DAFTAR OBAT BAKSOS
OAINS
1. Paracetamol (500 mg)
Adult: 325-650 mg PO/PR q4hr
PRN, or 1000 mg PO q6-8hr
PRN; not to exceed 4 g/day
Pediatric
<12 years: 10-15 mg/kg PO
q4-6hr PRN; not to exceed
2.6 g/day (5 doses/24
hours)
>12 years: 40-60
mg/kg/day PO divided q6hr
PRN; not to exceed 3.75
g/day (5 doses/24 hours)
2. Ibuprofen (200 mg, 400 mg)
Adult: 200-400 mg PO q4-6hr;
not to exceed 1.2 g unless
directed by physician
Pediatric: 5-10 mg/kg/dose PO
q6-8hr; not to exceed 40
mg/kg/day
3. Antalgin (500mg)
Indikasi: sakit kepala
Migraine flunarizine
Dewasa: Antalgin mg500 tab no. X
2 dd tab 1
4. Meloxicam (7,5 mg; 15 mg)
Adult: 7.5-15 mg PO qDay; not to
exceed 15 mg/day
5. Piroxicam (10 mg, 20 mg)
Adult :20 mg PO qD or div BID;
no more than 30-40 mg/d
Berikan obat lambung - 1 jam
sebelum minum obat.
6. Asam Mefenamat (500 mg)
Adult: Initial 500 mg PO once, THEN
250 mg PO q6hr PRN usually not to
exceed 7 days
7. Na Diklofenak (50 mg)
Adult: 50 mg PO q8hr or 75 mg PO
q12hr
8. Aspilets (500 mg)
Pada baksos diberikan untuk orang
resiko stroke (efek antikoagulopati)
Dewasa: Asetosal mg80 tab no. III 1
dd tab 1
Anti Hipertensi
1. Captopril (12,5 mg; 25 mg)
Adult: 25 mg PO q8-12hr, increase
gradually based on response (may
start lower in some patients)
2. HCT (25 mg)
Adult: 12.5-50 mg PO once daily
Jangan dikasih pada pasien DM atau
hiperuria.
3. Amlodipine (5 mg)
Adult: 5 mg/day PO initially; may
be increased by 2.5 mg/day every
7-14 days; not to exceed 10
mg/day PO; maintenance: 5-10
mg/day
4. Nifedipine (10 mg)
Adult:
10 mg (conventional) PO q8hr
or 30-60 mg (extended release)
PO once daily initially; may be
increased every 7-14 days PRN
Maintenance: 10-20 mg
(conventional) PO q8hr up to
20-30 mg PO q6-8hr; not to
exceed 180 mg/day
(conventional) or 120 mg/day
(extended release)
Step 1 <55 th = A; >55 th = C atau D
Step 2 = 2 obat (A + C atau A + D).
 1. Simvastatin (10 mg)
Adult: 1 dd tab 1 0-0-1

