Diagnosis banding nyeri abdomen akut berdasarkan lokasi nyeri :

Epigastrium : pankreatitis, ulkus duodenum, ulkus gaster, kolesistitis, kanker

pankreas, hepatitis, obstruksi intestinal, apendisitis(gejala awal), abses
subfrenikus, pneumonia, emboli paru, infark miokard.

Diagnosis banding nyeri abdomen kronis : (At a Glance Ilmu Bedah Ed. 3 hal 31)

Angina mesentrika
Divertikulum meckel
Syndrom iritasi usus
Pankreatitis kronis
Kolesistitis kronis