GANGGUAN SIRKULASI
Drh. Putri Pandarangga, MS
15 Mei 2016
Untuk memudahkan kalian belajar, silakan buka website ini ya:
http://vet.uga.edu/ivcvm/courses/VPAT5200/01_circulation/index.php
Kasus 1.
Pada saat kamu melakukan nekropsi dan menemukan lesio seperti di
bawah ini, maka ceritakan hal apa yang berada dalam pikiran anda!
Morfologi diagnosa?
Patogenesis! Penyebabnya yang berhubungan dengan jantung!
Kasus 2
Sebutkan kemungkinan
mekanismenya!
yang
dapat
sebabkan
lesion
ini!
Serta
Swollen, usually soft and doughy, distended tissue that tends to gravitate ventrally
Edematous tissue pits on pressure and the indentations remain after the pressure is
removed
Edematous tissue is cool to the touch rather than warm (unless inflammation is also
present)
The edematous tissue is not reddened (not hyperemic) or painful (again, unless
inflammation is also present)
At postmortem examination, edema is recognized by the presence of clear yellowtinged fluid that distends loose connective tissues or accumulates in body cavities
such as the peritoneal, pleural, or pericardial spaces. The fluid may flow upon cutting
through the tissue or, if the vessels were damaged sufficiently that clotting proteins
accompanied the fluid, it may form a yellowish jello-like clot.
separation of tissue elements by spaces that are either clear (if the edema is proteinpoor) or pink (if the edema fluid has abundant protein).
dilation of lymphatics
Kasus 3
Pada saat kalian menjadi seorang dokter hewan, sangat dibutuhkan
kepercayaan diri untuk mendiagnosa suatu penyakit. Tapi kepercayaan
diri itu akan tercipta bila dari sekarang kalian mulai memperkaya diri
kalian dengan pengetahuan ttg doker hewan. Ok, kita mulai dari
sekarang ya!
Berikut gambar anjing dengan perut yang membesar. Kemungkinan
yang terjadi adalah:
Kasus 4
Pada gambar di bawah ini meruapkan jantung dari domba yang mati
secara mendadak. Sebutkan morfologi diagnosanya! Apa hubungannya
lesion ini dengan kematian mendadak?
Morphologic diagnosis: Serofibrinous pericardial effusion (at this stage of your training, I
would also give you full points for hydropericardium)
What was the immediate reason for death? Cardiogenic shock - the heart could not pump
the blood around and so there was multisystem organ failure due to lack of oxygen.
In fact this lamb had white muscle disease (lack of Vitamin E/selenium) so there was
myocardial failure.
This is a
picture of
lymphosarco
ma in a cow
heart, so
heck, this
heart isn't
working so
well anymore.
With all these
tumor blobs,
the heart
can't function
so good, and
there is poor
cardiac
output.
Kasus 5
Pelajari dan mengerti bagaimana terjadi pembekuan darah dimana
melibatkan platelet (hemostatis sementara) dan faktor koagulasi
(hemostatis permanen). Selain itu bagaimana platelet dihambat
kerjanya yang dikenal sebagai antikoagulasi!
Here are the factors that the endothelial cell produces and how those factors have a role in
anticoagulation:
It also prevents platelet aggregation by acting on platelets to increase cyclic AMP (cAMP)
that effectively reduces the amount of thromboxane A2 (which is made by platelets and
which we will cover shortly) which has procoagulant activities.
What happens if the endothelial cell is damaged? : Oops. Endothelial cells get
damaged and there is decreased PGI2. As a result, vessel constricts a bit, cAMP
in platelets decreases, causing a thromboxane increase, causing platelet
aggregation.
The endothelium produces nitric oxide in response to ADP from activated platelets. This
nitric oxide works to keep the vessel open (vasodilation), which decreases the probability
of clotting.
Protein C is released from the endothelium in response to thrombin (a very important
molecule in the whole clotting thang and we'll hear about thrombin very soon). This Protein
C acts to inactive some of the clotting factors.
A heparin-like substance is produced on the surface of endothelial cells that acts to
inactivate thrombin.
Endothelial cells act to help clot dissolution by releasing plasminogen activators.
Plasminogen is a key molecule involved in breaking clots down after they have formed.
Okay, for review, here are the products of endothelial cells - How does each work to
decrease thrombosis?
prostacyclin
adenosine diphosphatase
nitric oxide
Protein C
heparin-like substance
plasminogen activators
Kasus 6.
Jelaskan perbedaan lesio yang terjadi pada gambar di atas!
Mekanisme hingga terjadi lesio tersebut.
They are arterial infarcts because they are all very pale.
There is not much collateral circulation in the kidney and once
the arcuate arteries (found at the junction of cortex and
medulla) get blocked, the corresponding portion of the cortex
gets pale and ischemic.