Anti Diabetes Antibiotik, Anti Jamur, Anti Parasit

1. Metformin (500 mg) 1. Amoxicilin (500 mg)

Adult: 2. Chloramphenicol (250 mg)
Initial: 500 mg PO q12hr or 850 3. Ciprofloxacin (500 mg)
mg PO qDay with meals; 4. Cotrimoxazole (Trimethoprom 80 mg,
increase q2Weeks sulfamethoxazole 400 mg)
Maintenance: 1500-2550 5. Tetracyclin (500 mg)
mg/day PO divided q8-12hr with 6. Metronidazole (500 mg)
meal 7. Ketoconazole (200 mg)
2. Glibenclamide (5 mg)
Dewasa: Glibenklamid mg5 tab no. VII
Obat Batuk
1 dd tab 1 h ac mane (1-0-0)
1. Gliseril Guaiacolat (100 mg)
2. Ambroxol (30 mg)
Anti Asam Urat
3. Bromhexin (8 mg)
1. Kolkisisn (0,5 mg) 4. Gantusif (Dextromethorpan HBr 15 mg,
Adult Gliseril Guaiacolat 50 mg,
Treatment of acute gout flares: Diphenhydramin HCl 5 mg)
1.2 mg PO at first sign of flare,
3 dd tab 1
then 0.6 mg 1 hr later; not to
exceed 1.8 mg in 1-hr period
Prophylaxis: 0.6 mg PO once
daily or q12hr; not to exceed Obat Flu
1.2 mg/day; after gout flare,
wait 12 hr to continue 1. Alpara (Aceraminophen 650 mg,
prophylaxis Phenylpropanolamine HCl 15 mg,
2. Piroxicam (20 mg) Dextromethorpan HBr 1 mg,
Adult:20 mg PO qD or div BID; no Chlorpheniramine maleat 2 mg
more than 30-40 mg/d 2. Demacoline (Paracetamol.
3. Allopurinol (100 mg) Chlorpheniramine maleat 2 mg,
Mild: 100 mg/day PO initially; psudoefedrin HCl)
increased weekly to 200-300 3. Flucadex (Paracetamol, Gliseril
mg/da Guaiacolat 50 mg, Dextromethorpan
Moderate to severe: 100 HBr 1 mg, Phenylpropanolamine HCl 15
mg/day PO initially; increased mg)
weekly to 400-600 mg/day 4. Tera F (Aceraminophen 650 mg,
Phenylpropanolamine HCl 15 mg,
Anti Kolestrol
 Gliseril Guaiacolat 50 mg,
Chlorpheniramine maleat 2 mg)
5. Elsiron (Aceraminophen 650 mg,
Phenylpropanolamine HCl 15 mg,
Gliseril Guaiacolat 50 mg,
Chlorpheniramine maleat 2 mg)
6. Calortusin (Aceraminophen 500 mg,
Phenylpropanolamine HCl 15 mg,
Dextromethorpan HBr 1 mg,
Chlorpheniramine maleat 2 mg)
7. Hufagrip (Aceraminophen 500 mg,
Ephedrin HCl 15 mg, Dextromethorpan
HBr 1 mg, Chlorpheniramine maleat 2
mg
Pseudoefedrin hcl dekongestan, turunkan
sekresi mucus.
3 dd tab 1
Obat Lambung
1. Antasida (200 mg)
Dewasa: 3 dd tab 1 ac manduso
2. Omeprazole (20 mg)
Dewasa: 20 mg PO qDay for 4-8
weeks
3. Ranitidine (150 mg)
Adult: 150 mg PO q12hr or 50 mg
IM/IV q6-8hr
4. Cimetidine (200 mg)
Adult: 400 mg PO q12hr OR
Adult: 5-10 mg PO qDay,
depending on severity of
symptoms; not to exceed 10 mg
qDay
Pediatric:
2-6 years: 2.5 mg (0.5
teaspoon) oral solution PO
qDay; can increase to 5 mg
PO qDay or 2.5 mg PO twice
daily; not to exceed 5 mg
qDay
>6 years: 5-10 mg PO qDay,
depending on severity of
symptoms; not to exceed 10
mg qDa
2. Cyphoheptadine (4 mg)
Adult: 4 mg PO q8hr initially;
maintenance: 4-20 mg/day, up
to 32 mg/day divided q8hr in
some patients; not to exceed
0.5 mg/kg/day
Pediatric:
2-6 years old: 2 mg PO q8-
12hr; not to exceed 12
mg/day
7-14 years old: 4 mg PO q8-
12hr; not to exceed 16
mg/day
3. Chlorfeniramine Maleat
1 dd tab 1 0-0-1
Obat Topikal (2 x 1 ue)

Kortikosteroid 1. Hydrocortisone (2,5%)

