soal no 1

waktu c log C ln c
1 10 96.0 1.982271 4.564348
2 20 89.0 1.94939 4.488636
3 40 73.0 1.863323 4.290459
4 60 57.0 1.755875 4.043051
5 90 34.0 1.531479 3.526361 HAL 69-71
6 120 10.0 1 2.302585
7 130 2.5 0.39794 0.916291
Dit :. orde, 2, t1/2, Ao, Pers regresi

pers c pers ln pers log

120.0 6
100.0 2 pers
4 pers ln
f(x)
80.0= − 0.783227848101266 x + 104.231012658228 log
R² = 0.99993410630465
60.0 2 1
40.0 0
20.0 0
0
0
20
0.0

0
0 20 40 60 80 100 120 140
DIK : BB- 50, DOSIS 6 MG/KG
f(x)
10 = − 0.0739525789896369 x + 0.933167494168769
T C LOG C R² = 0.999999444180398
1 0.25 8.21 0.914343
2 0.5 7.87 0.895975
3 1 7.23 0.859138
4 3 5.15 0.711807
5 6 3.09 0.489958
6 12 1.11 0.045323
7 18 0.4 -0.39794
DIT : VD,K,T1/2
DURASI T 99,9%
JK DOSISNYA2X BRP T KERJA
MEC=2UG/ML
1
0 2 4 6 8
C
10 12 14 16

JAWAB: pers reg : y=-0.074 x +0.933

10
a Persamaan farmakokinetik log C = log Co - ke /2,303 .t
log Cp= - 0.074 t + 0.933 f(x) = − 0.450139846619836 x + 7.34331410710833
Jadi Co = 0.0933 R² = 0.892062342127939
k/2303 = 0.074 k = -2.302x 0.074 0.170422

b log Cp= - 0.074 t + 0.933 log Co =0.933…

log 0.1%.Co= -0.074 xt +0.933 Co=8.59 C
log( 0.1/100 x 8.59)=-(0.074t +0.933) Linear (C)
log0.1/100 =0.74 t + log 100 1
-5
t= -6.756757
 1

0.1
9 0 2 4 6 8 10 12 14 16 18 20
8
7
f(x) = − 0.450139846619836 x + 7.34331410710833
6 R² = 0.892062342127939
C
5
Linear (C)
4
LOG
3
Linear (LOG)
2
1
0 f(x) = − 0.0739525789896369 x + 0.933167494168769
R² = 0.999999444180398
-1 0 2 4 6 8 10 12 14 16 18 20
 10

167494168769

C
loC
Linear (loC)
Linear (loC) 0.1
0 2 4 6 8 10

C
10 12 14 16 18 20

19836 x + 7.34331410710833
39

C
Linear (C)
8 10 12 14 16 18 20
 1
2
C 3
4
5
6
7
8
C
9
10

10000

4 6 8 10 12 14 16 18 20 1000

100

10

1
0

0.1

0.01
 5000
2000
1000
100
10
4
1
0.5
0.1
0.01

10000

1000

100

Column
10
A

1
0 2 4 6 8 10 12

0.1

0.01
 Column AD
A

12
 S eorang pasien memerlukan infus asam aminocaproat selama 24 jam

dengan kecepatan 1 g/jam. Konsentrasi obat setiap saat dimonitor yang hasilnya sbb :
Berapakah konsentrasi tunak obat tsb, hitunglah nilai ke dan klirennya

T( jam) : 2 4 6 8 12 16 20 24
Cp(μ/ml): 37 65 83 97 113 122 128 130
log Cp 1.568201724067 1.813 1.9191 1.987 2.0531 2.086 2.107 2.11394

Soal no 1
1000

Soal no 1
100

10
0 5 10 15 20 25 30

Prokainamid
100

2 Suatu infus prokain amid diberikan selama 8 jam dan konsentrasinya ditentukan setiap saat sbb : Prokainamid
T(jam) : 0 2 4 6 8
10
Cp(μ/ml): 0 37 65 83 97
Hitunglah : Ke, t½, dan konsentrasi tunak
Jawab
1
0 1 2 3 4 5 6 7 8 9

KERJAKAN DIRUMAH HAL 215-216. DAN KERJAKAN/PELAJARI CONTOH2 SOAL PADA BAB INFUS
CONTOH HAL 198, tabel 8.5

t(jam) 0 1 2 3 4 5 6 7 8 9 10
Cpstl infus 0 1.81 3.3 2.7 2.21 1.81 1.48 1.21 0.99 0.81 0.67
Cpinfus 2 0
Ctotal 0 1.81 3.3 2.7 2.21 1.81 1.48 1.21 0.99 0.81 0.67
10
 1
0 2 4 6 8 10 12 14 16

