Stefanus Gunawan
Infeksius A E
Transmisi
Enterik
Transmisi
Serum B D C Parenteral
F, G, TTV
? lain2
Hepatitis
proses radang/inflamasi hati
Berbagai penyebab:
Obat-obatan
Toksin
Alkohol
Infeksi virus (A, B, C, D, E, dll)
Infeksi lain2 (parasit, bakteri)
Faktor fisik
Virus Hepatitis A
Virus Hepatitis A
Transmisi Fekal-oral
Titre ALT
Fecal
HAV
IgM anti-HAV
0 1 2 3 4 5 6 1 2
2 4
Months after exposure
Diagnosis Laboratorik
HBcAg
HBeAg
Infeksi Virus Hepatitis B
Transmisi Bloodborne
Subclinical cases transmit
Rendah/
Tinggi Moderat Tak terdeteksi
darah semen urin
serum cairan vagina feses
eksudat luka saliva keringat
air mata
ASI
Transmisi Hepatitis B Perinatal*
Hepatitis Fulminan
Sirosis Hepatis
Karsinoma Hepatoselular
Kematian
Acute Hepatitis B Virus Infection with Recovery
Typical Serologic Course
Symptoms
HBeAg anti-HBe
Total anti-HBc
Titre
0 4 8 12 16 20 24 28 32 36 52 100
IgM anti-HBc
0 4 8 12 16 20 24 28 32 36 52 Years
Weeks after Exposure
Outcome of Hepatitis B Virus Infection
100 by Age at Infection 100
80
Chronic Infection (%)
80
20 20
Symptomatic Infection
0 0
Birth 1-6 months 7-12 months 1-4 years Older Children
and Adults
Age at Infection
Diagnosis
Jadwal 3 Dosis
Dosis (mcg)
Bayi & 0.5 mL (10)
anak <11 tahun
Dosis Interval
Usia lazim Minimum
Primer 1
Primer 2 0-2 bulan --
Primer 3 1- 4 bulan 4 minggu
6-18 bulan 8 minggu*
5 3
cor E1 E2 NS NS NS NS
e 2 3 4 5
hypervariable
region
Hepatitis C - Clinical Features
Titre
ALT
Normal
0 1 2 3 4 5 6 1 2 3 4
Month Years
s Time after
Exposure
Risk Factors Associated
with Transmission of HCV
RNA
Hepatitis D - Clinical Features
Coinfection
severe acute disease.
low risk of chronic infection.
Superinfection
usually develop chronic HDV infection.
high risk of severe chronic liver disease.
may present as an acute hepatitis.
Hepatitis D Virus Modes
of Transmission
Percutanous exposures
injecting drug use
Permucosal exposures
sex contact
HBV - HDV Coinfection
Typical Serologic Course
Symptoms
ALT Elevated
Titre
anti-HBs
IgM anti-HDV
HDV RNA
HBsAg
Total anti-HDV
ALT Elevated
Titre
anti-HBs
IgM anti-HDV
HDV RNA
HBsAg
Total anti-HDV
Symptoms
Total anti-HDV
ALT
Titre
HDV RNA
HBsAg
IgM anti-HDV
Virus in stool
0 1 2 3 4 5 6 7 8 9 1 1 1 1
0 1 2 3
Weeks after Exposure
Hepatitis E Virus Infection
Typical Serologic Course
Symptoms
Virus in stool
0 1 2 3 4 5 6 7 8 9 1 1 1 1
0 1 2 3
Weeks after Exposure
Hepatitis E -
Epidemiologic Features