2. Miconazole (2%)
1. Dexamethasone (0,5 mg) 3. Gentamicyn (1 mg)
2. Prednison (5 mg) 4. Acyclovir (5 mg)
3. Methylprednisolon (4 mg) 5. Lotte (tetes mata steril)

Antihistamin Vitamin

1. Cetirizine (10 mg) 1. Caviplex

2. Neurodex
3. Ramabion Extended release: 40 mg PO
4. Vit B-plex initially; maintenance: 40-80
5. Vit C (50 mg) mg PO q8-12hr
2. Furosemide (40 mg)
Pemakaian 1 dd tab 1, kecuali vit B dan C 2 Dewasa: 20-80 mg PO once daily;
dd tab 1 may be increased by 20-40 mg q6-
8hr; not to exceed 600 mg/day

Obat Diare

1. Enterostop (Attaplugite, Pectin) Anti Emetic

2. Akita (Attaplugite 600 mg, Pectin 50
mg) 1. Domperidone (10 mg)
2. Dewasa dan usia lanjut : 10-20 mg,
Dewasa 2 tab setelah diare prn, anak 1 tab 3 kali sehari dan jika perlu 1020
setelah diare prn. mg, sekali sebelum tidur malam
tergantung respon klinik.
Pengobatan jangan melebihi 12
Obat Saluran Nafas minggu
3. Metoclorpramide (10 mg)
1. Salbutamol (2 mg, 4 mg) Adult: 2 mg/kg IV (infused over at
Dewasa least 15 minutes) 30 minutes
(>12 tahun) : 2-4 mg, 3-4 kali before chemotherapy, then
sehari. repeated 2 more times q2hr (after
Dosis dapat dinaikan secara initial dose)
berangsur.
Obat Psikotik
Untuk lansia diberikan dosis
awal yang lebih rendah. 1. Amitriptiline (25 mg)
Anak-anak: Antidepresan
2-6 tahun : 1-2 mg, 3-4 kali 1dd tab 1
sehari 2. Diazepam
6-12 tahun: 2 mg, 3-4 kali Antianxietas
sehari. 1 dd tab 1
2. Teosal (Salbutamol Sulfate 1 mg,
Teophyline 150 mg)
Anti Vertigo
Obat Jantung 1. Betahistine (6 mg)
Dewasa: 3 dd tab 1 prn
1. Isosorbid Dinitrate (5 mg)
Adult:
Immediate release: 5-20 mg PO
q8-12hr initially; maintenance:
10-40 mg PO q8-12hr
 AMOXICILLIN (ADULT)
Ear, Nose, & Throat Infections
Mild to moderate infections
500 mg PO q12hr or 250 mg PO
q8hr for 10-14 days
Severe infections
875 mg PO q12hr or 500 mg PO
q8hr for 10-14 days
Tonsillitis/pharyngitis
Moxatag: 775 mg PO qDay for 10
days, taken within 1 hour after
finishing a meal
Spectrum of action
- and -hemolytic Strep, S
pneumoniae, Staph spp, H influenzae
Genitourinary Tract Infections
Mild to moderate infections
500 mg PO q12hr or 250 mg PO
q8hr
Severe infections
875 mg PO q12hr or 500 mg PO
q8hr
Spectrum of action
E coli, P mirabilis, or E faecalis
Skin & Skin Structure Infections
Mild to moderate infections
500 mg PO q12hr or 250 mg PO
q8hr
Severe infections
875 mg PO q12hr or 500 mg PO
q8hr
Spectrum of action
- and -hemolytic Strep, Staph spp,
E coli
Tonsilitis
775 mg (ER tabs) PO qDay for 10 days
Lower Respiratory Tract Infections
875 mg PO q12hr or 500 mg PO q8hr for
10-14 days
Spectrum of action
- and -hemolytic Strep, S
pneumoniae, Staph spp, H influenzae
Helicobacter Pylori
H pylori infection and active or 1-year
history of duodenal ulcer
Triple therapy
1 g PO q12hr for 14 days with
lansoprazole (30 mg) and
clarithromycin (500 mg)
Dual therapy
1 g PO q8hr for 14 days with
lansoprazole (30 mg) in patients
intolerant of, or resistant to,
clarithromycin
Gonorrhea
Acute, uncomplicated anogenital or urethral