198 DIK : INFUS 1 40mh selama 2 jam. Infus ke 2 40mg selama 2jam pd jam ke 10
Ditanya : Cp 2jam stl infus 1
Cp stl 5 jam infus ke2 dimulai
kainamid

Prokainamid

7 8 9

11 12 13 14 15
0.55 0.45 0.37 0.3 0.25
1.81 3.3 2.7 2.21 1.81
2.36 3.74 3.07 2.51 2.06

INFUS 1
INFUS 2
TOTAL
 INFUS 1
INFUS 2
TOTAL

12 14 16

k=0,2jam-1 Vd=10ml
contoh soal tabel 7.1
Dik :
t(jam) 0 1 2 3 4 5 6 7 8 9
Cp 0.00 3.13 4.93 5.86 6.25 6.28 6.11 5.81 5.45 5.66
Dit : Ke,ka, persamaan
Jawab
t(jam) 0 1 2 3 4 5 6 7 8 9
Cp 0.00 3.13 4.93 5.86 6.25 6.28 6.11 5.81 5.45 5.06
log Cp log0.0 0.4955 0.6928 0.768 0.7959 0.798 0.786 0.7642 0.736 0.704
LOG Cpe 1.13 1.086 1.042 0.998 0.954 0.91 0.866 0.822 0.778 0.734
Cpe=anti Log Cpe 13.49 12.19 11.015
1.5
Cpe-Cp 13.49 9.06 6.09
log Cpe-Cp 1.13 0.9571 0.7843 Y=-0.172X+1.13
1 f(x)
f(x)= =− −0.172855681300757
0.044 x + 1.13 x+
R²R²= =0.999999995029981
1
0.5

0
hal 182 no 1 0 10 20 30
Dik : -0.5
t(jam) 0.25 0.50 0.75 1.00 2.00 4.00 6.00 10.00 14.00 20.00
Cp 2.85 5.43 7.75 9.84 16.20 22.15 23.01 19.09
-1 13.90 7.97
Dit : Ke,ka, persamaan
Jawab -1.5
t(jam) 0.25 0.50 0.75 1.00 2.00 4.00 6.00 10.00 14.00 20.00
Cp 2.85 5.43 7.75 9.84 16.20 22.15 23.01 19.09 13.90 7.97
log Cp 0.455 0.7348 0.8893 0.993 1.2095 1.3454 1.3619 1.2808 1.143 0.901
LOG CP 1.658 1.648 1.6385 1.629 1.591 1.515 1.439 1.281 1.143 0.902
Cpe 45.45 44.463 43.501 42.56
Cpe-Cp 42.60 39.03 35.75 32.72
log Cpe-Cp 1.629 1.5914 1.5533 1.515 1.3632 1.059 0.755 0.147 -0.461 -1.373

1.5 f(x) = − 0.152168652531317 x + 1.66744962766551

R² = 0.999997600815061
1 f(x) = − 0.0381182858926429 x + 1.66
R² = 0.998264472374978
0.5

0
0.00 5.00 10.00 15.00 20.00
-0.5

-1

-1.5

-2
-1.5

-2
 10 12 14 16 18 24 28 32 36 48
4.66 3.90 3.24 2.67 2.19 1.20 0.81 0.54 0.36 0.10

10 12 14 16 18 24 28 32 36 48
4.66 3.90 3.24 2.67 2.19 1.20 0.81 0.54 0.36 0.10
0.668 0.591 0.511 0.427 0.34 0.079 -0.09 -0.27 -0.44 -1
0.69 0.602 0.514 0.426 0.338 0.074 -0.1 -0.28 -0.45 -0.982 Y=-0.44X +1.13 β=-0.044 Ke=

Y=-0.172X+1.13 α=-0.172 Ka=

(x)
f(x)= =− −0.172855681300757
0.044 x + 1.13 x + 1.12999296438492
²R²= =0.999999995029981
1 1.5

PROFIL
EL 1 f(x) = − 0.172855681300757
0.044 x + 1.13 x + 1.12999296438492
Linear (EL) R² = 0.999999995029981
1
10 20 30 40 ABS
50 60
Linear (ABS) 0.5
profil
ELIMINASI
0 Linear (ELIMINASI)
0 10 20 30 ABS
40 50 60
Linear (ABS)
-0.5

