REFERAT

SUBSTANSI P
Pembimbing:
dr. Ihyan Amri., Sp.B

Penyusun:
Adisty Dwi Wulandari 201704200185
Afdini Safitri Dwi M.S 201704200186
BAB 1
 Stimulus
LATAR BELAKANG

Serabut saraf
• Pre-Sinaptik
Nyeri • Sinaptik : Substansi P
• Post Sinaptik

Otak
• Cornu
Dorsalis
BAB 2
TINJAUAN PUSTAKA
 Substansi P
Substansi P merupakan neuropeptida yang bekerja untuk
mengatur nyeri di Hipotalamus, struktur limbic, otak tengah,
batang otak, thalamus, basal ganglia dan medulla spinalis.
(Howard et all, 2007).

Substansi P menurut Lembeck adalah sensor saraf yang terkait

dengan transmisi rasa sakit yang terletak diakar dorsal
sumsum tulang belakang. Ekspresi substansi p terbatas pada
sistem saraf pusat (CNS) dan sistem saraf tepi (PNS) (Harrison
S, et all, 2001).
 Gambar 2. 2 Representasi
skematis dari biosintesis Substansi
P (Harrison S, et all, 2001)
 01 03
Peran Substansi P Penyampaian pesan dari
dalam persepsi neuron sensoris ke Kornu
dan transmisi dorsalis
PERAN SUBSTANSI P

nyeri dan
inflamasi

02 04
Sinyal nyeri melalui Penyampaian pesan
Primary Sensory nyeri dari Jalur
Afferents (First- NeuronalS
Order Neurons)

(Howard et al, 2007).

 NYERI

BERDASARKAN BERDASARKAN BERDASARKAN

DURASI ETIOLOGI LOKASI

• NYERI AKUT • NOSISEPTIF • Nyeri

• NYERI • NEUROPATIK superficial
KRONIS • Nyeri viseral
• Nyeri alih
(referred pain)
• Nyeri radiasi
 Antara stimulus cedera
jaringan dan pengalaman subjektif
nyeri terdapat empat proses
MEKANISME NYERI

tersendiri : tranduksi, transmisi,

modulasi, dan persepsi (Mochamad
Bahrudin, 2017).
berperan dalam penghantaran impuls nyeri
Neuro tansmitter dan neuroregulator yang Neurotransmitter Neuromodulator

Substansi P (Peptida) Endorfin (morfin endogen)

•Ditemukan pada neuron nyeri di kornu
dorsalis (peptide eksitator) berfungsi
untuk mentransmisi impuls nyeri dari
perifer ke otak dan dapat
menyebabkan vasodilatasi dan
edema.
• Merupakan substansi sejenis morfin
yang disuplai oleh tubuh. Diaktivasi
oleh daya stress dan nyeri.
Terdapat pada otak, spinal, dan
traktus gastrointestinal. Berfungsi
memberi efek analgesic

Serotonin
• Dilepaskan oleh batang otak Bradikinin
dan kornu dorsalis untuk • Dilepaskan dari plasma dan
menghambat transmisi nyeri. pecah disekitar pembuluh darah
pada daerah yang mengalami
cedera. Bekerja pada reseptor
saraf perifer, menyebabkan
Prostaglandin peningkatan stimulus
nyeri.Bekerja pada sel,
• Dibangkitkan dari pemecahan menyebabkan reaksi berantai
pospolipid di membran sel sehingga terjadi pelepasan
dipercaya dapat meningkatkan prostaglandin
sensitivitas terhadap sel.
Bab 3
Kesimpulan
 Substansi P
CONCLUSIONS
menurut Lembeck adalah sensor
saraf yang terkait dengan transmisi
rasa sakit yang terletak diakar
dorsal sumsum tulang belakang.
Ekspresi substansi p terbatas pada
sistem saraf pusat (CNS) dan
sistem saraf tepi (PNS)
Neurotrasnmitter
ditemukan pada neuron nyeri di kornu
dorsalis (peptide eksitator) berfungsi
untuk mentransmisi impuls nyeri dari
perifer ke otak dan dapat menyebabkan
vasodilatasi dan edema
 Pelepasan Substansi P

Selama peradangan, pelepasan SP meningkat dan pengikatan reseptor NK1

CONCLUSIONS

diperpanjang melampaui lamina I dan III ke lapisan lamina IV dan VI yang

lebih dalam. Pelepasan SP ini menghasilkan rekrutmen dan aktivasi neuron
tingkat kedua yang berkepanjangan. Ini adalah tindakan SP yang
bertanggung jawab untuk allodynia dan hyperalgesia. Depolarisasi neuron
tingkat kedua diperpanjang sebagai respons terhadap rangsangan berbahaya
intensitas rendah (hiperalgesia) atau rangsangan termal dan mekanik
(allodynia), menghasilkan persepsi nyeri hebat (nyeri kronis) karena jalur
neuron menjadi hipersensitif. Studi internalisasi reseptor NK1 telah
mendukung peran SP dalam hiperalgesia / allodynia. SP berperan dalam
memodulasi respons terhadap nyeri hebat kronis dan dalam menambah
keadaan nyeri persisten
TERIMA
KASIH
 01 02
Theory Theory
Neptune is the farthest planet in our Solar Venus has a beautiful name and is the second
LITERATURE REVIEW

System. It’s the fourth-largest by diameter planet from the Sun. It’s terribly hot, even
and the densest hotter than Mercury

03
Theory
Mercury is the closest planet to the Sun and
the smallest one in the Solar System—it’s
only a bit larger than our Moon
04
Theory
Despite being red, Mars is a cold place, not
hot. It’s full of iron oxide dust, which gives
the planet its reddish cast
 26 27 28 29 30 31 1
WEEK 1

2 3 4 5 6 7 8
WEEK 2
SCHEDULE

9 10 11 12 13 14 15
WEEK 3

16 17 18 19 20 21 22
WEEK 4

23 24 25 26 27 28 29
WEEK 5
 JUPITER
Jupiter is the biggest planet in our Solar System and
also the fourth-brightest object in the sky
METHODOLOGY

VENUS SATURN
Venus has a beautiful name and is the Saturn is a gas giant, composed mostly of
second planet from the Sun. It’s terribly hot hydrogen and helium
 TEST 1 TEST 2 TEST 3 TEST 4 TEST 5

Describe here your metrics 1

TEST

Describe here your metrics 2

Describe here your metrics 3

Describe here your metrics 4

 30,000 2,000
Sample size Cases that need further research
RESULTS ANALYSIS

If you want to modify this graph, click on it, follow the link, If you want to modify this graph, click on it, follow the link,
change the data and replace it change the data and replace it
 1,520
Saturn is a gas giant, composed
RESULTS ANALYSIS

mostly of hydrogen and helium

5,000
Jupiter is the biggest planet in
our Solar System

3,250
Neptune is the farthest planet
from the Sun
 03
CONCLUSION
CONCLUSIONS

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BIBLIOGRAPHY

AUTHOR Year Title of the publication. Publisher

AUTHOR Year Title of the publication. Publisher

AUTHOR Year Title of the publication. Publisher

AUTHOR Year Title of the publication. Publisher

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