infections
3 g PO once as a single dose
Spectrum of action
N gonorrhoeae
Anthrax
Postexposure inhalational prophylaxis
500 mg PO q8hr
Infective Endocarditis
Prophylaxis
2 g PO 30-60 min before procedure
Dosing considerations
AHA guidelines recommend
prophylaxis only in high-risk patients
undergoing invasive procedures who
have a history of cardiac conditions
that predispose them to a risk of
infection
Lyme Disease (Off-label)
Erythema migrans and other symptoms of
early dissemination
500 mg PO q8hr (depending on size of
patient) for 3-4wk
50 mg/kg/day q8hr in divided doses;
maximum 500 mg/dose
 AMOXICILLIN (PEDIATRIC)
Mild to moderate infections
<3 months: 30 mg/kg/day PO
divided q12hr for 48-72 hours; for
10 days for S pyogenes infections
>3 months and <40 kg: 25
mg/kg/day PO divided q12hr or 20
mg/kg/day PO divided q8hr
>40 kg: 500 mg PO q12hr or 250 mg
PO q8hr for 10-14 days
Severe infections
<3 months: 30 mg/kg/day PO
divided q12hr for 48-72 hours; for
10 days for S pyogenes infections
>3 months and <40 kg: 45
mg/kg/day PO divided q12hr or 40
mg/kg/day PO divided q8hr
>40 kg: 875 mg PO q12hr or 500 mg
PO q8hr for 10-14 days
Tonsillitis/Streptococcal pharyngitis
50 mg/kg PO qDay for 10 days, not
to exceed 1 g/day, OR 25 mg/kg PO
BID for 10 days, not to exceed 500
mg/dose
>12 years: 775 mg (Moxatag) PO
qDay for 10 days, taken within 1
hour after meal (swallow tablet
whole; do not crush or chew)
Spectrum of action
- and -hemolytic Streptococcus, S 50 mg/kg PO 30-60 min before procedure
pneumoniae, Staphylococcus, H
influenzae
Acute Otitis Media
>3 months and <40kg: 80-90 mg/kg/day PO
divided q8-12hr
>40 kg: 500 mg PO q12hr or 250 mg PO
q8hr for 10-14 days
Lower Respiratory Tract Infections
Mild, moderate, or severe infections
<3 months: 30 mg/kg/day PO
divided q12hr for 48-72 hours; for
10 days for S pyogenes infections
>3 months and <40 kg: 45
mg/kg/day PO divided q12hr or 40
mg/kg/day PO divided q8hr
>40kg: 875 mg PO q12hr or 500 mg
PO q8hr for 10-14 days
Spectrum of action
- and -hemolytic Streptococcus, S
pneumoniae, Staphylococcus, H
influenzae
Gonorrhea
Acute, uncomplicated anogenital or urethral
infections
>2 years old to prepuberty: 50 mg/kg PO,
with 25 mg/kg probenecid, once as single
dose
Spectrum of action
N gonorrhoeae
Anthrax
Postexposure inhalational prophylaxis
<40 kg: 15 mg/kg PO q8hr (minimum
recommended dose; should not be <45
mg/kg/day or >q8hr
>40 kg: 500 mg PO q8hr
80 mg/kg/day PO divided q8hr for 4 weeks
(with concomitant vaccine) or for 60 days
(without vaccine)
Infective Endocarditis
Prophylaxis
Dosing considerations
AHA guidelines recommend
prophylaxis only in high-risk patients
undergoing invasive procedures with
history of cardiac conditions that
predispose them to infection
Lyme Disease
Erythema migrans and other symptoms of
early dissemination
<3 months: Safety and efficacy not
established
>3 months and 40 kg: 25-50 mg/kg/day
divided q8hr; not to exceed 500 mg
 CIPROFLOXACIN (ADULT)

