan mesin Campur Mg.stearat dan

pencetak tablet. talk ke dalam
 Lakukan uji evaluasi tablet.
campuran A.
 Masukkan tablet ke dalam wadah dan
kemasan yang sesuai
Formulasi II
Tablet Cetak Langsung
Nama Bahan Bobot Dalam Bobot Dalam Kegunaan
1 Tablet 500 tablet
Chlorpheniramin 4 mg 2 gram
Maleat (CTM) Zat Aktif

Amilum Manihot 10 mg 5 gram

Desintegrant

Mg. Stearat 2 mg 1 gram

Lubrikan

Talk 2 mg 1 gram
Pelicin

MCC 182 mg 91 gram

Pengisi
Perhitungan Tablet Cetak Langsung

Formula Tablet CTM yang akan dibuat :

 Bobot 1 tablet : 200 mg
 Jumlah tablet : 500 tablet
R/ CTM = 4 mg
Amylum Manihot 5% x 200 mg = 10 mg
Mg. Stearat 1% x 200 mg = 2 mg
Talk 1% x 200 mg = 2 mg
MCC = 200 mg- (4 mg+10 mg+2 mg+2 mg) = 182 mg

Penimbangan Bahan-Bahan :
 CTM = 4 mg x 500 tab = 2.000 mg = 2 gram
 Amylum Manihot = 10 mg x 500 tab = 5.000 mg = 5 gram
 Mg. Stearat = 2 mg x 500 tab = 1.000 mg = 1 gram
 Talk = 2 mg x 500 tab = 1.000 mg = 1 gram
 MCC = 182 mg x 500 tab = 91.000 mg = 91 gram
 Cara Pembuatan
4.  Tambahkan sedikit demi
sedikit selulosa mikrokristal
sambil terus digerus sampai
semua    komponen
2. masukkan homogen..
klorfeniramin maleat ke
dalam lumpang, 6. Lakukan uji evaluasi
kemudian ditambahkan tablet. Dan Masukkan
dengan amilum manihot tablet ke dalam wadah
dan kemasan yang
sesuai

5. Cetak tablet dengan

menggunakan mesin
pencetak tablet.
3. tambahkan
magnesium stearat
1. Siapkan alat dan dan talkum sambil
bahan yang digerus.
diperlukan
.
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