USULAN PENELITIAN SKIRPSI

PENGARUH PEMBERIAN GLUTATOIN TERHADAP KADAR

DEOXYPYRIDINOLINE TIKUS MODEL (Rattus norvegicus galur Sprague
dawley) POST OVARIEKTOMI DENGAN PERIODONTITIS

Diajukan guna melengkapi tugas akhir dan memenuhi salah satu syarat untuk
menyelesaikan S1 Kedokteran Gigi dan mencapai gelar Sarjana Kedokteran gigi

Oleh:

Hesti Devinta

G1G012031

KEMENTERIAN RISET, TEKNOLOGI, DAN PENDIDIKAN TINGGI

UNIVERSITAS JENDERAL SOEDIRMAN
FAKULTAS KEDOKTERAN
JURUSAN KEDOKTERAN GIGI
PURWOKERTO

2015
i
 DAFTAR ISI

Halaman

HALAMAN JUDUL............................................................................. i

DAFTAR ISI.......................................................................................... ii

DAFTAR GAMBAR ............................................................................ iv

DAFTAR TABEL.................................................................................. v

BAB I PENDAHULUAN...................................................................... 1

A. Latar Belakang......................................................................... 1

B. Rumusan Masalah..................................................................... 3

C. Tujuan Penelitian...................................................................... 3

D. Manfaat Penelitian.................................................................... 4

E. Keaslian Penelitian................................................................... 5

BAB II TINJAUAN PUSTAKA .......................................................... 7

A. Landasan Teori......................................................................... 7

1. Perawatan Ortodonti.................................................................. 7

2. Gingivitis................................................................................... 8

3. Reactive Oxidative Species (ROS)............................................ 12

4. Stress Oksidatif......................................................................... 14

5. Malondialdehyde (MDA).......................................................... 15

ii
 6. Peranan Antioksidan pada Penyakit Periodontal....................... 16

7. Coenzyme q10............................................................................ 17

4. Selenium.................................................................................... 21

B. Kerangka Teori......................................................................... 23

BAB III METODE PENELITIAN...................................................... 20

A. Kerangka Konsep ..................................................................... 24

B. Hipotesis.................................................................................... 24

C. Jenis dan Rancangan Penelitian................................................ 25

D. Lokasi dan Waktu Penelitian..................................................... 26

E. Variabel Penelitian.................................................................... 27

F. Definis Operasional................................................................... 27

G. Populasi dan Sampel Penelitian................................................ 28

H. Sumber Data.............................................................................. 29

I. Instrumen Penelitian.................................................................. 25

J. Cara Pengumpulan Data............................................................ 30

K. Cara Kerja................................................................................. 31

L. Analisis Data............................................................................ 32

M.Jadwal Penelitian....................................................................... 32

DAFTAR PUSTAKA ............................................................................ 33

iii
 DAFTAR GAMBAR

Halaman

Gambar 2.1 Abnormalitas Inti.......................................................................18

Gambar 2.2 Kerangka Teori...........................................................................19

Gambar 3.1 Kerangka Konsep.......................................................................20

Gambar 3.2 Alur Penelitian............................................................................28

iv
 DAFTAR TABEL

Halaman

Tabel 1.1 Keaslian Penelitian

...........................................................................................................

...........................................................................................................

Tabel 2.1 Daftar Bahan Kimia Yang Terkandung Dalam Rokok

...........................................................................................................

...........................................................................................................

Tabel 3.1 Definisi Operasional

...........................................................................................................

...........................................................................................................

22

Tabel 3.2 Jadwal penelitian

v
...........................................................................................................

...........................................................................................................

29

vi