DAFTAR ISI

HALAMAN JUDUL ........................................................................................... i

HALAMAN PENGESAHAN ............................................................................ ii
PERNYATAAN ................................................................................................ iii
KATA PENGANTAR ....................................................................................... iv
DAFTAR ISI .................................................................................................... vii
DAFTAR TABEL ............................................................................................ ix
DAFTAR GAMBAR ........................................................................................ xi
DAFTAR LAMPIRAN .................................................................................... xii
DAFTAR SINGKATAN ................................................................................ xiii
INTISARI ........................................................................................................ xiv
ABSTRACT ..................................................................................................... xv
BAB I. PENDAHULUAN
A. Latar Belakang...........................................................................1
B. Rumusan Masalah .....................................................................4
C. Tujuan Penelitian .......................................................................4
D. Manfaat Penelitian ....................................................................4
E. Keaslian Penelitian ....................................................................4
BAB II. TINJAUAN PUSTAKA
A. Keganasan Limfoma ................................................................. 7
B. Neutropenia dan Febrile Neutropenia .................................... 18
C. Filgrastim ............................................................................... 27
D. Cara Penetapan Absolute Neutrophil Count (ANC) .............. 39
E. Landasan Teori ....................................................................... 41
F. Kerangka Konsep ................................................................... 44
G. Hipotesis ................................................................................. 44
BAB III. METODOLOGI PENELITIAN
A. Jenis dan Rancangan Penelitian.............................................. 45
B. Waktu dan Tempat Penelitian ................................................ 45
C. Subjek Penelitian ................................................................... 45
D. Variabel Penelitian.................................................................. 47

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 E. Definisi Operasional .............................................................. 48
F. Alat dan Bahan ....................................................................... 49
G. Jalan Penelitian ...................................................................... 49
H. Pengolahan dan Analisis Data ................................................ 52
BAB IV HASIL PENELITIAN DAN PEMBAHASAN
A. Karakteristik Subjek Penelitian................................................. 54
1. Karakteristik pemakaian filgrastim pada masing-masing
variabel confounder (perancu) ............................................. 57
2. Baseline ANC masing-masing filgrastim ............................ 63
3. Data waktu ANC recovery................................................... 63
B. Penentuan Faktor-Faktor yang Berpengaruh Pada Waktu
ANC Recovery .......................................................................... 64
1. Jenis filgrastim dengan waktu ANC recovery ..................... 65
2. Jenis kelamin dengan waktu ANC recovery........................ 68
3. Umur dengan waktu ANC recovery .................................... 70
4. Body Mass Index dengan waktu ANC recovery ................. 73
5. Jenis kanker dengan waktu ANC recovery.......................... 75
6. Jenis regimen dengan waktu ANC recovery........................ 76
7. Siklus kemoterapi dengan waktu ANC recovery................. 78
8. Episode neutropenia dengan waktu ANC recovery............. 80
9. Grade neutropenia dengan waktu ANC recovery................ 81
C. Perbandingan Efektivitas Filgrastim ......................................... 86
D. Data Pengamatan Lebih Dari 24 Jam Post Suntik Terakhir ..... 98
E. Keterbatasan Penelitian .......................................................... 101
BAB V. KESIMPULAN DAN SARAN
A. Kesimpulan ............................................................................. 102
B. Saran........................................................................................ 102
DAFTAR PUSTAKA ..................................................................................... 104
LAMPIRAN .................................................................................................. 111
RINGKASAN TESIS ..................................................................................... 163
SUMMARY.................................................................................................... 164
NASKAH PUBLIKASI.................................................................................. 165

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