i

DAFTAR ISI

DAFTAR ISI ....................................................................................................... i

DAFTAR TABEL ............................................................................................... iv
DAFTAR GAMBAR .......................................................................................... v

BAB 1 PENDAHULUAN ................................................................................... 1

1.1 Latar Belakang Masalah .................................................................. 1
1.2 Rumusan Masalah ............................................................................ 6
1.4 Tujuan Penelitian ............................................................................. 6
1.4.1 Tujuan Umum ......................................................................... 6
1.4.2 Tujuan Khusus ........................................................................ 6

1.5 Manfaat Penelitian........................................................................... 6

1.5.1 Manfaat Akademis ................................................................... 6
1.5.2 Manfaat Pelayanan Masyarakat ............................................... 7
1.5.3 Pengembangan Penelitian ....................................................... 7

BAB 2 LANDASAN TEORI ............................................................................. 8

2.1 Definisi .............................................................................................. 8
2.2 Patofisiologi Nyeri .......................................................................... 9
2.3 Pembagian Nyeri .............................................................................. 13
2.3.1 Mekanisme Nyeri Kronik Pasca Operasi ................................. 15
2.4 Matrix Metalloproteinasi (MMP) .................................................. 20
2.4.1 Regulasi MMP ......................................................................... 22
2.4.2 MMP-9 dan MMP-2 Pada Penyakit Saraf ............................... 22
2.4.3 MMP-9 dan MMP-2 Pada Nyeri Neuropatik .......................... 24
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2.5 Kerangka Teori .............................................................................. 28

2.6 Hipotesis .......................................................................................... 29
2.7 Kerangka Konsep .......................................................................... 29
BAB 3 METODE PENELITIAN ...................................................................... 30
3.1 Rancangan Penelitian ...................................................................... 30
3.2 Tempat dan Waktu Penelitian ........................................................ 30
3.3 Subjek Penelitian ............................................................................. 30
3.3.1 Populasi Sasaran .................................................................... 30
3.3.2 Populasi Terjangkau .............................................................. 31
3.4 Perkiraan Besar Sampel .................................................................. 31
3.5 Kriteria Inklusi Eksklusi ................................................................ 32
3.5.1 Kriteria Inklusi ...................................................................... 32
3.5.2 Kriteria Eksklusi .................................................................... 32
3.6 Variabel Penelitian ......................................................................... 32
3.6.1 Variable Dependen ................................................................ 32
3.6.2 Variable Indenpenden ........................................................... 32
3.7 Definisi Operasional ........................................................................ 33
3.8 Pelaksanaan Penelitian .................................................................... 34
DAFTAR PUSTAKA ......................................................................................... 52
LAMPIRAN
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DAFTAR TABEL

Tabel 1. Jenis Serabut Saraf Yang Ada Di Perifer ......................................... 11

Tabel 2. Perbedaan Nyeri Nosiseptif Dengan Neuropatik ............................. 14
Tabel 3. Faktor Predisposisi Nyeri Kronik Pasca Operasi ............................ 15
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DAFTAR GAMBAR

Gambar 1. Struktur Protein Secara Umum Dari Seluruh MMP ................. 21

Gambar 2. Kerangka Teori ............................................................................... 28
Gambar 3. Kerangka Konsep ............................................................................ 29