Acute Sinusitis
Mild/moderate: 500 mg PO q12hr or 400 mg IV q12hr for 10 days
Bone & Joint Infections
Mild/moderate: 500 mg PO q12hr or 400 mg IV q12hr for 4-6 weeks
Severe/complicated: 750 mg PO q12hr or 400 mg IV q8hr for 4-6 weeks
Chronic Bacterial Prostatitis
Mild/moderate: 500 mg PO q12hr or 400 mg IV q12hr for 28 days
Infectious Diarrhea
Mild/moderate/severe: 500 mg PO q12hr for 5-7 days
Empirical Therapy in Febrile Neutropenic Patients
Severe: 400 mg IV q8hr for 7-14 days
Anthrax Infection
Postexposure therapy
Inhalation (prophylaxis/postexposure): 500 mg PO q12hr or 400 mg IV q12hr for 60 days
Cutaneous: 500 mg PO q12hr or 400 mg IV q12hr for 60 days
Intra-abdominal Infections
Complicated: 500 mg PO q12hr or 400 mg IV q12hr for 7-14 days
Lower Respiratory Tract Infections
Mild/moderate: 500 mg PO q12hr or 400 mg IV q12hr for 7-14 days
Severe/complicated: 750 mg PO q12hr or 400 mg IV q8hr for 7-14 days
Nosocomial Pneumonia
Mild/moderate/severe: 400 mg IV q8hr for 10-14 days
Skin/Skin Structure Infections
Mild/moderate: 500 mg PO q12hr or 400 mg IV q12hr for 7-14 days
Severe/complicated: 750 mg PO q12hr or 400 mg IV q8hr for 7-14 days
Urinary Tract Infections
Acute uncomplicated: Immediate-release, 250 mg PO q12hr for 3 days; extended-release, 500
mg PO q24hr for 3 days
Mild/moderate: 250 mg PO q12hr or 200 mg IV q12hr for 7-14 days
Severe/complicated: 500 mg PO q12hr or 400 mg IV q12hr for 7-14 days
Urethral & Cervical Gonococcal Infections
Uncomplicated: 250-500 mg PO once
Bronchiectasis (Orphan)
Orphan indication sponsor
Aradigm Corporation, 3929 Point Eden Way, Hayward, CA 94545
Noncystic Fibrosis Bronchiectasis (Orphan)
Dry powder for inhalation: Orphan designation for patients with NCFB who suffer from frequent
severe acute pulmonary bacterial exacerbations which lead to further inflammation, airway, and
lung parenchyma damage
Sponsor
Bayer HealthCare
Dosing Modifications
Renal impairment
CrCl >50 mL/min: Dose adjustment not necessary
CrCl 30-50 mL/min: 250-500 mg PO q12hr
CrCl <30 mL/min: Extended-release, 500 mg PO q24hr
CrCl 5-29 mL/min: 250-500 mg PO q18hr or 200-400 mg IV q18-24hr
Some clinicians suggest decreasing dose but not frequency of administration
Hemodialysis: 0.25-0.5 g PO q12hr or 0.2-0.4 g IV q24hr
Peritoneal dialysis: 0.25-0.5 g PO q8hr or 0.2-0.4 g IV q24hr

CIPROFLOXACIN (PEDIATRIC)

Complicated Urinary Tract Infections or Pyelonephritis

<1 year: Safety and efficacy not established

1 year (IV): 6-10 mg/kg q8hr; individual dose not to exceed 400 mg for 10-21 days

1 year (PO): 10-20 mg/kg q12hr; individual dose not to exceed 750 mg q12hr for 10-21 days

Inhalational Anthrax (Off-label)

