ANALGESIK

APRIANI SIMBI HALIMAH

P17111171004)
 Pengertian Analgesik

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Analgesik adalah obat-obat yang dapat
mengurangi atau menghilangkan rasa nyeri tanpa
menghilangkan kesadaran .Pada umumnya analgesik
efektif untuk menghilangkan sakit kepala, nyeri otot,
nyeri sendi dan nyeri lainnya.
Misalnya nyeri pasca bedah, pasca bersalin,
disminore(nyeri haid) dan pada nyeri hebat yang sulit
dikendalikan.Hampir semua analgesik memiliki efek
antipiretik,dan efek antiinflamasi.
Analgesik antiinflamasi diduga bekerja berdasarkan penghambatan
sintesis prostaglandin(penyebab rasa nyeri). Rasa nyeri sendiri dapat
dibedakan dalam 3 kategori:
 Nyeri ringan
Contoh = sakit gigi,sakit kepala, nyeri otot, nyeri haid
dapat diatasi dengan asetosal,paracetamol,bahkan
placebo.
 Nyeri sedang
Contoh = migran,sakit punggung, rheumatik memerlukan
analgesik kuat.
 Nyeri hebat
Contoh = kolik/kejang usus harus diatasi dengan
analgesik sentral atau analgesik narkotik.
 Macam-Macam
Golongan Obat Analgesik
1. Analgesik narkotik (analgesik sentral)

Analgesik narkotik bekerja di SSP (susunan saraf pusat),

memiliki daya penghalang nyeri yang hebat sekali. Dalam
dosis besar dapat bersifat depresan umum (mengurangi
kesadaran) mempunyai efek samping menimbulkan rasa
nyaman.Hampir semua perasaan tidak nyaman dapat
dihilangkan oleh analgesik narkotik kecuali sensasi kulit.
 Mekanisme aksi obat analgesik
narkotik

Mekanisme aksi obat golongan ini adalah

dengan menghambat adenilat siklase dari
neuron, sehingga terjadi penghambatan
sintesis c-AMP (siklikAdenosin Mono
Phosphat), selanjutnya menyebabkan
perubahan keseimbangan antara neuron
noradrenergik, serotonik dan kolinergik.
 obat analgesik narkotik
Mefiridin dan Derivat Metadon
Fenilpiperidin

Morfin dan Alkaloid opium Propoksifen

Propoksifen Antrain-Interbat
Analgetika Non Narkotik
Analgetika non-narkotik bersifat tidak adiktif dan kurang kuat
dibandingkan dengan analgetika narkotik. Obat-obat ini juga dinamakan
analgetika perifer, tidak menurunkan kesadaran dan tidak mengakibatkan
ketagihan secara kimiawi. Obat-obatan ini digunakan untuk mengobati
nyeri yang ringan sampai sedang dan dapat dibeli bebas. Obat-obatan ini
efektif untuk nyeri perifer pada sakit kepala, dismenore (nyeri
menstruasi), nyeri pada inflamasi, nyeri otot, dan arthritis ringan sampai
sedang. Kebanyakan dari analgetika menurunkan suhu tubuh yang
tinggi,sehingga mempunyai efek antipiretik. Beberapa analgetika seperti
aspirin, mempunyai efek antiinflamasi dan juga efek antikoagulan. Efek
samping dari analgetika yang paling umum adalah gangguan lambung,
kerusakan darah, kerusakan hati, dan juga reaksi alergi di kulit.
 Infographic Style
Parasetamol
Paracetamol bekerja mengurangi produksi
prostaglandin yang terlibat dalam proses nyeri
dan edema dengan menghambat enzim
cyclooxygenase (COX).

Asam mefenamat (golongan antranilat) Ibuprofen

Asam mefenamat merupakan kelompok
antiinflamasi non steroid bekerja dengan Ibuprofen merupakan derivat asam
cara menghambat sintesa prostaglandin propionat yang diperkenalkan banyak
dalam jaringan tubuh dengan menghambat negara. Obat ini bersifat analgesik dengan
enzim siklooksiginase sehingga mempunyai daya antiinflamasi yang tidak terlalu kuat.
efek analgesik, antiinflamasi dan antipiretik Menghambat sintesis prostaglandin dgn
menghambat COX-1 & C
 obat analgesik non narkotik
Asam mefenamat Metadon
(golongan antranilat)

Parasetamol Propoksifen

Ibuprofen Antrain-Interbat
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