Artikel Fenil Tiourea PDF
Artikel Fenil Tiourea PDF
Abstract
Thiourea is one of the compounds that are useful in studies of new drug discovery. Some
thiourea derivatives have potent pharmacological activity as anticancer [1-9].
1-benzoyl-3–Phenylthiourea compound has been synthesized through acylation reaction
between benzoyl chloride with 1-Phenylthiourea using tetrahydrofuran as solvent and triethylamine
as catalyst by reflux and stirring for 6 hours . Synthesis results obtained percentage is 89 % . The
purity of the synthesis results indicated the presence of a single stain on TLC and narrow melting
range .
From the characterization by UV spectrophotometry , infrared spectroscopy, 1-HNMR
spectroscopy and mass spectroscopy can be concluded that the resulting compound is 1-benzoyl-3-
phenylthiourea structure. From the in vitro test obstained IC-50 of 1-benzoyl-3-phenyl thiourea on
HeLa cells at 702 g/ml, and IC-50 on MCF-7 cells at 398 g/ml.
1 140-142 NH NH
2 140-142
3 140-142
Gambar 1. Spektrum Ultra Violet 1-feniltiourea Gambar 3. Hasil Spektrum Infra merah
dalam pelarut etanol (λmaks = 288,5 nm) Senyawa Hasil Sintesis
Tabel 5. Bilangan Gelombang Spektrun Infra teridentifikasi pada senyawa tersebut
Merah Senyawa Hasil Sintesis diantaranya gugus –NH, C=O dan C=S yang
Gugus Bilangan Gelombang Hasil terbukti ada pada senyawa hasil sintesis.
fungsi sintesis (cm-1) Dengan demikian diperkirakan 1-benzoil-3-
3370,96 feniltiourea terbentuk dari hasil sintesis.
Ulur –NH
3313,11
Ulur C=O 1673,91 Hasil Spektrofotometri Resonansi Magnet
Ulur C=S 1153,2 Inti (H-NMR)
Identifikasi lainnya dilakukan
Dari spektrum pada Gambar 4.3 menggunakan Spektrofotometri Resonansi
teridentifikasi gugus-gugus fungsional utama Magnet Proton (H-NMR).
yang terdapat pada senyawa 1-benzoil-3-
feniltiourea. Gugus fungsional yang
f h
O S
b f d c g h b
c g
N N
H H f
a e
d b
a e