-1
Y=-0.038X+1.667

-1.5
y=-0,152x+1.667

317 x + 1.66744962766551
0.0381182858926429 x + 1.66749454310672
98264472374978 PROFIL
F. ELIMIN
Linear (F.
ELIMIN)
00 15.00 20.00 FS ELIM
25.002
fs absorpsi
Linear (fs
absorpsi)
abs lanju-
tan
 0

0.101332 0.909091
550
0.396116
contoh soal : H: 79, soal 2

Diketahui : diberikan secara iv 100mg pada pria sehat 75kg

t (jam) 0.25 0.50 1.00 1.50 2.00 4.00 8.00 12.00

Cp(ug/ml) 43.00 32.00 20.00 14.00 11.00 6.50 2.80 1.20
Ditanya parameter farmakokinetik obat tsb
Jawab
t (jam) 0.25 0.50 1.00 1.50 2.00 4.00 8.00 12.00
Cp(ug/ml) 43.00 32.00 20.00 14.00 11.00 6.50 2.80 1.20

log Cp 1.63 1.51 1.30 1.15 1.04 0.81 0.45 0.08

Fs eliminasi y=-0.091 x + 1.177 1.1543 1.132 1.086 1.0405 0.995 3.786 2.80 1.20
log Cp' 1.1543 1.132 1.086 1.0405 0.995 0.813 0.45 0.079
Cp'
cp-cp' 41.85 30.87 18.91 12.96 10.01
pers dist : log (Cp-Cp')= -0.435x +1.657 1.6217 1.49 1.2768 1.1126 1 -0.083 -1.82 -3.563

k = ab(A+B)/Ab +Ba
k12= AB(b-a)2
k21= AB(b-a)2 /(A+B)(Ab+Ba)

soal no 2
t (jam) 0.17 0.33 0.5 0.67 1 1.5 2 3
Cp(ug/ml) 36.2 34 27 23 20.8 17.8 16.5 13.9
LOG Cp 1.5587 1.531 1.4314 1.3617 1.318 1.25 1.22 1.143
Log Cp' 1.1344 1.129 1.1235 1.1179 1.107 1.091 1.07 1.041
Cp' 13.627 13.46 13.289 13.119 12.79 12.32 11.9 10.99
Cp-Cp' 22.573 20.54 13.711 9.8813 8.006 5.483 4.64 2.91
log CP-CP' 1.3536 1.313 1.1371 0.9948 0.903 0.739 0.67 0.464
1.8
1.6
1.4
1.2
1 f(x) = − 0.033952115522621 x + 1.14151692927079
R² = 0.998047179259461
0.8 f(x) = − 0.207113760732391 x + 1.08270797397217
80 R² = 0.992449206157107
0.6
70 0.4
0.2
60
0
2 komp
50 0 5 10 15 20
eliminasi
Linear (eliminasi)
40
E2
30 Linear (E2)
EA
20 Linear (EA)

f(x) = − 1.15496416043923 x + 15.0070230288242

 60
2 komp
50 eliminasi
Linear (eliminasi)
40
E2
30 Linear (E2)
EA
20 Linear (EA)

10 f(x) = − 1.15496416043923 x + 15.0070230288242

R² = 0.998735869160421f(x) = − 1.37
f(x) =x−+1.15
16.27x + 14.95
R² = 0.971078228476821
R² = 0.988785046728972
Soal no 1 hal 102 0
t (jam) 0 1 2 03 0.254 0.55 0.75
6 71 1.5
8 2 2.5
Cp(ug/ml) 70 53.8 43.3 35 29.1 21.2 17,0 14.3
Ditanya parameter farmakokinetik obat tsb:
Jawab
t (jam) 0 0.25 0.5 0.75 1 1.5 2 2.5
Cp(ug/ml) 70 53.8 43.3 35 29.1 21.2 17 14.3
Cp' 14.95 14.68 14.4 14.125 13.85 13.3 12.8 12.2
LOG Cp 1.8451 1.731 1.6365 1.5441 1.464 1.326 1.23 1.155
Log Cp' 1.1746 1.167 1.1584 1.15 1.141 1.124 1.11 1.086
Log Cp-log Cp' 0.6705 0.564 0.4781 0.3941 0.322 0.202 0.12 0.069
Cp-Cp'
 contoh soal : H: 79, soal 2

