Tabel Data Farmakokinetika P2

Jam
ke0,5
1
2
3
4
6
8
10
11
23

Area

Cp

1021286
1354882
1266709
1160808
1144702
785455
688147
516513
421465
105544

28,5966909
37,8987519
35,4401174
32,4871517
32,0380486
22,0207297
19,3073729
14,5214944
11,871156
3,0619484

Log Cp

Ln Cp

1,456315781
1,578624908
1,549495152
1,511711636
1,505666055
1,342831706
1,285723186
1,162011312
1,074493012
0,485997867

B (-K)

3,35329101
3,63491818
3,56784444
3,48084468
3,46692421
3,09198427
2,96048704 0,120196
2,67562992
2,47411159
1,11905144

A (Ln
B)

3,8698

LR I (eliminasi)
Ln B = a
B
24.739 (-K)
K

C'

Cr

Ln Cr

3,8097 45,1368958 16,540205 2,80579408

3,7496 42,504077 4,6053251 1,52721326
3,6294 37,6901957 2,2500783 0,81096502

Persamaan kurva baku untuk menghitung Cp adalah y = 35862,59x - 4265,40

Ln Cp = Ln B - k.t
y = 3.8698 - 0,1202x
a = 3.8698
b = -0,1202
r = -0.9979

Ln C'

38.698
47,933
-0,1201959
0,1201959

B (-Ka)

A (Ln
A)

1,242223 3,1639

LR II (absorbsi)
Ln Cp = Ln A - k.t
y = 3,1639 - 1,2422x
a = 3,1639
b = -1,2422
r = 0,9388
AUC 0-t
AUC 0-inf
Half Life

Ln A = a
A
Ka
(-Ka)

3,1639
23,6627007
1,2422235
-1,2422235

351,5302
377,0049
5,766812

Grafik Cp vs t
40
35

Cp (g/ml)

30
25

LR I

20
15
10

y = -1.5659x + 34.451
R = 0.8524

Linear (LR I)
Linear (LR II)

5
0
5
10
15
-5 0
y = -1.2422x + 3.1639
t (jam)
R = 0.8815

LR II

20

25