Postexposure therapy

IV: 10 mg/kg q12hr for 60 days; individual dose not to exceed 400 mg

PO: 15 mg/kg q12hr for 60 days; individual dose not to exceed 500 mg

Change antibiotic to amoxicillin as soon as penicillin susceptibility confirmed

Cystic Fibrosis (Off-label)

PO: 40 mg/kg/day divided q12hr; not to exceed 2 g/day

IV: 20-30 mg/kg/day divided q8-12hr; not to exceed 1.2 g/day

Cholera

Single dose: 30 mg/kg PO

Multiple doses: 30 mg/kg/day PO divided q12hr for 3 days

 CHLORAMPHENICOL (ADULT)

Serious Infections Caused by Susceptible Strains

50 mg/kg/day IV divided q6hr; in exceptional cases, patients with moderately resistant organisms
or severe infections may require increased dosage up to 100 mg/kg/day; decrease these high
doses as soon as possible

Other Indications & Uses

Use only as alternative for treatment of meningitis, typhoid, or rickettsial infection

CHLORAMPHENICOL (PEDIATRIC)
Systemic Infections
Infants and children: As in adults; when adequate cerebrospinal fluid concentrations desired, may
require up to 100 mg/kg/day; however, should reduce dose to 50 mg/kg/day as soon as possible
Infants and children with suspected immature metabolic functions: 25 mg/kg/day divided q6hr
will usually produce therapeutic concentrations of the drug in the blood
Neonates (<28 Days Old)
Loading dose (LdD): 20 mg/kg IV once; give maintenance dose 12 hours after loading dose
Maintenance Dose
<7 days old: 25 mg/kg/day IV q24hr
>7 days old, <2000 g: 25 mg/kg/day IV q24hr
>7 days old, >2000 g: 50 mg/kg/day IV divided q12hr

COTRIMOXAZOLE (ADULT)

