DAFTAR ISI

Halaman

HALAMAN JUDUL ........................................................................................ .i

DAFTAR ISI..................................................................................................... ii

DAFTAR GAMBAR ........................................................................................ vi

DAFTAR SINGKATAN .................................................................................. vii

BAB 1 PENDAHULUAN ................................................................................ 1

1.1 Latar Belakang .................................................................................... 1

1.2 Rumusan Masalah ............................................................................... 4

1.3 Tujuan Penelitian ............................................................................... 4

1.3.1 Tujuan Umum ........................................................................... 4

1.3.2 Tujuan Khusus .......................................................................... 4

1.4 Manfaat Penelitian .............................................................................. 5

1.4.1 Manfaat Akademik ................................................................... 5

1.4.2 Manfaat Klinis .......................................................................... 5

1.4.3 Manfaat Masyarakat ................................................................. 5

BAB 2 TINJAUAN PUSTAKA....................................................................... 6

2.1 Kelor (Moringa Oleifera).................................................................... 6

2.1.1 Taksonomi.................................................................................. 6

2.1.2 Morfologi ................................................................................... 6

2.1.3 Habitat dan Distribusi ................................................................ 7

2.1.4 Kandungan ................................................................................. 7

2.1.5 Manfaat ...................................................................................... 9

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 2.1.6 Pengaruh Daun Kelor terhadap Perlemakan Hati ...................... 9

2.2 Hati ...................................................................................................... 10

2.2.1 Anatomi Hati .............................................................................. 10

2.2.2 Histologi Hati ............................................................................. 12

2.2.3 Fisiologi Hati ............................................................................. 13

2.3 Metabolisme Lemak ............................................................................ 15

2.3.1 Metabolisme lipoprotein ............................................................. 16

2.4 Perlemakan Hati non Alkoholik.......................................................... 20

2.4.1 Definisi ....................................................................................... 20

2.4.2 Patogenesis ................................................................................. 20

2.4.3 Faktor Risiko .............................................................................. 22

2.4.4 Tanda dan Gejala ....................................................................... 23

2.4.5 Gambaran Histopatologi ............................................................ 23

2.5 Dislipidemia ........................................................................................ 25

2.5.1 Definisi ....................................................................................... 25

2.5.2 Komposisi Lipoprotein .............................................................. 25

2.6 Tikus Putih .......................................................................................... 26

2.6.1 Hepar tikus ................................................................................. 27

BAB 3 KERANGKA KONSEP DAN HIPOTESIS ...................................... 29

3.1 Kerangka Konsep ................................................................................ 29

3.2 Hipotesis ............................................................................................. 31

BAB 4 METODE PENELITIAN .................................................................... 31

4.1 Rancangan Penelitian .......................................................................... 31

4.2 Lokasi dan Waktu Penelitian .............................................................. 31

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4.3 Populasi dan Sampel ........................................................................... 31

4.3.1 Populasi ...................................................................................... 31

4.3.2 Sampel........................................................................................ 31

4.3.3 Besar Sampel ............................................................................. 31

4.3.4 Teknik Pengambilan Sampel ..................................................... 32

4.3.5 Karakteristik Sampel Penelitian ................................................. 33

4.3.6 Variabel Penelitian ..................................................................... 33

4.3.6.1 Variabel Bebas ............................................................... 33

4.3.6.2 Variabel Tergantung ...................................................... 33

4.3.7 Definisi Operasional .................................................................. 34

4.4 Alat dan Bahan Penelitian ................................................................... 35

4.4.1 Alat pembuatan ekstrak daun kelor (Moringa oleifera.)............ 35

4.4.2 Alat dan bahan pemeliharaan tikus ............................................ 35

4.4.3 Alat dan bahan bedah tikus ........................................................ 36

4.4.4 Alat lain ...................................................................................... 36

4.5 Prosedur Penelitian ............................................................................. 36

4.5.1 Adaptasi ..................................................................................... 36

4.5.2 Pembagian kelompok tikus ........................................................ 37

4.5.3 Pemberian diet hiperkolestrolemia............................................. 37

4.5.4 Dasar Penentuan Dosis .............................................................. 38

4.5.5 Cara pembuatan ekstrak daun kelor ........................................... 38

4.5.6 Proses anastesi dan pembedahan hewan coba ........................... 39

4.5.7 Pembuatan Sediaan Histopatologi Hepar ................................... 40

4.5.8 Pengamatan Hasil ....................................................................... 42

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 4.6 Alur Penelitian .................................................................................... 43

4.7 Analisis Data ....................................................................................... 44

DAFTAR PUSTAKA ....................................................................................... 45