Referat

Osteogenesis Imperfecta

Oleh
dr. Andrian Sitompul
NIM. 1750913310001

Pembimbing :

dr. Essy Dwi Damayanthi, Sp.OT

DEPARTEMEN ILMU BEDAH

FAKULTAS KEDOKTERAN UNIVERSITAS LAMBUNG MANGKURAT
RSUD ULIN BANJARMASIN
Oktober, 2018
 DAFTAR ISI

Daftar Isi ……………………………………………………………….. ii

Daftar Tabel …………………………………………………………… iii
Daftar Gambar ………………………………………………………… iv
BAB I Pendahuluan …………………………………………………. 1
BAB II Tinjauan Pustaka ……………………………………………. 2
 Definisi ………………………………………………………... 3
 Etiologi ………………………………………………………... 3
 Epidemiologi .............................................................................. 4
 Patogenesis ................................................................................. 4
 Manifestasi Klinis ..................................................................... 6
 Pemeriksaan Penunjang .......................................................... 10
 Diagnosis................................................................................... 12
 Komplikasi ............................................................................... 12
 Penatalaksanaan ……………………………………………... 14
o Medikamentosa...………………………………………. 14
o Pembedahan Orthopaedi............................................... 18
o Modifikasi Gaya Hidup ……………………………….. 19
 Prognosis................................................................................... 19
BAB III Penutup. ….………………………………………………….. 20
Daftar Pustaka …………………………………………………………. 22
 DAFTAR TABEL

Tabel Halaman

1 Nomenklatur Osteogenesis Imperfecta 6

2 Severity Grading Scale of Osteogenesis Imperfecta......................... 7

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 DAFTAR GAMBAR

Gambar Halaman

1 Lokasi Gen COL1α1 dan Gen COL1α2 3

2 Struktur Molekul Kolagen 4

3 Bayi Osteogenesis Imperfecta tipe III 9

4 Wormian Bone 11

5 Radiografi Toraks 11

6 Sklera Biru Pada Osteogenesis Imperfecta....................................... 13

7 Dentinogenesis Imperfecta....... ....................................................... 14

8 Bone Remodeling Target Terapi ..................................................... 15

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