Dosing Guidelines for Infections DS tablet: 1 PO q12h for 10-14 days

1-2 DS tablets PO q12-24hr
8-20 mg TMP/kg/day IV q6-12hr
Chronic Bronchitis
Acute exacerbations of chronic bronchitis
due to susceptible strains of Streptococcus
pneumoniae or Haemophilus influenzae
Meningitis, Bacterial
10-20 mg TMP/kg/day IV divided q6-12hr
Pneumocystis (Carinii) Jiroveci
Pneumonia
Documented Pneumocystis jiroveci
pneumonia (PCP); also, prophylaxis against
PCP in individuals who are
immunosuppressed
Prophylaxis
Tablet: 80-160 mg TMP PO qDay or
160 mg TMP 3 times/week on
consecutive or alternate days
Treatment
15-20 mg TMP/kg/day PO/IV
divided q6-8hr
Sepsis
20 mg TMP/kg/day IV divided q6hr
Shigellosis
Enteritis caused by susceptible strains of
Shigella flexneri and S sonnei
DS tablet: 1 tab PO q12hr for 5 days
Alternatively, 8-10 mg TMP/kg/day IV
divided q6-12hr for up to 5 days
Traveler's Diarrhea
Traveler's diarrhea due to susceptible strains
of enterotoxigenic Escherichia coli
DS tablet: 1 tab PO q12hr for 5 days
COTRIMOXAZOLE (PEDIATRIC)
Mild to Moderate Infections
<2 months: Contraindicated
>2 months
8 mg TMP/kg/day PO divided q12hr
Serious Infections
<2 months: Contraindicated
>2 months
15-20 mg TMP/kg qDay PO divided
q6hr
8-12 mg TMP/kg/day IV divided q6-
12hr
Acute Otitis Media
Acute otitis media in pediatric patients due
to susceptible strains of Streptococcus
pneumoniae or Haemophilus influenzae
<2 months: Contraindicated
>2 months: 6-10 mg TMP/kg/day PO
divided q12hr for 10 days
Urinary Tract Infections
UTIs caused by susceptible strains of
Escherichia coli, Klebsiella species,
Enterobacter species, Morganella morganii,
Proteus mirabilis, and Proteus vulgaris
Pyelonephritis: 1 DS tab or 2 regular-
strength tabs PO q12hr x 14 days
Prostatitis: 1 DS tab or 2 regular-strength
tabs PO q12hr x 14 days or 2-3 months if
chronic infection
A 3-day course may be used for acute,
uncomplicated cystitis
Prophylaxis (off-label): Various regimens
exist; may use regular-strength tablet
once/twice per week
Acne Vulgaris (Off-label)
1 DS tab or 1 regular-strength tab PO qDay
or q12hr for up to 18 weeks
Community Acquired Pneumonia
(Off-label)
1 DS tab PO q12hr for 10-14 days
Pneumocystis (Carinii) Jiroveci
Pneumonia
<2 months: Contraindicated
>2 months
Treatment: 15-20 mg TMP/kg/day
PO/IV divided q6-8hr for 21 days
Prophylaxis: 150 mg TMP/m/day
PO divided q12 hr for 3 days/week
on consecutive or alternate days
Shigellosis
<2 months: Contraindicated
>2 months
8 mg TMP/kg/day PO divided q12hr
for 5 days
8-10 mg TMP/kg/day IV divided q6-
12hr for 5 days
Urinary Tract Infection
<2 months: Contraindicated
>2 months
6-12 mg TMP/kg/day PO divided
q12hr for 7-14 days if serious
infection
8-10 mg TMP/kg/day IV divided q6-
12hr for 14 days if serious infection
Prophylaxis: 2 mg TMP/kg/dose
qDay or 5 mg TMP/kg/dose twice
dail
Skin/soft Tissue Infection Due to
Community Acquired MRSA (Off-
label)
4-6 mg TMP/kg/dose PO q12hr for 5-10
days; add beta-lactam antibiotic to regimen
if beta-hemolytic Streptococcuts spp also
suspected

TETRACYCLINE (ADULT)

Chronic Bronchitis, Acute Exacerbation

500 mg PO q6hr
Dosing considerations
Take on empty stomach; do not take with dairy products
Acne
250-500 mg PO q12hr
Ehrlichiosis
500 mg PO q6hr for 7-14 days
Vibrio Cholera
500 mg PO q6hr for 3 days
Malaria, Severe Treatment (Unlabeled)
500 mg PO q6hr for 7 days with quinidine gluconate
Dosing Modifications
Renal impairment
CrCl 50-80 mL/min: dose q8-12hr
CrCl 10-50 mL/min: dose q12-24hr
CrCl <10 mL/min: dose q24hr

TETRACYCLINE (PEDIATRIC)

General Dosing Guidelines

<8 years: Not recommended; tooth discoloration and enamel hypoplasia may occur with use in
young children

>8 years: 25-50 mg/kg/day PO divided q6hr; not to exceed 3 g/day

Malaria, Severe Treatment (Unlabeled)

<8 years: Not recommended; tooth discoloration and enamel hypoplasia may occur with use in
young children

>8 years: 25-50 mg/kg/day PO divided q6hr, not to exceed 250 mg/dose q6hr for 7 days with
quinidine gluconate

