Demam Tifoid

Kel 3:
Luluk Hasanah
Nidya Rahma Kumala
Sarah Aulia
Susi Pramawati
 Demam Tifoid ?

Demam tifoid atau tipes adalah infeksi bakteri

yang dapat mengganggu banyak organ
terutama saluran pencernaan. Tanpa
pengobatan yang tepat, tifoid dapat
menyebabkan komplikasi serius dan menjadi
fatal. Penyakit ini disebabkan oleh bakteri
Salmonella typhi yang seringkali menyebabkan
keracunan makanan. Orang yang terinfeksi
dapat menyebarkan bakteri melalui kotoran
atau urin. Jika seseorang makan atau minum
yang telah terkontaminasi, maka orang tersebut
dapat terkena demam tifoid.
Place Your Picture Here

Salmonella Typhi
Salmonella typhi (S. typhi) merupakan kuman patogen
penyebab demam tifoid. S. typhi merupakan bakteri gram
negatif, yang tidak memiliki spora,bergerak dengan flagel
peritrik, bersifat intraseluler fakultatif dan anerob
fakultatif15'. Ukurannya berkisar antara 0,7- 1,5X 25 pm,
memiliki antigen somatik (O), antigen flagel (H) dengan 2 fase
dan antigen kapsul (Vi).

S. typhi mampu bertahan hidup selama beberapa bulan

sampai setahun jika melekat dalam, tinja, mentega, susu, keju
dan air beku.
P
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Your Picture Here And Send To Back Your Picture Here And Send To Back

basil yang sudah memasuki tubuh

PATOGENESIS Salmonella
manusia, akan melewati lambung
mencapai ususthypi
halus dan invasi
ke jaringan limfoid (plak peyer)
yang merupakan tempat untuk
berkembang biak. Melalui saluran
limfa kuman masuk aliran darah
sistemik (bakterimia I) dan
mencapai sel-sel retikulo
endothelial dari hati dan limfa.
Fase ini dianggap masa inkubasi
(7-14 hari). Kemudia dari
jaringan ini kuman dilepas ke
sirkulasi sistemik (bakterimia II)
melalui ductus torasikus dan
 Penularan akan penyakit tipes biasanya disebut dengan
metode 5 F
FOOD
Makanan yang di konsumsi dan di dapati dari tempat yang
kurang bersih bisa menjadi media penularan penyakit tipes
terlebih lagi makanan bisa terkontaminiasi akibat dari
pengolahan makanan yang tidak benar seperti tidak di cuci dll

FINGERS FOMITUS DAN FECES

Jari-jari pada tangan bisa juga
menjadi media penularan penyakit
tipes, penularan lewat jari tangan
dan tangan sangat beresiko utama
nya jika tidak mencuci tangan
setelah BAK atau BAB .
FLY / Lalat
Lalat suka sekali hinggap di tempat kotor
dan benda kotor di mana tempat dan hal
seperti ini menjadi sarang bagi bakteri
penyebab penyakit tipes ,lalat yang
hinggap di tempat kotor dan benda dapat
membawa bakteri penyebab penyakit tipes
di kaki nya yang kemudian hinggap di
makanan dan pada akhirnya menimbulkan
kontaminasi penyakit tipes .
Seseorang yang sudah terinfeksi
bakteri penyebab tipes, muntahan
akibat dari gejala tipes yang di
deritanya bisa menjadi media lain
untuk menularkan penyakit tipes dan
juga Kotoran/Feces yang dibuang
oleh penderita tipes banyak memiliki
bakteri penyebab tipes.
Gejala Klinis

Nyeri kepala Demam Gangguan Pencernaan

(frontal/dahi), nyeri biasanya bersifat intermiten
otot, mialgia, insomnia terutama di sore dan malam
hari
• Lidah putih(coated tongue)
• Nyeri perut
• Diare
• Perut kembung
• Mual dan muntah
• Sulit BAB
Komplikasi berat pada demam tifoid:
Tifoid toksik (tifoid ensefalopati)

Syok septik

Pendarahan dan perorasi intestinal

Peritonitis

Hepatitis tifosa

Pankreatitis tifosa

Pneumonia

Dan komplikasi lain

Tata Laksana
Demam Tifoid
Progress steps
Tirah Baring Diet Terapi Simtomatik Terapi Kausal Vitamin

Untuk mencegah pasien Diet tinggi kalori tinggi  Antipiretik= jika pasien Terapi kausal dengan Pemberian vitamin
demam kita berikan
bisa jadi perforasi protein, namun rendah antipirietik contoh pilihan pemberian antibiotik lini kepada pasien sebagai
karena infeksi usus serat diharapkan agar adalah paracetamol sesuai pertama maupun lini suplemen.
usus tidak bekerja dosis, atau diberikan infus kedua sesuai kondisi
apabila demamnya terlalu
terlalu berat. tinggi. dan kebutuhan pasien.
 Antimietik= jika pasien
mengeluhkan mual atau
muntah maka diberikan
antimietik contoh pilihan
adalah domperidone oral,
apabila muntah terlalu berat
maka harus rawat inap dan
diinjeksikan ondansetron atau
metoclopramide.
Kebijakan dasar pemberian
antimikroba
Antimikroba dapat segera diberikan
bila diagnosis klinis telah dilakukan

Sebelum antimikroba diberikan, harus

diambil specimen darah.

Antikmikroba yang dipilih harus

mempertimbangankan:
 sensitive dan potensial untuk tifoid
 mempunyai sifat farmakologi dan afinitas Yourtinggi sehingga
Text Here
tepat menuju organ
You cansasaran
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 berspektrum sempit
 pemberian yang mudah dan dapat ditoleransi oleh pasien
anak dan wanita hamil
Strategi Pemberian
Antibiotik
Contents A Antimikroba segera diberikan
bila diagnosis telah dibuat
Antimikroba yang diberikan
Contents B sebagai terapi awal dengan
golongan lini perrama untuk
tifoid. Antikmiktoba lini
pertama adalah kloramfenikol,
amoxicillin, trimetroprim-
sulfametoksazol. Bila tidak
Contents C
efektif dapatdengan
Bila pasien digantiklinis
denganberat
antimikroba
sampat toksis,lini kedua,
atau syokseperti
berat.
seftriakson,
Antimikrobacefixim,
yang efektif
quinolone.
adalah pemberian secara
Strategi Pemberian
Antibiotik
Contents D Bila pasien dengan riwayat
pernah mengalami tifoid,
maka pengobatan pertama
adalah golongan quinolone
Contents E Jangan memilih antimikroba
yang dikenal tidak potensial
untuk tifoid
Contents F
Untuk pemberian antimikroba
harus mempertimbangkan
tentang efikasi, tingkat
kepekaaan, harga dan efek
samping yang ditimbulkan.
Pilihan antimikroba untuk demam
tifoid
Thanks You
Any Question?
Gejala Klinis
01 Demam
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03 Gangguan Saluran Pencernaan

Lidah putih, nyeri perut, diare, perut kembung, sulit BAB

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