Diketahui : diberikan secara iv 100mg pada pria sehat 75kg

16.00 t (jam) 0.25 0.50 1.00

0.52 3.00 Cp(ug/ml) 43.00 32.00 20.00
Ditanya parameter farmakokinetik obat tsb
2.00 Jawab
16.00 f(x) = − 0.3558648022 x t (jam) 0.25 0.50 1.00
1.00 + 1.6738091635
0.52 Cp(ug/ml) 43.00 32.00 20.00
R² = 0.980007817643874
0.00 f(x) = − 0.091394336 x
-0.28 0.00 5.00 10.00 + 1.1775129052
15.00 20.00 log Cp 1.633468456 1.505 1.301
R² = 0.99998564066679
0.52 -1.00 log Cpe=Log Cp2 1.15425 1.1315 1.086
-0.284 Cp2 14.26428476 13.5363 12.1899
-2.00
Cp1-Cp2 28.74 18.46 7.81
-3.00 log(Cp1-Cp2) 1.458 1.266 0.893
-5.303
-4.00 2

Profil
k = ab(A+B)/Ab +Ba
-5.00
Eliminasi k12= AB(b-a)2
1.5
-6.00 Linear (Eliminasi) k21= AB(b-a)2 /(A+B)(Ab+Ba) f(x) = − 0.80
0.75
R² = 0.9990
0.9999

1 f(x) = − 0.09
R² = 0.9999
f(x) = − 0
4 6 7.7 18 23 R² = 0.9
12 8.7 7.7 3.2 2.4 0.5
1.079 0.94 0.89 0.51 0.38
1.008 0.94 0.89 0.5 0.38 Y=-0.033X+1.14
10.19 8.71 7.76 3.16 2.4 0
1.814 -0.01 -0.06 0.04 0 0.00 2.00
0.259
-0.5

PROFIL
x + 1.14151692927079
FA EL
91 x + 1.08270797397217 Linear (FA EL) 100
fs dis 1
Linear (fs dis 1)

PROFIL
FS EL
2 komp
15 20 25 10 Linear (FS EL)
eliminasi
Linear (eliminasi) f(x) = − 0.382288688878625 x + 10.7277978204152
R² = 0.976251568397182
E2
Linear (E2)
EA
Linear (EA)
1
 FS EL
2 komp
eliminasi 10 Linear (FS EL)
Linear (eliminasi) f(x) = − 0.382288688878625 x + 10.7277978204152
R² = 0.976251568397182
E2
Linear (E2)
EA
Linear (EA)
1
0 5 10 15 20 25
100
3 4 5 6 7 2
12.6 10.5 9 8 7

3 4 5 6 7
12.6 10.5 9 8 7
11.65 10.5 9 8 7
1.1 1.021 0.95 0.9 0.85 Persamaan Fs Eliminasi : y=-1.15x+14,95
1.066 1.021 0.95 0.9 0.85 log Cp = -1,15 t +14.95
0.034 0 0 0 0
pada pria sehat 75kg

1.50 2.00 4.00 8.00 12.00 16.00

14.00 11.00 6.50 2.80 1.20 0.52

1.50 2.00 4.00 8.00 12.00 16.00 tan a =-0.091 = -ke/2.303

14.00 11.00 6.50 2.80 1.20 0.52

1.146 1.041 0.813 0.447 0.079 -0.284 Y=-0.091+1.177

1.0405 0.995 0.813 0.447 0.079 -0.284
10.9774 9.88553 6.5012969 2.799 1.199 0.52
3.02 1.11 0.00 0.00 0.00 0.00
0.480 0.047

1.5
f(x) = − 0.803395443353994
0.753349334630186 x + 1.67253409159276
1.64525295944959 PROFIL
R² = 0.999952022247765
0.999044432677087
FS ELIMINASI
1 f(x) = − 0.0913946806237983 x + 1.17753992202521 Linear (FS ELIMINASI)
R² = 0.999997370168909 FS DIS
f(x) = − 0.84558880411805 x + 1.741751091252 Linear (FS DIS)
R² = 0.999793810933704
FD3
0.5 Linear (FD3)
FD 4
Linear (FD 4)
0
0.00 2.00 4.00 6.00 8.00 10.00 12.00 14.00 16.00 18.00

-0.5

4152
4152
 PROFIL
100.00

10.00
PROFIL

1.00

0.10

20 0
00

10 0
15 0

0
0
.0
.0
.0
0.
5.