Vibrio Cholera

Single dose: 25 mg/kg PO; not to exceed 1 g/dose

Multiple dose: 40 mg/kg/day PO divided q6hr for 3 days; not to exceed 2 g/day
 METRONIDAZOLE (ADULT)
Anaerobic Bacterial Infections and 12 hr after initial dose for maintenance;
Loading dose: 15 mg/kg IV; not to exceed 4
g/day
Maintenance dose: 7.5 mg/kg PO/IV (over 1
h) q6hr x 7-10 days (or 2-3 weeks if severe)
Sexually Transmitted Disease
Prevention following sexual assault
2 g PO as a single dose; 3-drug regimen that
also includes ceftriaxone or cefixime, PLUS
azithromycin or doxycycline (CDC STD
guidelines, 2010)
Bacterial Vaginosis
Nonpregnant women
500 mg PO BID x 7 days, OR
2 g PO qDay single dose, OR
Extended-release: 750 mg PO qDay
x 7 days
Pregnant women
500 mg PO BID x 7 days, OR
250 mg PO TID x 7 days
Colorectal Surgical Infection
Prophylaxis; start after mechanical bowel
preparation the afternoon and evening
before surgery
1 g PO q6-8hr for 3 doses
15 mg/kg IV over 30-60 min; complete
approximately 1 hr before surgery; may
administer 7.5 mg/kg IV over 30-60 min at 6
METRONIDAZOLE (PEDIATRIC)
Neonatal (<28 Days) Anaerobic >2 kg: 30 mg/kg/day IV/PO divided
Infection q12hr
<1.2 kg
7.5 mg/kg IV/PO q48hr
<7 days
1.2-2 kg: 7.5 mg/kg IV/PO qDay
>2 kg: 15 mg/kg/day IV/PO divided
q12hr
>7 days
1.2-2 kg: 15 mg/kg/day IV/PO
divided q12hr
discontinue within 12 hr after surgery
Trichomoniasis
250 mg PO q8hr for 7 days; alternatively,
375 mg PO q12hr for 7 days
2 g PO qDay single dose; alternatively, 1g
PO q12hr for 2 doses
Amebiasis
500-750 mg PO q8hr for 5-10 days
Giardiasis (Off-label)
500 mg PO q12hr for 5-7 days
Gardnerella Infection
Immediate release: 500 mg PO q12hr
Extended-release: 750 mg PO qDay for 7
days; take on empty stomach
Helicobacter Pylori Infection (Off-
label)
250-500 mg PO QID in combination with
tetracycline (500 mg) and bismuth
subsalicylate (525 mg) x 14 days
Nongonococcal Urethritis (Off-label)
2 g PO qDay single dose with erythromycin
(500 mg QID) or erythromycin
ethylsuccinate (800 mg QID) x 7 days
Pelvic Inflammatory Disease (Off-
label)
500 mg PO q12hr for 14 days in conjunction
with ofloxacin or levofloxacin
Infants and Children
30 mg/kg/day PO/IV divided q6hr;
not to exceed 4 g/day
Clostridium Difficile Colitis
30 mg/kg/day IV/PO divided q6hr IV/PO for
7-10 days (American Academy of
Pediatrics)
Amebiasis
35-50 mg/kg PO divided q8hr for 10 days
Giardiasis
15 mg/kg/day IV/PO divided q8hr for 5
days
Trichomoniasis
< 45 kg body weight: 15 mg/kg/day IV/PO
divided q8hr for 7 days; not to exceed 2
g/day
Helicobacter Pylori-Associated
Peptic Ulcer Disease (Off-label)
With amoxicillin and bismuth subsalicylate:
15-20 mg/kg/day PO divided q12hr for 4
weeks
 KETOCONAZOLE (ADULT)

Fungal Infections

200-400 mg/day PO

Dosing Considerations

Do not use tablets as first-line treatment; should be used only when other effective antifungal
therapy is not available or tolerated and the potential benefits are considered to outweigh the
potential of hepatotoxicity

Cushing Syndrome (Off-label)

Used off-label to inhibit steroidogenesis in patients with Cushing syndrome

600-800 mg/day PO

Used rarely and often toxic at doses required to reduce cortisol secretion

Recurrent Tinea Versicolor (Off-label)

400 mg PO monthly

KETOCONAZOLE (PEDIATRIC)

Fungal Infections

<2 years old: Safety and efficacy not established

2 years old: 3.3-6.6 mg/kg/day PO

Mucocutaneous candidiasis in AIDS patients: 5-10 mg/kg/day PO